Mechanisms of macrophage activation by immunostimulatory DNA

免疫刺激DNA激活巨噬细胞的机制

• 批准号: nhmrc : 102521
• 负责人: Prof David Hume
• 金额: $ 15.38万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-macrophage-activation-immunostimulatory-dna/96008
• 关键词: Mechanisms; macrophage; activation; immunostimulatory; DNA

This project is based upon the observation that the mammalian immune system can distinguish between its own genetic material (DNA) and the genes of infectious agents such as bacteria. This fact has implications for understanding how the immune system copes with infection, and also for design of new therapies and vaccines. Our central aim is to define exactly how this recognition system works. The cells that respond most vigorously to foreign DNA are large white blood cells called macrophages. We aim to find the macrophage protein which binds to foreign DNA and triggers the activation of the immune system. The type of immune responses initiated by foreign DNA may be useful in treatment of allergies and cancer and for improving vaccinations.

该项目基于这样的观察：哺乳动物免疫系统可以区分其自身的遗传物质（DNA）和细菌等传染源的基因。这一事实对于理解免疫系统如何应对感染以及新疗法和疫苗的设计具有重要意义。我们的中心目标是准确定义该识别系统的工作原理。对外源 DNA 反应最强烈的细胞是称为巨噬细胞的大型白细胞。我们的目标是找到与外源 DNA 结合并触发免疫系统激活的巨噬细胞蛋白。由外来 DNA 引发的免疫反应类型可能有助于治疗过敏和癌症以及改善疫苗接种。