The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program

罗伯特·T·马利森耶鲁-朱拉隆功压力、酒精使用和精神病理学培训计划

• 批准号: 10665205
• 负责人: JOEL GELERNTER
• 金额: $ 24.69万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665205
• 关键词: Address; Affect; Alcohol consumption; Alcohols; Chronic; Clinical; Clinical Trials; Collaborations; Communities; Dedications; Developing Countries; Development; Disease; Drug Addiction; Economics; Environment; Faculty; Fellowship; Genetic; Genetic study; Goals; Health; Health Professional; Hospitals; Income; Infrastructure; Institution; Interdisciplinary Study; International; Lead; Medical Care Costs; Medicine; Mental disorders; Molecular Biology; Names; Policy Research; Population; Postdoctoral Fellow; Prevention; Psychiatry; Psychopathology; Psychopharmacology; Public Health; Recording of previous events; Research; Research Personnel; Research Training; Scientist; Site; Stress; Substance Use Disorder; Thailand; Training; Training Programs; Translational Research; Universities; clinical translation; community based participatory research; design; economic disparity; experience; implementation research; medical schools; multidisciplinary; neuroimaging; pre-doctoral; prevent; programs; social; stress related disorder

Abstract Psychiatric disorders are a set of chronic, non-communicable diseases (NCDs), a global public health problem of enormous economic, social, and medical cost to the international community. Stress, alcohol use and other factors (social and environmental; physical disorders) often exacerbate psychiatric disorders. Low and middle income and developing countries are disproportionately affected due to both economic disadvantages and the less well-established institutional infrastructures dedicated to the understanding, treatment and prevention of psychopathology. We propose a collaborative research training program in the multidisciplinary, translational research of stress, alcohol use and psychopathology between Faculty of Medicine, Chulalongkorn University in Bangkok, Thailand (the lead Thai site) Phramongkutklao (PMK) Hospital, also in Bangkok, and Prince of Songkla University (PSU) in Hat Yai, Thailand; and the Yale University School of Medicine in the U.S. The project is directed by leaders in Thailand and the US, Dr. Kalayasiri at Chulalongkorn, and Drs. Potenza and Gelernter at Yale, mPIs for this application. Three major training mechanisms are proposed for Thai trainees, including long- term (1-2-yr) predoctoral and postdoctoral fellowships, and short-term (1-6 month) fellowships. During the five- year program, training responsibility increases at Chulalongkorn, PMK, and PSU (as experience builds) and decreases at Yale. This program builds on an extensive research program in Psychiatry at Yale University School of Medicine, and on existing training and research collaborations between investigators at Yale and investigators at Chulalongkorn in the study of the genetics and clinical correlates of psychopathology (especially substance use disorders) in Thai populations. The program will contribute to the capacity of investigators at Chulalongkorn, PMK and PSU and more generally in Thailand to conduct state-of-the-art research in interdisciplinary and translational research in psychiatry through a range of training experiences (genetics, molecular biology, clinical, developmental, psychopharmacology, clinical trials, neuroimaging, implementation, community, and policy research); and has strong ongoing potential for clinical translation. The explicit long-term goal of the program will be to build a critical mass of scientists, health professionals, and academics with expertise and a sustainable research environment at the collaborating Thai institutions to better understand, treat, and prevent the NCDs of psychiatric illnesses. This training program is also specifically designed to serve a major public health purpose by enhancing Thailand’s capacity to confront major health concerns including alcohol and other stress-related disorders that are unprecedented in Thailand’s history. The context of this program is a long-term research and training collaboration between Yale and Chulalongkorn that focused on drug dependence which was co-led by at Yale by Drs. Gelernter and Malison. This new program with a new focus is expanded in scope to address the needs of Thailand better and include a Thai mPI, and is now named “The Robert T. Malison Yale-Chulalongkorn Stress, Alcohol Use and Psychopathology Training Program” for Dr. Malison, who passed in July, 2020.

抽象的 精神疾病是一组慢性非传染性疾病 (NCD)，是一个全球性公共卫生问题 压力、酗酒等给国际社会带来巨大的经济、社会和医疗成本。 因素（社会和环境；身体疾病）常常会加剧精神疾病。 收入和发展中国家由于经济劣势和 专门用于了解、治疗和预防疾病的机构基础设施不够完善 我们提出了一个多学科、转化性的合作研究培训计划。 朱拉隆功大学医学院之间的压力、酒精使用和精神病理学研究 泰国曼谷（泰国主要站点）同样位于曼谷的 Phramongkutklao (PMK) 医院和宋卡王子医院 泰国合艾大学（PSU）；和美国耶鲁大学医学院 该项目是 由泰国和美国领导人、朱拉隆功大学的 Kalayasiri 博士以及朱拉隆功大学的 Potenza 和 Gelernter 博士指导。 耶鲁大学为此应用提出了三种主要的培训机制，包括长期培训机制。 短期（1-2 年）博士前和博士后奖学金，以及短期（1-6 个月）奖学金。 年计划，朱拉隆功、PMK 和 PSU 的培训责任增加（随着经验的积累） 该项目建立在耶鲁大学精神病学广泛的研究项目的基础上。 医学部，以及耶鲁大学研究人员与研究人员之间现有的培训和研究合作 在朱拉隆功大学研究精神病理学（尤其是物质）的遗传学和临床相关性 该计划将有助于提高朱拉隆功调查人员的能力， PMK 和 PSU 以及更广泛的泰国在跨学科和 通过一系列培训经验（遗传学、分子生物学、临床、 发育、精神药理学、临床试验、神经影像学、实施、社区和政策 研究）；并且该项目具有强大的持续临床转化潜力。 建立足够数量的具有专业知识和可持续发展的科学家、卫生专业人员和学者 泰国合作机构的研究环境，以更好地了解、治疗和预防非传染性疾病 该培训计划也是专门为服务于重大公共卫生目的而设计的。 通过增强泰国应对主要健康问题（包括酒精和其他与压力相关的问题）的能力 该计划的背景是长期的研究和研究。 耶鲁大学和朱拉隆功大学之间的培训合作，重点关注药物依赖，由 在耶鲁大学，Gelernter 和 Malison 博士提出了这一新计划，其重点是扩大范围，以解决以下问题： 更好地满足泰国的需求，并包括泰国 mPI，现在被命名为“Robert T. Malison Yale-Chulalongkorn 2020 年 7 月去世的 Malison 博士的“压力、酒精使用和精神病理学培训计划”。