Medical Scientist Training Program

医学科学家培训计划

基本信息

批准号：
10651825
负责人：
STEVEN L REINER
金额：
$ 150.94万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10651825
关键词：
Medical Scientist Training Programs

项目摘要

ABSTRACT The central mission of the Medical Scientist Training Program (MSTP) at Columbia University's Vagelos College of Physicians and Surgeons (VP&S) is to train clinician-scientists to become leaders in biomedical research. Growing complexity of medicine and science has made it challenging to sustain a robust pipeline of clinician-scientists into the biomedical workforce. The VP&S MSTP has implemented efficiencies to integrate medical and PhD research training that keep pace with the interdisciplinary, quantitative, collaborative, and diverse nature of biomedical scholarship. The VP&S MSTP has evolved a flexible curricular model, providing outstanding and efficient training and mentorship to support the output of committed, clinically fluent, biomedical researchers. Trainees undertake an 18-month preclinical medical curriculum followed by 2 clinical clerkships, then PhD research for 3.5-4.5 years, and finally the major block of clinical clerkships. Because of MSTP's emphasis on integration, preclinical students are engaged in PhD courses and lab rotations; and PhD students are engaged in a unique clinical competence program. After the 7 or 8 year MD-PhD program, trainees emerge as creative, rigorous, diligent, resilient scientists who are also exceptional and compassionate clinicians. Specific missions of VP&S MSTP include: 1) Enhancing reproducibility of biomedical research results through training in scientific rigor and transparency; 2) Promoting a training culture with highest standards to ensure the safety, ethics, and well-being of all; 3) Imparting appreciation and ability to work in diverse teams and cultivate inclusivity; and 4) Nurturing superb skills to communicate scientific findings to a wide range of audiences. Critical enhancements to the VP&S MSTP include abundant career mentoring to promote successful transition into dual-degree careers; training in rigorous research design, as well as quantitative, computational and statistical methods; and nurturing of ethics, responsibility, diversity, and inclusivity in biomedical research and clinical practice. The trainee cohort is superb and increasingly diverse. More than 130 outstanding investigators act as thesis mentors. Program leadership has decades of graduate and medical education experience. The duration of trainee appointments would be for the first 2 years of PhD research, and the projected number of trainees across all cohorts would be 116 students. Measurable objectives that VP&S MSTP intends to achieve are: 1) Maintaining or improving high levels of dual-degree attainment (98%) and rapid time to completion (7.7 years); 2) Increasing the frequency of rigorous, impactful, first-authored papers from 93% up to 100%; 3) Bettering the 5-yr average of underrepresented racial and ethnic minority trainees (23%) to a steady 30%; and 4) Inspiring post-grad training that will increase long-term alumni retention in research careers (70%) up to 80%. VP&S MSTP graduates genuinely learn how to discover new knowledge, translate discoveries to the clinic, and then guide others through this critical mission.

抽象的哥伦比亚大学 Vagelos 医学科学家培训计划 (MSTP) 的中心任务内科医生和外科医生学院（VP＆S）旨在培训临床医生科学家成为生物医学领域的领导者研究。医学和科学的日益复杂性使得维持强大的管道变得充满挑战临床医生科学家进入生物医学队伍。 VP&S MSTP 已实现高效集成医学和博士研究培训与跨学科、定量、协作和生物医学学术的多样性。 VP&S MSTP 发展了灵活的课程模型，提供出色而高效的培训和指导，以支持忠诚、临床流利、生物医学研究人员。学员接受为期 18 个月的临床前医学课程，随后进行 2 门临床课程见习，然后是 3.5-4.5 年的博士研究，最后是临床见习的主要部分。由于 MSTP强调整合，临床前学生从事博士课程和实验室轮转；和博士学生参与独特的临床能力课程。经过 7 年或 8 年的 MD-PhD 课程后，学员将成为富有创造力、严谨、勤奋、坚韧的科学家，同时也是杰出且富有同情心的科学家临床医生。 VP&S MSTP 的具体使命包括： 1) 提高生物医学研究的可重复性通过科学严谨和透明的培训取得成果； 2) 弘扬最高水平的培训文化确保所有人的安全、道德和福祉的标准； 3) 传授欣赏和工作能力多元化的团队并培养包容性； 4) 培养向公众传达科学发现的高超技能受众范围广泛。 VP&S MSTP 的关键增强包括丰富的职业指导促进成功过渡到双学位职业；严格的研究设计培训，以及定量、计算和统计方法；以及培养道德、责任、多样性和生物医学研究和临床实践的包容性。学员队伍非常出色，而且越来越多样化。 130余名优秀研究者担任论文导师。项目领导拥有数十年的毕业生和医学教育经验。实习生任命期限为博士生的前两年研究，预计所有队列的受训人员人数将为 116 名学生。可测量的 VP&S MSTP 想要实现的目标是： 1) 维持或提高双学位的高水平成就（98%）和快速完成时间（7.7 年）； 2) 增加严格的、有影响力的、第一作者论文比例从 93% 到 100%； 3) 提高代表性不足的种族和群体的 5 年平均水平少数民族学员（23%）稳定增至30%； 4) 鼓舞人心的研究生培训，将增加长期校友在研究职业中的保留率 (70%) 高达 80%。 VP&S MSTP 毕业生真正学习如何发现新知识，将发现转化为临床，然后指导其他人完成这一关键任务。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Genome editing with retroelements.

使用逆转录元素进行基因组编辑。

DOI：
发表时间：
2023-10-27
期刊：
影响因子：
0
作者：
Tang, Stephen;Sternberg, Samuel H
通讯作者：
Sternberg, Samuel H

Transposon-encoded nucleases use guide RNAs to promote their selfish spread.

转座子编码的核酸酶使用引导 RNA 来促进其自私传播。

DOI：
发表时间：
2023-10
期刊：
影响因子：
64.8
作者：
Meers, Chance;Le, Hoang C;Pesari, Sanjana R;Hoffmann, Florian T;Walker, Matt W G;Gezelle, Jeanine;Tang, Stephen;Sternberg, Samuel H
通讯作者：
Sternberg, Samuel H

Emergence of RNA-guided transcription factors via domestication of transposon-encoded TnpB nucleases.

通过转座子编码的 TnpB 核酸酶的驯化而出现 RNA 引导的转录因子。

DOI：
发表时间：
2023-11-30
期刊：
影响因子：
0
作者：
Wiegand, Tanner;Hoffmann, Florian T;Walker, Matt W G;Tang, Stephen;Richard, Egill;Le, Hoang C;Meers, Chance;Sternberg, Samuel H
通讯作者：
Sternberg, Samuel H

Antagonistic conflict between transposon-encoded introns and guide RNAs.

转座子编码的内含子和引导RNA之间的拮抗冲突。

DOI：
发表时间：
2023-11-20
期刊：
影响因子：
0
作者：
Žedaveinytė, Rimantė;Meers, Chance;Le, Hoang C;Mortman, Edan E;Tang, Stephen;Lampe, George D;Pesari, Sanjana R;Gelsinger, Diego R;Wiegand, Tanner;Sternberg, Samuel H
通讯作者：
Sternberg, Samuel H