Nutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center

精准健康营养：北卡罗来纳大学教堂山分校临床中心

基本信息

批准号：
10539342
负责人：
Elizabeth J Mayer-Davis
金额：
$ 274.79万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-10 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10539342
关键词：
Adult Advisory Committees Age All of Us Research Program American diet Anti-Inflammatory Agents Basic Science Biological Calories Carbohydrates Cardiovascular Diseases Cardiovascular system Chronic Chronic Disease Clinical Complex Creativeness Crossover Design Data Diabetes Mellitus Diet Dietary Intervention Dietary Practices Disease Enrollment Ensure Epigenetic Process Fatty acid glycerol esters Foundations Funding Genetic Genotype Goals Health Heterogeneity Individual Inflammation Inflammatory Knowledge Leadership Literature Location Longevity Malignant Neoplasms Mediterranean Diet Metabolic Molecular Morbidity - disease rate Neurodegenerative Disorders Non-Insulin-Dependent Diabetes Mellitus North Carolina Nutritional Science Nutritional Study Obesity Outcome Participant Pathogenesis Phenotype Physiological Population Precision Health Process Protocols documentation Public Health Recommendation Research Design Research Infrastructure Research Institute Risk Risk Reduction Rural Community Sampling Sampling Studies Site Subgroup Testing United States National Institutes of Health Universities Urban Community Variant Visit Weight clinical center cohort dietary dietary guidelines experience feeding health goals human old age (65+)improved individual variation inflammatory marker microbiome mortality multi-site trial neoplastic nutrition participant enrollment people of color precision nutrition prediction algorithm public health research recruit response systemic inflammatory response

项目摘要

Project Summary/Abstract – The University of North Carolina at Chapel Hill Clinical Center The need for more precise nutrition advice is widely recognized, yet specific differences in genetic, epigenetic, microbiome and phenotypic drivers of individual variability to diet are not well known. The National Institutes of Health initiative to fund Nutrition for Precision Health (NPH), powered by the All of Us Research Program, will enable major progress in the field of precision nutrition. Here we propose Nutrition for Precision Health: The University of North Carolina at Chapel Hill Clinical Center (UNC-CC). Because chronic inflammation promotes the pathogenesis of a wide range of diseases, including obesity, type 2 diabetes, and cardiovascular, neoplastic, and neurodegenerative disorders, we draw upon the anti-inflammatory Mediterranean diet as a viable strategy to improve systemic inflammation and reduce risk for many chronic diseases and their complications. A body of literature has emerged that demonstrates both genotypically- and phenotypically-driven differential responses to the Mediterranean diet relative to a range of outcomes. Our proposal will address the critical need to understand variability in physiologic responses to diet, anchored by the theme of inflammation. We emphasize inclusion of a highly diverse sample facilitated by two clinical locations with metabolic kitchens: the UNC Nutrition Research Institute (UNC-NRI) in Kannapolis, NC, and the Chapel Hill campus of UNC (UNC-CH). The UNC-NRI draws from relatively rural communities, and UNC-CH draws from relatively urban communities, both with a substantial proportion of people of color. Specific Aims are: Aim 1. To participate actively in the Year 1 planning process and beyond, engaging across the NPH consortium to collaboratively develop and execute the final study protocol. Aim 2. To execute NPH Module 1. Following participant enrollment into All of Us, we will enroll and complete the Module 1 protocol for a total of 2,000 NPH participants (25% at UNC-NRI; 75% at UNC-CH), including two study visits with a 2-week remote data capture period and a mixed meal challenge test. Aim 3. To execute NPH Module 2. A subset of 500 Module 1 participants will complete a free-living, controlled feeding study of three 2-week diet intervention periods, separated by 3-week washout periods. Diets include: the Mediterranean diet adapted for the US (Med-USA; 40% fat calories, 40% carbohydrate), the Med-USA modified for high healthy fat content (60% fat calories, 20% carbohydrate), and Med-USA modified for high healthy carbohydrate content (20% fat calories, 60% carbohydrate). Differential effects of the diets on outcomes comprising inflammatory markers and metabolic parameters from the mixed meal challenge will be tested across genotypic and phenotypic subgroups, focusing on weight status, age, and diabetes status. The UNC-CC team brings impressive interdisciplinary strength in nutrition (basic science to public health) and has the capacity and experience in complex, multi-site trials to ensure the scientific rigor needed to execute this study. Results will generate predictive algorithms to inform individualized dietary guidance to improve health.

项目摘要/摘要 - 北卡罗来纳大学教堂山临床中心人们广泛认识到需要更精确的营养建议，但遗传、表观遗传、饮食个体差异的微生物组和表型驱动因素尚不清楚。由“我们所有人研究计划”支持的资助精准健康营养 (NPH) 的健康倡议将在此我们提出精准健康营养：北卡罗来纳大学教堂山临床中心 (UNC-CC) 因为慢性炎症。促进多种疾病的发病机制，包括肥胖、2 型糖尿病和心血管疾病，对于肿瘤和神经退行性疾病，我们利用抗炎地中海饮食作为可行的方法改善全身炎症并降低许多慢性疾病及其并发症风险的策略 A。已经出现的大量文献证明了基因型和表型驱动的差异我们的建议将解决对地中海饮食的一系列影响的关键问题。需要了解对饮食的生理反应的变异性，以以下主题为基础：我们强调纳入由两个临床地点促进的高度多样化的样本代谢厨房：位于北卡罗来纳州坎纳波利斯的北卡罗来纳大学营养研究所 (UNC-NRI) 和教堂山 UNC-CH 校园 (UNC-CH) UNC-NRI 来自相对农村社区，UNC-CH 来自相对农村社区。相对城市社区，都有相当大比例的有色人种。具体目标是：目标 1. 积极参与第一年及以后的规划过程，并参与整个 NPH 联盟共同制定和执行最终的研究方案。目标 2. 执行 NPH 模块 1。在参与者注册加入 All of Us 后，我们将注册并完成模块 1 协议共有 2,000 名 NPH 参与者（25% 在 UNC-NRI；75% 在 UNC-CH），其中包括两名研究访问包括为期两周的远程数据采集期和混合膳食挑战测试。目标 3. 执行 NPH 模块 2。 500 名模块 1 参与者的子集将完成自由生活、受控的三个为期 2 周的饮食干预期（中间间隔 3 周的冲洗期）的喂养研究包括：适合美国的地中海饮食（Med-USA；40% 脂肪热量，40% 碳水化合物），Med-USA 修改版适合高健康脂肪含量（60% 脂肪热量，20% 碳水化合物），Med-USA 改良后适合高健康碳水化合物含量（20% 脂肪热量，60% 碳水化合物）。饮食对结果的不同影响。包括来自混合膳食挑战的炎症标记物和代谢参数将在各个阶段进行测试基因型和表型亚组，重点关注体重状况、年龄和糖尿病状况。 UNC-CC 团队在营养学（基础科学到公共卫生）方面带来了令人印象深刻的跨学科实力并拥有复杂的多地点试验的能力和经验，以确保执行所需的科学严谨性这项研究的结果将生成预测算法，为改善健康的个性化饮食指导提供信息。