256-channel Digital Neural Signal Processor Real-Time Data Acquisition System

256通道数字神经信号处理器实时数据采集系统

• 批准号: 10630883
• 负责人: SYDNEY S CASH
• 金额: $ 55.45万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630883
• 关键词: Acceleration; Anesthesia procedures; Animal Model; Area; Brain; Cells; Cerebrum; Clinical; Cognition; Complex; Data; Devices; Electrodes; Equipment; Functional disorder; Human; Infiltration; Laboratories; Language; Microelectrodes; Neurologic; Neurosciences; Operative Surgical Procedures; Productivity; Research Project Grants; Seizures; Sleep; System; Technical Expertise; Time; Work; brain cell; brain research; cost; data acquisition; digital; materials science; member; neurophysiology; neuropsychiatry; neuroregulation; neurotransmission; next generation; novel therapeutics; tumor

Project Summary/Abstract: Understanding the human brain’s astounding functions and profoundly disabling dysfunctions, from the level of the single cell to the span of the entire cerebrum, is the primary focus of 21st-century neuroscience. Historically, revealing the complex mechanisms underlying the function, and dysfunction, of the brain has relied primarily on non-human animal models. Advances in materials science, computational analytics, surgical approaches, and neurophysiology now enable recordings from hundreds to thousands of contacts in the human brain for research purposes. Furthermore, in the last 15 years, specialized microelectrode recording systems to record from the human brain as well as modulate its activity have been increasingly used in clinical settings. Unfortunately, the equipment to acquire and faithfully record this rare and precious data is costly and requires considerable technical expertise to maintain and operate. These hurdles can be mitigated by the fact that multiple laboratories can share such equipment to pursue highly significant essential neuroscientific questions in parallel. Team members on this application have used human intracranial recordings to make discoveries in many areas of neuroscience. Leaders in the field of human neurophysiology, the groups represented by this extensive list of studies have worked collaboratively for years as well as carried out independent parallel studies on human brain function. However, current systems used by these groups are becoming obsolete and lack the capability of recording from the latest high-count electrodes. These devices and the next generation recording system represents the next step in answering key human neuroscientific questions regarding cognition, language, anesthesia, sleep, seizure activity, neuromodulation, and tumor infiltration. Acquiring the latest, cutting-edge recording and stimulation system for high channel count intracranial recordings capable of single brain cell human recordings will allow a local consortium of highly productive human neuroscientific users to expand the reach of this group’s basic and translational scientific efforts. This team approach, centered on extraordinary human neurophysiological recording equipment that is shared across multiple research projects, is critical for accelerating novel therapies for a wide range of neurological and neuropsychiatric challenges.

项目摘要/摘要： 从以下层面了解人类大脑的惊人功能和严重的功能障碍 从单个细胞到整个大脑，是 21 世纪神经科学的主要焦点。 揭示大脑功能和功能障碍背后的复杂机制主要依赖于 非人类动物模型的进展。 神经生理学现在可以记录人脑中数百到数千个接触 进一步的研究目的，在过去的15年里，专门的微电极记录系统来记录 来自人脑的信号以及调节其活动已越来越多地用于临床环境。 不幸的是，获取并忠实记录这些稀有而珍贵的数据的设备成本高昂，并且需要 维护和操作所需的大量技术专业知识可以通过以下事实来缓解。 多个实验室可以共享此类设备来研究非常重要的基本神经科学问题 并联。 该应用程序的团队成员使用人类颅内记录在许多方面取得了发现 人类神经生理学领域的领导者，以此为代表的团体。 广泛的研究清单已合作多年，并进行了独立的平行研究 然而，这些团体当前使用的系统正在变得过时并且 这些设备和下一代设备缺乏记录功能。 记录系统代表着回答人类神经科学关键问题的下一步 认知、语言、麻醉、睡眠、癫痫活动、神经调节和肿瘤浸润。 最新、最先进的记录和刺激系统，用于高通道数颅内记录，能够 单脑细胞人类记录将允许一个高生产力的人类神经科学的本地联盟 用户扩大该小组的基础和转化科学努力的范围， 以非凡的人类神经生理学记录设备为中心，该设备在多个 研究项目对于加速各种神经系统和疾病的新疗法至关重要 神经精神挑战。