Effects of binge alcohol drinking on synaptic computing in the nucleus accumbens

酗酒对伏隔核突触计算的影响

基本信息

批准号：
10523867
负责人：
Gilles E MARTIN
金额：
$ 7.2万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10523867
关键词：
Acute Administrative Supplement Adolescence Adolescent Adult Affect Affective Age Alcohol consumption Alcohol dependence Alcohols Amygdaloid structure Animals Applications Grants Aversive Stimulus Behavior Brain Categories Chronic Cognitive Communication Consumption Data Decision Making Electrophysiology (science)Emotional Equilibrium Ethanol Funding Glutamates Goals Impulsivity In Vitro Individual Judgment Laboratories Laser Scanning Microscopy Learning Link Mediating Modeling Mus Neurons Nucleus Accumbens Opsin Oral Pathway interactions Pharmaceutical Preparations Pharmacological Treatment Phase Play Prefrontal Cortex Process Property Prosencephalon Research Project Grants Research Support Rewards Role Signal Transduction Slice Structure Synapses System Technical Expertise Techniques Testing Training Transgenic Mice Translating Wild Type Mouse age related alcohol effect alcohol exposure base binge drinking biophysical techniques cognitive computing drinking drug of abuse executive function experimental study graduate student hippocampal pyramidal neuron improved insight medical schools mouse genetics nervous system disorder neural circuit neurochemistry neuronal excitability novel optogenetics patch clamp skills theories two-photon

项目摘要

This admistrative supplement research grant is seeking funding to train Timmy Le, a UMass Medical School graduate student eligible under the NOT-OD-20-031 Underrepresented Categories B and C. The ambition of this administrative supplement grant proposal is to identify the cellular underpinnings of the early transition between casual to sustain drinking using drinking-in-the-dark model. Over the course of this project, Timmy le will learn to use and implement a variety of complementary approaches, including mouse genetics, optogenetics, behavior and biophysical approaches to test the overarching hypothesis that computing of the synaptic strength of cortical and amygdala inputs (a phenomenon also known as synaptic gating) is a mechanism enabling nucleus accumbens medium spiny neurons to integrate cognitive and emotional information, and is modulated by alcohol exposure to control consumption. In addition to acquiring new technical skills, he will also receive intense training in conceptual aspects of drugs of abuse and in oral and written presentation skills.

这项行政补充研究拨款正在寻求资金来培训麻省大学医学院的蒂米·勒（Timmy Le）符合 NOT-OD-20-031 代表性不足类别 B 和资格的学校研究生 C. 这项行政补充拨款提案的目标是确定细胞从随意饮酒到黑暗饮酒的早期过渡的基础模型。在这个项目的过程中，Timmy le 将学习使用和实施各种补充方法，包括小鼠遗传学、光遗传学、行为学和生物物理学测试总体假设的方法，即计算皮质突触强度杏仁核输入（一种也称为突触门控的现象）是一种机制伏隔核中型多棘神经元整合认知和情感信息，以及通过酒精暴露来调节以控制消费。除了获取新技术技能方面，他还将接受滥用药物概念方面以及口头和书面表达技巧。