Clinical Center for NIH's Nutrition for Precision Health: The All Of Us New England Research Collaborative

美国国立卫生研究院精准健康营养临床中心：我们所有人新英格兰研究合作组织

基本信息

批准号：
10539337
负责人：
Sai Krupa Das
金额：
$ 189.89万
依托单位：
TUFTS UNIVERSITY BOSTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-10 至 2026-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10539337
关键词：
Address Adherence Adult Adverse event Aging Algorithms All of Us Research Program Behavioral Chronic Disease Clinical Cognitive Collaborations Community Outreach Community Participation Core Facility Coupled Cross-Over Studies DASH diet Data Development Diet Dietary Formulations Dietary Intervention Dietary Practices Dietary intake Discipline of Nursing Domiciles Enrollment Ensure Environmental Risk Factor Food Formulation Funding General Hospitals Genomics Goals Health Human Individual Individual Differences Inpatients Longevity Massachusetts Measures Metabolic Metagenomics Methods Modeling Movement New England Non-Insulin-Dependent Diabetes Mellitus Nutritional Study Oral Outcome Outcome Assessment Participant Patient Recruitments Phase Physiological Population Positioning Attribute Precision Health Productivity Protocols documentation Public Health Randomized Recommendation Records Research Resources Risk Reduction Science Site Standardization Surveys System Testing Thinking Translational Research United States Department of Agriculture United States National Institutes of Health Universities Variant Visit algorithm development biobank clinical center clinical research site clinical translation cohort contextual factors dietary dietary adherence dietary control doubly-labeled water eHealth experience feeding flexibility individual response individual variation inter-individual variation ketogenic diet metabolomics microbiome new technology non-compliance novel nutrition participant retention personalized approach population based precision nutrition prediction algorithm programs recruit response skills tool volunteer

项目摘要

PROJECT SUMMARY The All of Us New England Clinical Center (AoU-NE-CC) is a collaboration of New England–based research teams with the necessary expertise and resources in nutrition and clinical translational science to implement successfully all 3 modules of the NIH Common Fund’s Nutrition for Precision Health (NPH) Clinical Center program. The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University (Tufts- HNRCA) and Massachusetts General Hospital (MGH) will lead the AoU-NE-CC and partner with All of Us New England to ensure the diversity of participants and scientific rigor required to identify inter-individual variability of response to dietary patterns. The AoU-NE-CC is committed to All of Us core values and has implemented best practices of team science throughout its development. The AoU-NE-CC will serve as a key partner in the development of a rigorous NPH common protocol and examine habitual dietary intake (Module 1), measure physiological responses to a mixed-meal challenge (Modules 1-3), and identify responses to 3 intervention diets in both free-living (Module 2) and domiciled (Module 3) controlled feeding conditions. Coupled with standard All of Us data, the physiological responses collected through these modules will be used to develop predictive algorithms that inform precision nutrition approaches for long-term health. To attain maximum metabolic and microbiome response variability, we propose the following 14-day isocaloric diets for Modules 2 and 3, separated by 4-week washout periods: (1) a high-adherence Dietary Approaches to Stop Hypertension (DASH) diet; (2) a low-adherence DASH diet; and (3) a ketogenic diet. We also propose the use of the thoroughly tested mixed-meal challenge PhenFlex, which can be standardized across clinical centers to provide a multisystem assessment of metabolic flexibility. With its outstanding core facilities, including metabolic kitchens and domiciled feeding and nursing centers, as well as a rich legacy of conducting rigorous feeding studies, the AoU-NE-CC is uniquely skilled and positioned to serve as a clinical center for the NPH. Additional strengths of the AoU-NE-CC include extensive experience in recruiting clinical populations and biobanking, engaging volunteers through community outreach, active participation in global precision nutrition initiatives, and an outstanding track record of productive multisite collaborations in nutrition, omics, and precision health. Importantly, the Tufts-HNRCA and MGH teams are closely aligned with the All of Us New England team and its record of high participant recruitment and retention and its diverse cohort, which will support the NPH consortium goals. By partnering with NPH and All of Us in this novel modular discovery science study, the AoU-NE-CC and its experienced, forward-thinking, highly collaborative team will contribute to the development of precision nutrition approaches that support optimal health across the adult lifespan.

项目概要 All of Us 新英格兰临床中心 (AoU-NE-CC) 是新英格兰研究机构的合作项目拥有营养和临床转化科学方面必要的专业知识和资源的团队来实施成功完成 NIH 共同基金精准健康营养 (NPH) 临床中心的所有 3 个模块塔夫茨大学让·梅尔美国农业部人类营养衰老研究中心（塔夫茨- HNRCA）和麻省总医院（MGH）将领导 AoU-NE-CC 并与 All of Us New 合作英格兰确保参与者的多样性和确定个体间差异所需的科学严谨性 AoU-NE-CC 致力于我们所有人的核心价值观并已实施 AoU-NE-CC 将作为该项目的关键合作伙伴。制定严格的 NPH 通用方案并检查习惯性饮食摄入量（模块 1）、测量对混合膳食挑战的生理反应（模块 1-3），并确定对 3 种干预的反应自由生活（模块 2）和住所（模块 3）的饮食以及受控的喂养条件。我们所有人的标准数据，通过这些模块收集的生理反应将用于开发预测算法为实现长期健康提供精准营养方法。鉴于代谢和微生物组反应的变异性，我们为模块 2 提出以下 14 天等热量饮食 3、间隔 4 周的清除期：(1) 高度坚持的饮食方法来控制高血压 (DASH) 饮食；(2) 低依从性 DASH 饮食；以及 (3) 生酮饮食。经过彻底测试的混合膳食挑战 PhenFlex，可以在各个临床中心进行标准化，以凭借其出色的核心设施，包括代谢灵活性的多系统评估。代谢厨房和住所喂养和护理中心，以及进行严格的管理的丰富遗产在喂养研究方面，AoU-NE-CC 拥有独特的技能，定位为 NPH 的临床中心。 AoU-NE-CC 的其他优势包括在招募临床人群和生物样本库、通过社区外展吸引志愿者、积极参与全球精准营养倡议，以及在营养、组学和重要的是，Tufts-HNRCA 和 MGH 团队与 All of Us New 密切合作。英格兰队及其高参与者招募和保留的记录及其多元化的群体，这将通过与 NPH 和 All of Us 合作开展这一新颖的模块化发现，支持 NPH 联盟的目标。科学研究、AoU-NE-CC 及其经验丰富、具有前瞻性、高度协作的团队将做出贡献开发精确的最佳营养方法，支持成人一生的健康。