AMYGDALA: SEX DIFFERENCES IN BEHAVIOR, COGNITION NEUROENDOCRINE DEVELOPMENT

杏仁核：行为、认知神经内分泌发育的性别差异

• 批准号: 8172409
• 负责人: Kim Wallen
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172409
• 关键词: Adolescent; Adult; Age; Amygdaloid structure; Anxiety; Behavior; Cognition; Cognitive; Complex; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Development; Discrimination; Emotional; Female; Fright; Funding; Grant; Institution; Life; Macaca mulatta; Memory; Menarche; Monkeys; Neonatal; Neurosecretory Systems; Performance; Primates; Process; Puberty; Research; Research Personnel; Resources; Rest; Sample Size; Sampling; Sex Behavior; Sex Characteristics; Social Behavior; Social Conditions; Social Interaction; Source; United States National Institutes of Health; behavior observation; cohort; design; gonad function; male; pubertal timing; sex; social; social group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project investigates sex differences in the social, emotional, cognitive and neuroendocrine consequences of neonatal and post-pubertal amygdalectomy in rhesus monkeys living in complex semi-natural social groups. Unlike the severely socially restricted conditions of previous studies, our large monkey groups have multiple matrilines and all age and sex classes allowing investigating amygdala function under social conditions it is likely designed to deal with. This project tracks the development of these systems and relates changes in juvenile function to the pubertal transition and adult social behavior. We have now successfully created forty-one monkey subjects in two annual cohorts, including 9 male and 8 female neonatally amygdalectomized subjects, with the other 24 subjects serving as juvenile controls. Eight male and 8 female controls will be amygdalectomized 1 year post-pubertally to allow direct comparison of the effects of neonatal and adult amygdalectomy Neonatal gonadal function, anxiety, fear, and maternal attachment are in the process of being assessed along with extensive observations of social interactions in the subjects' natal group during the first four years of life. At 2 yr, continuously available computer kiosks will be used to assess object and spatial memory span and object discrimination. Starting at 1.25yr females have been intensely sampled to assess pubertal timing as well as pubertal changes in social and sexual behavior. Surprisingly, the one neonatally amygdalectomized female in our first cohort (the rest of the amygdalectomized females were created in the second cohort completed this year) went through menarche at 1.5years, a full year earlier than any control female in our colony has gone through puberty. We have continued weekly focal observations of behavior, neonatal imitation, and LabTab performance has been collected on these subjects. Sample sizes will are now sufficient for data analysis, which is currently under way.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目调查了生活在复杂的半自然社会群体中的恒河猴中，新生儿和后杏仁核切除术对社会，情感，认知和神经内分泌后果的性别差异。与以前的研究严重受到社会限制的条件不同，我们的大型猴子群具有多种母系，所有年龄和性别阶层允许在社会条件下调查杏仁核功能。 该项目跟踪这些系统的开发，并将少年功能的变化与青春期过渡和成人社会行为联系起来。现在，我们已经成功地在两个年度组中创建了41名猴子受试者，其中包括9名男性和8位女性新生儿杏仁核切除术受试者，其他24名受试者充当少年对照。 八个男性和8位女性对照将在拟南芥后进行杏仁核切除术1年，以直接比较新生儿和成人杏仁核新生儿腺功能，焦虑，恐惧，恐惧和母体依恋的影响，并在第一个四年级的Natal Life期间进行了社交互动的广泛观察。在2年时，连续可用的计算机信息亭将用于评估对象和空间内存跨度和对象歧视。从1.25岁的女性开始进行了大量抽样，以评估青春期的时机以及社会和性行为的青春期变化。 令人惊讶的是，在我们的第一个队列中，一位新生儿杏仁核切除术的女性（其余的杏仁核切除妇女是在今年的第二次队列中创建的）经历了1.5岁的初潮，比我们殖民地的任何控制女性都早于我们的殖民地。 我们对这些受试者进行了每周对行为，新生儿模仿和LabTAB表现的焦点观察。 样本量现在足以进行数据分析，目前正在进行中。