SEARCH For Diabetes in Youth, Phase 3: Cohort Study-Carolina Center

搜索青少年糖尿病，第 3 阶段：队列研究-卡罗莱纳中心

• 批准号: 8311527
• 负责人: Elizabeth J Mayer-Davis
• 金额: $ 73.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8311527
• 关键词: SEARCH; Diabetes; Youth; Phase; Cohort

SEARCH for Diabetes in Youth (SEARCH) is an on-going, multi-center study containing the largest and most ethnically diverse population of youth with diabetes ever studied in the US. In response to RFA-DP10-001, Component B, the SEARCH Cohort Study will utilize this unique resource by continuing the study of selected SEARCH participants to address the following Aims: 1) assess the prevalence, incidence, and risk factors for selected markers of chronic microvascular (retinopathy, nephropathy, and autonomic neuropathy) and macrovascular complications (hypertension, arterial stiffness) of diabetes; 2) assess the incidence and risk factors for acute complications of diabetes including serious hypoglycemia and diabetic ketoacidosis ; 3) conduct surveillance of mortality; and 4) determine the degree to which barriers of care, quality of care, and transition to adult care impact diabetes-related health outcomes including quality of life. Overlaid across these Aims, we will focus on the impact of race/ethnicity and other sociocultural factors, and biochemical dimensions of diabetes type, on diabetes-related health outcomes. The SEARCH Cohort Study will conduct an in-person research study visit on SEARCH participants incident in 2002 or later, with duration of diabetes > 5 years and with baseline data completed (expected n=3699). During this study medical history, anthropometric, biochemical, physiologic, and survey data will be collected and analyzed. With the Dr Mayer-Davis as PI and the national chairperson for SEARCH 2, and as we have done throughout SEARCH, the Carolina Clinical Center will provide substantial scientific leadership. For the Cohort Study we bring new leadership in the areas of diabetic retinopathy and diabetic nephropathy. Importantly, the Carolina population comprises the lowest socioeconomic status among the current SEARCH sites, and over half of the African American youth in SEARCH are from the Carolina Center. Additionally, and a substantial proportion of youth with type 2 diabetes are from this Center. This study will exploit the size and ethnic diversity of the study population to identify differences in both processes of care and health outcomes by traditional, clinical diabetes type; by the major race/ethnic groups in the US; and by employing a novel approach to segregate traditional clinical diabetes types by pathophysiologic dimensions. Thus, the SEARCH cohort study has a high likelihood of making a significant impact on the clinical care of youth with diabetes from all the major ethnic groups in the US and on national public health policy.

SEARCH for Diabetes in Youth (SEARCH) 是一项持续进行的多中心研究，包含最大、最 美国曾对患有糖尿病的不同种族青少年进行过研究。响应 RFA-DP10-001， B 部分，即“搜索队列研究”将通过继续研究选定的对象来利用这一独特的资源。 SEARCH 参与者要实现以下目标：1) 评估以下疾病的患病率、发病率和风险因素： 慢性微血管病（视网膜病、肾病和自主神经病）的选定标志物和 糖尿病的大血管并发症（高血压、动脉硬化）； 2）评估发生率和风险 糖尿病急性并发症的因素，包括严重低血糖和糖尿病酮症酸中毒； 3） 进行死亡率监测； 4) 确定护理障碍、护理质量和 向成人护理的过渡会影响糖尿病相关的健康结果，包括生活质量。覆盖在这些 目标，我们将重点关注种族/民族和其他社会文化因素以及生化维度的影响 糖尿病类型，与糖尿病相关的健康结果。 SEARCH 队列研究将进行面对面的 对 2002 年或之后发生的 SEARCH 参与者事件进行研究访问，糖尿病病程 > 5 年且 基线数据已完成（预计 n=3699）。在这项研究期间，病史、人体测量学、 将收集和分析生化、生理和调查数据。以 Mayer-Davis 博士为 PI 并 SEARCH 2 的全国主席，正如我们在整个 SEARCH 中所做的那样，Carolina Clinical 中心将提供实质性的科学领导。对于队列研究，我们在这些领域带来了新的领导力 糖尿病视网膜病变和糖尿病肾病。重要的是，卡罗来纳州的人口是最低的 当前搜索网站中的社会经济地位，以及超过一半的非裔美国青年 搜索来自卡罗莱纳中心。此外，相当大比例的青少年患有 2 型糖尿病 均来自该中心。这项研究将利用研究人群的规模和种族多样性来确定 传统临床糖尿病类型的护理过程和健康结果存在差异；由主要 美国的种族/族裔群体；并采用一种新方法来分离传统的临床糖尿病 按病理生理学维度划分的类型。因此，SEARCH 队列研究很有可能做出 对美国所有主要种族的青少年糖尿病患者的临床护理产生了重大影响 国家公共卫生政策。