Genetics of Alcohol Dependence in African Americans: Recruitment

非裔美国人酒精依赖的遗传学：招募

• 批准号: 10474310
• 负责人: JOEL GELERNTER
• 金额: $ 37.64万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10474310
• 关键词: Acute; Address; Affect; African American; African American population; African ancestry; Alcohol Withdrawal Delirium; Alcohol dependence; Alcohol withdrawal syndrome; Chromosome Mapping; Clinical; Collection; Communities; Complex; Dangerousness; Data; Diagnosis; Ethics; Funding; Future; Genes; Genetic; Genomic Segment; Genotype; Heritability; Individual; Investigation; Medical; Outcome; Pennsylvania; Phenotype; Population; Recording of previous events; Reporting; Research Project Grants; Resources; Sampling; Sampling Studies; Societies; Substance Use Disorder; Time; United States; Universities; Variant; Work; alcohol effect; alcohol risk; base; comorbidity; cost; follow-up; genome wide association study; genome-wide; high risk sexual behavior; improved; psychiatric genomics; recruit; risk variant; trait

ABSTRACT Prevalent alcohol dependence (AD) in the United States, which has increased substantially over the past decade, is highly destructive and costly to individuals and to society. It is also moderately heritable. Delirium tremens (DTs) is a frequent, and often dangerous, consequence of acute alcohol withdrawal. We previously conducted an AD research project focused on the understudied African-American (AA) population and carried out numerous investigations including a pioneering genomewide association study (GWAS) of AD. We also reported GWAS of numerous related traits. Our findings included genomewide significant (GWS) risk loci associated to AD and related traits; our preliminary data support a risk locus for DTs at UNC13C (P= 9.4×10[-9]). Many significant findings, including the DT association, are seen exclusively in AAs. Additional recruitment of AA AD subjects with a state-of-the-art assessment is necessary. Deep phenotyping will make available other relevant related phenotypes, such as risky sexual behavior. New recruitment will build upon our existing sample to increase gene-mapping power not just for AD, but also for other substance use disorder (SUD) traits that are highly comorbid with AD in clinical populations. This resource will enable replication and a more detailed and broader investigation of identified associations. The focus on AA subjects will (a) help to address the well-recognized disparity in complex trait studies of this population; (b) allow us to follow-up GWAS results in the specific population where most of our significant results have been observed (pending future funding); and (c) increase power through greater homogeneity of the study sample. Our new subjects (pending future projects to allow genotyping and analysis based on the subjects to be collected here) will be added to the Psychiatric Genomics Consortium sample to improve the power of their SUD mega-analyses.

抽象的 在美国，酒精依赖（AD）在过去十年中大幅增加，对个人和社会来说具有高度破坏性和代价。震颤性谵妄（DT）也是一种常见且危险的疾病。我们之前进行了一项针对未充分研究的非洲裔美国人 (AA) 人群的 AD 研究项目，并进行了多项调查，包括一项开创性的 AD 全基因组关联研究 (GWAS)，我们还报告了许多相关的 GWAS。我们的研究结果包括与 AD 和相关性状相关的全基因组显着风险位点；我们的初步数据支持 UNC13C 的 DT 风险位点（P= 9.4×10[-9]）。 ，仅在 AA 中可见。 额外招募具有最先进评估的 AA AD 受试者是必要的，这将提供其他相关的相关表型，例如危险的性行为，新的招募将基于我们现有的样本，以提高基因定位能力。不仅针对 AD，而且还针对临床人群中与 AD 高度共存的其他物质使用障碍 (SUD) 特征。该资源将能够对已确定的关联进行复制和更详细、更广泛的研究。帮助解决该人群的复杂性状研究中存在公认的差异；(b) 使我们能够在已观察到大部分显着结果的特定人群中跟踪 GWAS 结果（有待未来的资助）；(c) 通过更大的力度来增强力量；我们的新受试者（未来的项目允许根据此处收集的受试者进行基因分型和分析）将被添加到精神病学基因组学联盟样本中，以提高其 SUD 的能力。大型分析。

项目成果

Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample.

深度表型样本中物质使用障碍的全表组关联分析。

• 发表时间: 2023-03-15
• 影响因子: 10.6
• 作者: Kember, Rachel L;Hartwell, Emily E;Xu, Heng;Rotenberg, James;Almasy, Laura;Zhou, Hang;Gelernter, Joel;Kranzler, Henry R
• 通讯作者: Kranzler, Henry R

Genetic influences and causal pathways shared between cannabis use disorder and other substance use traits.

大麻使用障碍和其他物质使用特征之间共有的遗传影响和因果途径。

• 发表时间: 2024-04-05
• 影响因子: 11
• 作者: Galimberti, Marco;Levey, Daniel F;Deak, Joseph D;Zhou, Hang;Stein, Murray B;Gelernter, Joel
• 通讯作者: Gelernter, Joel