Synaptic dysregulation in a mouse model of Alzheimer's disease

阿尔茨海默病小鼠模型中的突触失调

• 批准号: 8124948
• 负责人: DANIEL A NICHOLSON
• 金额: $ 23.69万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8124948
• 关键词: Address; Affect; Alzheimer' s Disease; Amyloid; Amyloid beta-Protein; Amyloid beta-Protein Precursor; Apical; Biochemical Process; Brain; Brain Diseases; Brain region; Cells; Cessation of life; Clinical; Cognition; Cognitive; Cognitive deficits; Data; Dementia; Dendrites; Disease; Electron Microscopy; Ethical Issues; Excision; Excitatory Postsynaptic Potentials; Exhibits; Exposure to; Gene Mutation; Genes; Goals; Hippocampus (Brain); Human; Impairment; Individual; Ions; Learning; Link; Location; Long-Term Depression; Long-Term Potentiation; Mediating; Membrane Potentials; Memory; Modeling; Molecular; Molecular Profiling; Morphology; Motor; Mus; Neurofibrillary Tangles; Neurons; Pathology; Pathway interactions; Patients; Peptides; Physiological; Physiology; Plant Roots; Play; Price; Property; Proteins; Regulation; Relative (related person); Resolution; Rest; Role; Running; Sampling; Series; Severity of illness; Signaling Molecule; Somatic Cell; Staging; Symptoms; Synapses; Synaptic Receptors; Synaptic Transmission; Synaptic plasticity; Time; Transgenic Mice; Vertebral column; Wild Type Mouse; age related; behavioral impairment; falls; genetic analysis; hippocampal pyramidal neuron; in vivo; insight; memory recall; mouse model; nervous system disorder; neuron loss; overexpression; patch clamp; prevent; research study; synaptic failure; synaptic function; trafficking