Diversifying and Regenerating T Cell Function

T 细胞功能多样化和再生

基本信息

批准号：
9285723
负责人：
STEVEN L REINER
金额：
$ 40万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9285723
关键词：
Adopted Antigens BLR1 gene Behavior Biological CD4 Positive T Lymphocytes CD8-Positive T-Lymphocytes CD8B1 gene Cell division Cell physiology Cells Characteristics Chronic Communicable Diseases Daughter Effector Cell Epithelial Exhibits Failure Genetic Transcription Genus Mentha Germ Heterogeneity Host Defense IL2RA gene Image Immune response Immunity Impairment Infection Laboratories Lead Leukocytes Life Listeria monocytogenes Listeriosis Malignant Neoplasms Memory Methodology Microbe Morphology Mus Mutant Strains Mice Natural regeneration Nature Phenotype Play Process Reporter Role Siblings Signal Transduction Stem cells Stream Surface T memory cell T-Lymphocyte Taxes Testing Viral adult stem cell atypical protein kinase C comparative daughter cell exhaustion fighting high resolution imaging novel novel strategies pathogen premature progenitor public health relevance regenerative response segregation stem-like cell virtual

项目摘要

DESCRIPTION (provided by applicant): T lymphocytes play a critical role in host defense against microbes and cancer. A remarkable feature of the signals that trigger T cell participation in the immune response is that every cell appears to have a mandate that assures its daughters will not uniformly adopt the same fate. This proposal develops novel methodologies to image the characteristics of dividing T cells during the course of an infectious disease. The aims of the project are to test the importance of unequal cellular inheritance in the earliest stages of the immune response, where an abundance of cell fate decisions are being made (Aim 1), in the re-challenge response wherein memory T cells may be mimicking the regenerative behavior of adult stem cells (Aim 2), and in chronic infection because this scenario may tax the regenerative limits of normal memory T cells (Aim 3). The studies proposed herein should offer novel approaches for maintaining lifelong immunity against chronic infections and for eliminating many life-threatening infectious diseases.

描述（由申请人提供）：T 淋巴细胞在宿主防御微生物和癌症方面发挥着关键作用。触发 T 细胞参与免疫反应的信号的一个显着特征是，每个细胞似乎都有一项任务，确保其子细胞不会一律采取相同的命运。该提案开发了新的方法来对传染病过程中分裂的 T 细胞的特征进行成像。该组织的目标该项目的目的是测试免疫反应早期阶段细胞遗传不平等的重要性，在免疫反应的早期阶段，大量的细胞命运决定正在发生（目标 1），在记忆 T 细胞可能模仿再生行为的再攻击反应中成体干细胞（目标 2），以及慢性感染，因为这种情况可能会加重正常记忆 T 细胞的再生极限（目标 3）。本文提出的研究应该为维持针对慢性感染的终生免疫力和消除许多危及生命的传染病提供新的方法。