COBRE Center for Central Nervous System Function

COBRE 中枢神经系统功能中心

基本信息

批准号：
10630553
负责人：
JEROME N SANES
金额：
$ 119.63万
依托单位：
BROWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2028-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10630553
关键词：
Applications Grants Award Behavior Biological Models Biology Brain Brain Diseases Centers of Research Excellence Central Nervous System Communities Computational Biology Core Facility Country Data Analyses Disease model Ensure Environment Experimental Designs Faculty Functional Magnetic Resonance Imaging Funding Generations Goals Grant Growth High Performance Computing Hospitals Human Human Characteristics Hybrids Japan Journals K-Series Research Career Programs Leadership Link Magnetic Resonance Imaging Mentors Mission National Institute of General Medical Sciences Nervous System Physiology Neurons Neurosciences Neurosciences Research Outcome Paper Peer Review Performance Phase Phase Transition Pilot Projects Positioning Attribute Pre-Clinical Model Privatization Publications Publishing Records Research Research Infrastructure Research Institute Research Methodology Research Personnel Research Project Grants Research Support Research Technics Resources Rhode Island Rodent Science Scientist Services System United States United States Department of Veterans Affairs United States National Institutes of Health Universities Vision Work Writing behavioral phenotyping brain health career cluster computing cognitive enhancement cohort design member neuroimaging novel outreach services programs research facility success

项目摘要

The long-term goal of the COBRE Center for Central Nervous System Function is to develop a neuroscience research center that provides research support to a wide array of neuroscience researchers at Brown University and its affiliated hospitals and the Rhode Island neuroscience research community. Since we began our COBRE in 2013, we have supported 13 Project Leaders and nine Pilot Project Leaders as they developed their research and academic careers. Collectively, our supported cohort has been awarded nearly 20 R01 or equivalent research grants, which along with other awarded grants has yielded more than $50 million in external funding. Grants relevant to our COBRE received by members of our Research Cores have totaled another $4 million. Of the 11 Project Leaders who served two or more years, nine have successfully graduated, with a tenth having received positive reviews of an R01 grant proposal. Collectively, our COBRE supported scientists have published nearly 130 peer-reviewed papers citing COBRE support and more than 400 papers overall. These papers have appeared in prestigious journals, including Nature Human Behavior, Current Biology, Neuron, eLife, PLoS Computational Biology, Journal of Neuroscience and other field-specific journals. We have developed a research core to assist our community in best practices for experimental design and data analysis. The main objective for Phase 3 COBRE support relates to building-out our research core to serve the needs of the neuroscience community at Brown and Rhode Island and also to expand and strengthen our Pilot Project Program. We will enhance the scope of our Research Core by integrating two existing neuroscience core facilities, the MRI Research Facility and the Rodent Behavior Phenotyping Core, into one administrative entity. Additionally, we will partner with service cores of other local COBREs and those at Brown-affiliated hospitals to broaden our service outreach. Our vision is that by sustaining and transitioning the established research infrastructure into an integrated entity, we will enable neuroscientists to conduct their work more effectively and efficiently.

COBRE 中枢神经系统功能中心的长期目标是发展神经科学研究中心为布朗大学的众多神经科学研究人员提供研究支持大学及其附属医院和罗德岛州神经科学研究界。自从我们开始在 2013 年的 COBRE 中，我们支持了 13 名项目负责人和 9 名试点项目负责人的发展他们的研究和学术生涯。总的来说，我们支持的团队已获得近 20 个 R01 或同等研究补助金，连同其他授予的补助金已产生超过 5000 万美元外部资金。我们的研究核心成员收到的与 COBRE 相关的拨款总计另外400万美元。在任职两年或以上的 11 名项目负责人中，有 9 名已顺利毕业，其中十分之一收到了 R01 拨款提案的积极评价。总的来说，我们的 COBRE 支持科学家发表了近 130 篇引用 COBRE 支持的同行评审论文，以及 400 多篇论文全面的。这些论文发表在《Nature Human Behaviour》、《Current》等著名期刊上 Biology、Neuron、eLife、PLoS Computational Biology、Journal of Neuroscience 和其他特定领域期刊。我们开发了一个研究核心来协助我们的社区进行实验设计和实施的最佳实践数据分析。第三阶段 COBRE 支持的主要目标涉及建立我们的研究核心满足布朗和罗德岛神经科学界的需求，并扩大和扩展加强我们的试点项目计划。我们将通过整合两个领域来扩大我们的研究核心范围现有的神经科学核心设施、MRI 研究设施和啮齿动物行为表型核心，合并为一个行政实体。此外，我们将与其他本地 COBRE 的服务核心以及那些在布朗附属医院扩大我们的服务范围。我们的愿景是通过维持和转型将已建立的研究基础设施整合为一个综合实体，我们将使神经科学家能够开展他们的研究工作更加有效和高效。