AMYGDALA: SEX DIFFERENCES IN BEHAVIOR, COGNITION NEUROENDOCRINE DEVELOPMENT

杏仁核：行为、认知神经内分泌发育的性别差异

• 批准号: 7715836
• 负责人: Kim Wallen
• 金额: $ 3.56万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715836
• 关键词: Adolescent; Adult; Affect; Age; Amygdaloid structure; Anxiety; Behavior; Behavioral; Class; Cognition; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer Systems Development; Computers; Condition; Development; Discrimination; Emotional; Emotional disorder; End Point; Female; Fright; Functional disorder; Funding; Grant; Human; Institution; Lesion; Life; Macaca mulatta; Memory; Modeling; Monkeys; Nature; Neonatal; Neurodevelopmental Disorder; Neurosecretory Systems; Numbers; Psyche structure; Puberty; Range; Research; Research Personnel; Resources; Sampling; Sex Behavior; Sex Characteristics; Social Behavior; Social Conditions; Social Environment; Social Interaction; Source; Time; United States National Institutes of Health; cohort; design; gonad function; male; sex; social; social group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates sex differences in the social, emotional, cognitive and neuroendocrine consequences of neonatal and post-pubertal amygdalectomy in rhesus monkeys living in complex semi-natural social groups. Unlike the severely socially restricted conditions of previous studies, our large monkey groups have multiple matrilines and all age and sex classes allowing investigating amygdala function under social conditions it is likely designed to deal with. This project tracks the development of these systems and relates changes in juvenile function to the pubertal transition and adult social behavior. Forty-eight monkeys, distributed between 8 male and 8 female controls, 8 neonatally amygdalectomized of each sex, and 8 post-pubertally lesioned subjects of each sex, will be created in two annual cohorts of 24. Neonatal gonadal function, anxiety, fear, and maternal attachment will be assessed along with extensive observations of social interactions in the subjects' natal group during the first four years of life. At 2yr, cognitive continuously available computer kiosks will be used to assess object and spatial memory span and object discrimination. At 2yr females will be intensely sampled to assess pubertal timing as well as pubertal changes in social and sexual behavior. It is hypothesized that the different male and female natal social environments, combined with the sexually differentiated nature of amygdala function will produce different magnitudes of effect of amygdala damage, with males being more severely affected than females. We hypothesize that amygdalectomized females will uniformly show early puberty. Altered amygdala function is found in a number of neurodevelopmental disorders and while amygdalectomy does not serve as a model for any single human mental or emotional disorder, understanding its functional effects on a range of behavioral, cognitive and neuroendocrine endpoints will be invaluable for understanding the developmental trajectory of alterations produced by early amygdala dysfunction in human neurodevelopmental disorders.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目调查了生活在复杂的半自然社会群体中的恒河猴中，新生儿和后杏仁核切除术对社会，情感，认知和神经内分泌后果的性别差异。与以前的研究严重受到社会限制的条件不同，我们的大型猴子群具有多种母系，所有年龄和性别阶层允许在社会条件下调查杏仁核功能。该项目跟踪这些系统的开发，并将少年功能的变化与青春期过渡和成人社会行为联系起来。四十八只猴子，分布在8个男性和8个女性对照之间，每种性别的新生杏仁核切除术，以及每种性别后的8个后期病变后的受试者，将在两个年度的同类群体中创建。新生儿的伴侣功能，焦虑，恐惧，恐惧和孕产妇的依恋将在社交活动中进行。在2年中，认知连续可用的计算机信息亭将用于评估对象和空间内存跨度和对象歧视。在2岁的女性中，将进行大量采样，以评估青春期的时机以及社会和性行为的青春期变化。假设不同的男性和女性出生社会环境，加上杏仁核功能的性别差异化的性质将产生杏仁核损害的效果不同，而男性比女性受到更严重的影响。我们假设杏仁核切除女性将均匀地显示早期青春期。 Altered amygdala function is found in a number of neurodevelopmental disorders and while amygdalectomy does not serve as a model for any single human mental or emotional disorder, understanding its functional effects on a range of behavioral, cognitive and neuroendocrine endpoints will be invaluable for understanding the developmental trajectory of alterations produced by early amygdala dysfunction in human neurodevelopmental disorders.