Recombinant Vaccines for Prevention of AIDS and Other Diseases

用于预防艾滋病和其他疾病的重组疫苗

• 批准号: 7732452
• 负责人: BERNARD MOSS
• 金额: $ 125.69万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7732452
• 关键词: AIDS prevention; Adverse effects; Animals; Antigens; Avian Influenza A Virus; Cellular Immunity; DNA; Disease; HIV vaccine; Life; Recombinant Proteins; Recombinant Vaccines; Research; Testing; Vaccines; Viral; Viral Antigens; Work; nonhuman primate; recombinant virus vaccine

There are many diseases for which there are no vaccines and others for which the vaccines are not optimal or have significant side effects. The objectives of this project are to characterize viral antigens, determine targets of humoral and cell mediated immunity, and use this information to develop candidate vaccines. Live recombinant viral vaccines, DNA vaccines and recombinant protein vaccines are being developed. The vaccines are first tested in small animals and then in non-human primates. Presently we are working on vaccines for HIV and avian influenza virus.

有许多疾病没有疫苗，而其他疾病的疫苗不是最佳的或有显着的副作用。 该项目的目标是表征病毒抗原，确定体液和细胞介导免疫的靶标，并利用这些信息开发候选疫苗。重组病毒活疫苗、DNA疫苗和重组蛋白疫苗正在开发中。这些疫苗首先在小动物中进行测试，然后在非人类灵长类动物中进行测试。目前我们正在研究艾滋病毒和禽流感病毒的疫苗。

项目成果

Comparative immunogenicity in rhesus monkeys of multi-protein HIV-1 (CRF02_AG) DNA/MVA vaccines expressing mature and immature VLPs.

表达成熟和未成熟 VLP 的多蛋白 HIV-1 (CRF02_AG) DNA/MVA 疫苗在恒河猴中的免疫原性比较。

• DOI: 10.1016/j.virol.2005.06.014
• 发表时间: 2005
• 期刊: Virology.
• 作者: Ellenberger,Dennis;Wyatt,Linda;Li,Bin;Buge,Suzan;Lanier,Nattawan;Rodriguez,IVanesssa;Sariol,CarlosA;Martinez,Melween;Monsour,Michael;Vogt,Jennifer;Smith,James;Otten,Ronald;Montefiori,David;Kraiselburd,Edmundo;Moss,Bernard;R
• 通讯作者: R

Correlation of immunogenicities and in vitro expression levels of recombinant modified vaccinia virus Ankara HIV vaccines.

• DOI: 10.1016/j.vaccine.2007.11.036
• 发表时间: 2008-01
• 期刊: Vaccine
• 影响因子: 5.5
• 作者: L. Wyatt;P. Earl;J. Vogt;L. Eller;D. Chandran;Jinyan Liu;H. Robinson;B. Moss

T cell responses to respiratory syncytial virus fusion and attachment proteins in human peripheral blood mononuclear cells.

• DOI: 10.1089/vim.2006.19.669
• 发表时间: 2006-12
• 期刊: Viral immunology
• 影响因子: 2.2
• 作者: L. D. de Waal;Y. Süzer;L. Wyatt;K. Sintnicolaas;G. Sutter;B. Moss;A. Osterhaus;R. D. de Swart

Promoting trimerization of soluble human immunodeficiency virus type 1 (HIV-1) Env through the use of HIV-1/simian immunodeficiency virus chimeras.

通过使用 HIV-1/猿猴免疫缺陷病毒嵌合体促进可溶性人类免疫缺陷病毒 1 型 (HIV-1) Env 的三聚化。

• DOI: 10.1128/jvi.78.5.2265-2276.2004
• 发表时间: 2004
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Center,RobJ;Lebowitz,Jacob;Leapman,RichardD;Moss,Bernard
• 通讯作者: Moss,Bernard

Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein.

• DOI: 10.1016/j.virol.2005.01.042
• 发表时间: 2005-04-10
• 期刊: Virology
• 影响因子: 3.7
• 作者: Bisht H;Roberts A;Vogel L;Subbarao K;Moss B
• 通讯作者: Moss B