Comprehensive Research Experiences to Advance Training and Education (CREATE) for Future Cancer Researchers

全面的研究经验可促进未来癌症研究人员的培训和教育 (CREATE)

基本信息

批准号：
10664861
负责人：
Priyamvada Rai
金额：
$ 27.37万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10664861
关键词：
Academic Training Academic skills Address Affect Area Bioinformatics Biological Markers Biology Biomedical Research Biotechnology Cancer Burden Cancer Control Cancer Research Project Catchment Area Cause of Death Clinical Oncology Clinical Trials Design Communities Community Health Community Outreach Complement Comprehensive Cancer Center Country Coupled Data Analyses Data Set Databases Development Diagnosis Disease Education Educational Curriculum Educational workshop Ensure Environment Epigenetic Process Exposure to Faculty Feedback Fellowship Program Florida Future Genome Goals Health Disparities Research Immunotherapy Incidence Incubators Individual Infrastructure Institution Instruction Knowledge Literature Location Malignant Neoplasms Mentors Methodology Mining Modernization Monitor Oncologist Oncology Outcome Participant Patients Physicians Population Positioning Attribute Public Health Qualifying Reading Research Research Institute Research Personnel Research Project Grants Resources Students Therapeutic Training Training and Education Treatment outcome Tumor Biology United States Universities Validation Writing anticancer research burden of illness cancer health disparity career career development commercialization drug development drug discovery efficacy evaluation epigenome experience faculty mentor faculty research field trip hands on instruction innovation insight interest medical schools next generation novel outreach peer peer coaching peer networks personalized medicine phase I trial programs recruit screening skills sociodemographics socioeconomic disparity summer program symposium technological innovation therapeutic target tool trial design undergraduate research undergraduate research experience undergraduate student

项目摘要

Project Summary Despite major advances in diagnosis and treatment, there remains a need for sustained research and therapeutic innovation to reduce cancer burden. Besides experimental biology, the landscape of oncology research now encompasses computational patient dataset mining for new biomarkers and therapeutic targets, genome and epigenome analysis-based personalized medicine, and application of how sociodemographic and socioeconomic disparities affect cancer incidence and outcomes. The next generation of researchers must receive early exposure to this comprehensive, integrated view of modern oncology, so they can make informed and innovative decisions regarding specialization or cross-specialization options throughout their future education. The proposed CREATE program for future cancer researchers aims to accomplish this goal by integrating a 10-week mentored undergraduate cancer research program with foundational modules on computational drug discovery and development and cancer health disparities-based research. This program will build and expand on the UMMSOM/Sylvester Comprehensive Cancer Center (SCCC)-sponsored pre-existing summer program infrastructure to facilitate research projects tailored to individual scholar interest alongside comprehensive academic and career development support. Complementarily, through a hands-on mini-project, CREATE scholars will receive hands-on instruction in bioinformatics and computational approaches required to develop a robust therapeutic pipeline. SCCC serves a diverse catchment area that will be leveraged to provide CREATE scholars with unique opportunities for understanding the impact of cancer disparities at the community level on disease incidence and treatment outcomes. Currently, only undergraduates actively engaged in computational projects or health disparities research benefit from their exposure to these essential research areas. Our proposed curriculum will ensure all our scholars develop a working understanding of these areas in addition to accomplishing substantive bench research with world-class faculty mentors. CREATE scholars will also experience clinical oncology components including physician shadowing and basic instruction in Phase I trial design. They will receive sustained programmatic and peer mentoring support as they navigate the next steps in their academic training. An important aspect of enhancing the cancer research workforce is outreach and engagement with student populations who do not have research opportunities due to their location or circumstances. SCCC is only the second NCI-designated center in the entire state of Florida. As such, our institutional summer program receives more qualified applicants than we can support, demonstrating a clear interest from undergraduates across the country in our cancer research resources and environment. We are, thus, in a unique position to offer the innovative CREATE program to help produce the next generation of cancer researchers with the comprehensive training and knowledge to succeed in oncology-based careers.

项目概要尽管诊断和治疗取得了重大进展，但仍然需要持续的研究和减少癌症负担的治疗创新。除了实验生物学之外，肿瘤学的前景现在的研究包括计算患者数据集挖掘新的生物标志物和治疗靶点，基于基因组和表观基因组分析的个性化医疗，以及社会人口统计学和社会经济差异影响癌症的发病率和结果。下一代研究人员必须尽早接触现代肿瘤学的这种全面、综合的观点，以便他们能够做出明智的决定以及关于未来专业化或跨专业化选择的创新决策教育。为未来癌症研究人员提出的 CREATE 计划旨在通过以下方式实现这一目标：将为期 10 周的指导本科生癌症研究计划与基础模块相结合计算药物发现和开发以及基于癌症健康差异的研究。该计划将建立并扩展 UMMSOM/西尔维斯特综合癌症中心 (SCCC) 资助的现有项目暑期项目基础设施，以促进根据个人学者兴趣量身定制的研究项目全面的学术和职业发展支持。作为补充，通过一个实践性的小项目， CREATE学者将接受生物信息学和计算方法方面的实践指导开发强大的治疗渠道。 SCCC 服务于多元化的集水区，将被利用来提供为学者创造独特的机会来了解癌症差异对社区的影响疾病发生率和治疗结果的水平。目前，只有本科生积极从事计算项目或健康差异研究受益于这些重要研究的接触地区。我们提出的课程将确保我们所有的学者对这些领域有一个有效的理解除了与世界一流的教师导师一起完成实质性的基础研究之外。创造学者将还体验临床肿瘤学组成部分，包括医生见习和第一阶段的基本指导试验设计。他们在下一步的发展过程中将获得持续的计划和同行指导支持他们的学术培训步骤。加强癌症研究队伍的一个重要方面是外展以及与由于地理位置或原因而没有研究机会的学生群体的接触情况。 SCCC 是整个佛罗里达州第二个 NCI 指定中心。因此，我们的机构暑期项目收到的合格申请者数量超出了我们的支持范围，这表明了一个明确的目标全国各地的本科生对我们的癌症研究资源和环境感兴趣。我们是，因此，我们处于独特的地位，可以提供创新的 CREATE 计划来帮助产生下一代癌症研究人员接受过全面的培训和知识，能够在肿瘤学领域的职业生涯中取得成功。