Oklahoma COBRE in Structural Biology

俄克拉荷马州 COBRE 结构生物学

• 批准号: 10631144
• 负责人: ANN H WEST
• 金额: $ 114.15万
• 依托单位: UNIVERSITY OF OKLAHOMA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631144
• 关键词: Address; Area; Award; Biological Sciences; Centers of Research Excellence; Client; Communities; Consultations; Core Facility; Cryoelectron Microscopy; Crystallization; Data Collection; Development; Education; Educational workshop; Faculty; Fees; Freezing; Funding; Goals; Grant; Group Meetings; Health Sciences; Institution; Interdisciplinary Study; Location; Mentors; Mission; Molecular Structure; Oklahoma; Paper; Peer Review; Phase; Pilot Projects; Postdoctoral Fellow; Preparation; Production; Proteins; Publishing; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Roentgen Rays; Sampling; Series; Services; Structure; Students; Training; Training and Education; Universities; Visit; base; biophysical analysis; biophysical properties; career; experience; faculty support; human disease; insight; instrumentation; macromolecule; mid-career faculty; novel therapeutic intervention; outreach; posters; programs; protein expression; protein purification; structural biology; symposium

Project Summary (Overall Center) Structural biology is a multidisciplinary research area that focuses on the important relationship between macromolecular structure and function. The Oklahoma Center of Biomedical Research Excellence (COBRE) in Structural Biology (OCSB) was established in 2012 with Phase 1 funding. The OCSB supports faculty research projects and two research core facilities on the OU-Norman and OU Health Sciences Center campuses for crystallization of macromolecules of biomedical importance, X-ray data collection, protein expression and purification and biophysical analysis. The overall objective of this Phase 3 application is to provide essential research support in the State of Oklahoma and the region in the form of shared core facilities, training and expertise in structural biology, and an open competitive pilot project program. The specific aims of this Phase 3 application are to: 1) Sustain and enhance the research cores established and developed in Phases 1 and 2 and facilitate their transition to self-sustaining cores and 2) Increase the critical mass of investigators in the field of structural biology in the State of Oklahoma by supporting researchers through a competitive pilot project program.

项目概要（整体中心） 结构生物学是一个多学科研究领域，重点关注结构生物学之间的重要关系 大分子结构和功能。俄克拉荷马州生物医学卓越研究中心 (COBRE) 结构生物学 (OCSB) 成立于 2012 年，获得第一阶段资金。 OCSB 支持教师研究 OU-诺曼和 OU 健康科学中心校园的项目和两个研究核心设施 具有生物医学重要性的大分子结晶、X 射线数据收集、蛋白质表达和 纯化和生物物理分析。第三阶段应用的总体目标是提供必要的 俄克拉荷马州和该地区的研究支持以共享核心设施、培训和 结构生物学方面的专业知识，以及开放的竞争性试点项目计划。第三阶段的具体目标 申请的目的是： 1) 维持和加强在第一阶段和第二阶段建立和开发的研究核心 促进其向自我维持核心的过渡；2) 增加该领域研究人员的临界数量 俄克拉荷马州的结构生物学通过竞争性试点项目支持研究人员 程序。

项目成果

Friend or Foe: Protein Inhibitors of DNA Gyrase.

朋友还是敌人：DNA 旋转酶的蛋白质抑制剂。

• 发表时间: 2024-01-29
• 影响因子: 4.2
• 作者: Ruan, Shengfeng;Tu, Chih;Bourne, Christina R
• 通讯作者: Bourne, Christina R

Machine learning based implicit solvent model for aqueous-solution alanine dipeptide molecular dynamics simulations.

基于机器学习的隐式溶剂模型，用于水溶液丙氨酸二肽分子动力学模拟。

• 发表时间: 2023-01-31
• 影响因子: 3.9
• 作者: Yao, Songyuan;Van, Richard;Pan, Xiaoliang;Park, Ji Hwan;Mao, Yuezhi;Pu, Jingzhi;Mei, Ye;Shao, Yihan
• 通讯作者: Shao, Yihan

Free Energy Profile Decomposition Analysis for QM/MM Simulations of Enzymatic Reactions.

用于酶反应 QM/MM 模拟的自由能分布分解分析。

• 发表时间: 2023-11-28
• 作者: Pan, Xiaoliang;Van, Richard;Pu, Jingzhi;Nam, Kwangho;Mao, Yuezhi;Shao, Yihan
• 通讯作者: Shao, Yihan

Controllable membrane damage by tunable peptide aggregation with albumin.

通过可调节肽与白蛋白的聚集来控制膜损伤。

• 发表时间: 2022-12
• 作者: Hamsici, Seren;Gunay, Gokhan;Acar, Handan
• 通讯作者: Acar, Handan

Training machine learning potentials for reactive systems: A Colab tutorial on basic models.

训练反应系统的机器学习潜力：关于基本模型的 Colab 教程。

• 发表时间: 2024-04-15
• 影响因子: 3
• 作者: Pan, Xiaoliang;Snyder, Ryan;Wang, Jia;Lander, Chance;Wickizer, Carly;Van, Richard;Chesney, Andrew;Xue, Yuanfei;Mao, Yuezhi;Mei, Ye;Pu, Jingzhi;Shao, Yihan
• 通讯作者: Shao, Yihan