BEHAVIORAL DEVELOPMENT PRENATAL HORMONAL INFLUENCES

行为发展产前荷尔蒙的影响

• 批准号: 7562508
• 负责人: Kim Wallen
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562508
• 关键词: Adult; Affect; Aging; Anatomy; Androgen Receptor; Androgen Suppression; Androgens; Animals; Behavior; Behavioral; Body Weight; Brain; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Daily; Development; Environment; Exposure to; Female; Flutamide; Funding; Grant; Hormonal; Hormones; Injection of therapeutic agent; Institutes; Institution; Longevity; MRI Scans; Macaca mulatta; Mothers; Neurosecretory Systems; Pregnancy; Research; Research Personnel; Resources; Sex Characteristics; Source; Structure; Testosterone Enanthate; Thinking; United States National Institutes of Health; Week; day; design; male; mind control; prenatal; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The early hormone environment has been thought to influence the development of male/female behavioral and neuroendocrine differences through the life span. This study exposed developing male and female rhesus monkeys to atypical prenatal hormonal environments and has been investigating their behavioral and neuroendocrine development. Treatments were designed to mimic accidental exposure to or suppression of androgens prenatally. This study investigated whether prenatal androgen exposure, social rank, and body weight are factors regulating pubertal development in female rhesus monkeys. Subjects' mothers received injections of testosterone enanthate (20 mg/week), flutamide (an androgen receptor blocker, 30 mg/kg twice daily), or vehicle during gestational days 35/40-70 (early) or days 105/110-140 (late). We investigated whether reducing endogenous T prenatally affected adult copulatory behavior in male rhesus monkeys. Treatment with flutamide early in gestation resulted in males with significantly less masculinized genitals that control males or males getting flutamide late in gestation. During the current year all of the prenatally treated males and females along with concurrent controls were MRI scanned to look for sex differences in brain anatomy. In collaboration with investigators at the National Institute of Aging, control MRI scans of males and females are being evaluated for structural sex differences. The prenatally treated animals are then being compared to the common morphed brains of control males and females to identify where prenatal treatments have modified brain structures.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 人们认为早期的激素环境会影响男性/女性行为和神经内分泌差异的发展。 这项研究使开发雄性和雌性恒河猴的猴子暴露于非典型的产前激素环境，并一直在研究其行为和神经内分泌的发育。 设计的处理是为了模仿产前的意外暴露或抑制雄激素。 这项研究调查了产前雄激素暴露，社会等级和体重是否是调节雌性恒河猴青春期发育的因素。 受试者的母亲接受了睾丸激素的注射（20毫克/周），氟非胺（雌激素受体阻滞剂，每天两次30 mg/kg）或妊娠天35/40-70（早期）或105/110-140天（晚期）。 我们调查了雄性恒河猴中会减少产前影响的成人交配行为。 妊娠早期用氟非洲胺的治疗导致男性男性的男性生殖器明显减少，这些雄性控制雄性或雄性在妊娠后期得到氟他胺。 在本年度，对所有接受过产前治疗的男性和女性以及并发控制均进行了MRI扫描，以寻找脑解剖结构的性别差异。 与美国国家老龄研究所的研究人员合作，正在评估男性和女性的控制MRI扫描是否存在结构性差异。 然后将产前治疗的动物与对照雄性和女性的常见变形大脑进行比较，以识别产前治疗改变了脑结构的位置。