Molecular genetics of macrophage activation.

巨噬细胞激活的分子遗传学。

• 批准号: nhmrc : 252765
• 负责人: Prof David Hume
• 金额: $ 28.36万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-genetics-macrophage-activation/76849
• 关键词: Molecular; genetics; macrophage; activation.

This project concerns the basic biology of white blood cells called macrophages. Macrophages are required for the immediate defence against infection, as well as wound repair and normal turnover of tissues, but they can also produce toxic products that cause illness, especially in inflammatory diseases and cancer. We are attempting to use the availability of mouse genome information to produce a complete picture of the way that macrophages respond to a challenge from a potential disease-causing microorganism, and the influence of genetic differences between individuals.

该项目涉及称为巨噬细胞的白细胞的基本生物学。巨噬细胞是立即防御感染、伤口修复和组织正常更新所必需的，但它们也可以产生导致疾病的有毒产物，特别是在炎症性疾病和癌症中。我们正试图利用小鼠基因组信息的可用性来全面了解巨噬细胞对潜在致病微生物挑战的反应方式，以及个体之间遗传差异的影响。