Affective Style: Neural and Behavioral Substrates

情感风格：神经和行为基础

• 批准号: 7357458
• 负责人: Richard J Davidson
• 金额: $ 197.61万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-04 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7357458
• 关键词: Affective; Style; Neural; Behavioral; Substrates

DESCRIPTION (provided by applicant): This application requests five years of funding to establish an Interdisciplinary Behavioral Science Center for Mental Health (IBSC). Our Center builds upon our previous Center for Behavioral Sciences Research and is focused on affective style--consistent individual differences in particular parameters of emotional reactivity and affect regulation. Why some individuals respond especially intensely and persistently to negative events while others appear considerably more resilient, is a question of profound significance to understanding vulnerability to psychopathology. Each of the projects in this Center is focused on different, but related aspects of affective style. Each of the projects converge toward an understanding of the behavioral, neural and hormonal substrates of vulnerability toward mood and anxiety disorders, with a focus on understanding the interconnected roles of different territories of prefrontal cortex, anterior cingulate cortex, amygdala and the hypothalamic-pituitary-adrenal axis (HPA) in these processes. The Center is comprised of five projects and three cores. The projects are focused on different populations including normal adults, adults at putative risk for mood and anxiety disorders based upon biological indices that reflect emotion regulation, adolescents at risk for internalizing disorders, MZ and DZ twin children well-characterized with behavioral and other measures of temperament, and rhesus monkeys also selected to differ on temperamental features that are likely to confer risk for psychopathology. The twin and adolescent samples are tested across multiple projects in both behavioral and MR imaging protocols. There are many common behavioral (supported by a Behavioral Assessment/Clinical Diagnosis Core) and biological measures (supported by a Biological Measures Core that includes MR and microPET imaging, neuroendocrine measures and psychophysiological measures) across the projects. The science proposed will significantly advance our understanding of the neural and behavioral substrates of affective style and this new knowledge will aid in the prediction, prevention and treatment of mood and anxiety disorders.

描述（由申请人提供）：本申请要求五年的资金建立跨学科的心理健康行为科学中心（IBSC）。我们的中心建立在我们先前的行为科学研究中心，并专注于情感风格 - 一致的个体差异，这些差异在情感反应性的特定参数上并影响调节。为什么有些人对负面事件特别强烈地反应，而另一些人似乎似乎更有弹性，这对于理解心理病理学脆弱性具有深远的意义。该中心的每个项目都集中在情感风格的不同但相关的方面。每个项目都融入了对情绪和焦虑症脆弱性的行为，神经和激素底物的理解，重点是理解前额叶皮质的不同领土的相互联系的作用，前扣带回皮质，杏仁核，杏仁核，下丘脑 - 下坐骨 - 肾上腺肾上腺肾上腺轴心（HPA）（HPA）（HPA）。该中心由五个项目和三个核心组成。这些项目集中在不同的人群上，包括正常成年人，基于反映情绪调节的生物学指标，对情绪的假定风险和焦虑症的风险，有内在化障碍的风险，MZ和DZ双胞胎儿童对行为和其他气质措施，rhesus Monkeys的措施以及选择性的风险有所不同。双胞胎和青少年样本在行为和MR成像方案中的多个项目中进行了测试。在整个项目中，有许多常见的行为（受到行为评估/临床诊断核心的支持）和生物学措施（由MR和MICROPET成像，神经内分泌测量和心理生理学指标的核心支持）。提出的科学将大大提高我们对情感风格的神经和行为基础的理解，而这些新知识将有助于预测，预防和治疗情绪和焦虑症。

项目成果

Regulation of the neural circuitry of emotion by compassion meditation: effects of meditative expertise.

• DOI: 10.1371/journal.pone.0001897
• 发表时间: 2008-03-26
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Lutz, Antoine;Brefczynski-Lewis, Julie;Johnstone, Tom;Davidson, Richard J.
• 通讯作者: Davidson, Richard J.

A tale of two negatives: differential memory modulation by threat-related facial expressions.

• DOI: 10.1037/a0021625
• 发表时间: 2011-06
• 期刊: EMOTION
• 影响因子: 4.2
• 作者: Davis, F. Caroline;Somerville, Leah H.;Ruberry, Erika J.;Berry, Andrew B. L.;Shin, Lisa M.;Whalen, Paul J.
• 通讯作者: Whalen, Paul J.

Corrugator muscle responses are associated with individual differences in positivity-negativity bias.

• DOI: 10.1037/a0016819
• 发表时间: 2009-10
• 期刊: EMOTION
• 影响因子: 4.2
• 作者: Neta, Maital;Norris, Catherine J.;Whalen, Paul J.
• 通讯作者: Whalen, Paul J.

Mental training affects distribution of limited brain resources.

• DOI: 10.1371/journal.pbio.0050138
• 发表时间: 2007-06
• 期刊: PLoS biology
• 影响因子: 9.8
• 作者: Slagter HA;Lutz A;Greischar LL;Francis AD;Nieuwenhuis S;Davis JM;Davidson RJ
• 通讯作者: Davidson RJ

Mental training enhances attentional stability: neural and behavioral evidence.

• DOI: 10.1523/jneurosci.1614-09.2009
• 发表时间: 2009-10-21
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Lutz A;Slagter HA;Rawlings NB;Francis AD;Greischar LL;Davidson RJ
• 通讯作者: Davidson RJ