Developing and Improving Institutional Animal Resources

开发和改善机构动物资源

• 批准号: 7629539
• 负责人: SAMUEL Corbin CARTNER
• 金额: $ 49.91万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-13 至 2011-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7629539
• 关键词: Alabama; Anemia; Animal Housing; Animals; Area; Biomedical Research; Breeding; Canis familiaris; Commit; Cyclic Neutropenia; Data; Exercise; Faculty; Family suidae; Goals; Hematological Disease; Hemophilia A; Housing; Human Resources; Institution; Recruitment Activity; Research; Research Personnel; Resources; Schedule; Stem cells; Universities; Workplace; animal care; animal facility; animal resource; cooking; cost; improved; mental health personnel; nonhuman primate; programs

DESCRIPTION (provided by applicant): Vital biomedical research and integrity of scientific data depend on excellent animal care. The University of Alabama at Birmingham (UAB) Animal Care and Use Program is committed to the long-term goals of providing and maintaining consistently high quality, healthy animals according to accepted standards at reasonable cost while providing a safe and healthy workplace for personnel. Recent faculty recruits using large animals and continued existing research programs has resulted in a severe large animal housing crisis. The specific aims of this application are to (1) maintain healthy large animals (dogs, nonhuman primates, pigs), by providing appropriate housing for large animals, with access to outdoor exercise areas for dogs; (2) Enrich personnel mental health allowing opportunity for dogs with which they have bonded to exercise outdoors and (3) contain costs for investigators by the renovation/reactivation of 5000 nsf of large animal housing and support space (Cook Springs Large Animal Facility, CSLAF). This additional space will allow long term housing of a dog breeding colony (30-40 dogs) that is a valuable national resource, Canine Blood Disorders and Stem Cell Resource (CBD&SCR). The CBD&SCR provides resources to investigators (UAB and other institutions) studying mechanisms and treatments of hemophilia, anemia, and cyclic hematopoiesis. The accommodation of this colony in the renovated space will allow existing UAB large animal researchers to maintain research schedules. Twenty-one UAB investigators and 10 investigators at other institutions with 61 PHS projects ($22.3 M annual, active) and 19 pending projects ($22.2M) will benefit from the proposed renovation.

描述（由申请人提供）：重要的生物医学研究和科学数据的完整性取决于出色的动物护理。阿拉巴马大学伯明翰分校 (UAB) 动物护理和使用计划致力于实现长期目标，即按照公认的标准，以合理的成本提供和维持始终如一的高质量、健康的动物，同时为人员提供安全、健康的工作场所。最近使用大型动物招募教师和继续现有的研究项目导致了严重的大型动物饲养危机。该应用程序的具体目标是（1）通过为大型动物提供适当的住房并为狗提供户外运动区域，维持大型动物（狗、非人类灵长类动物、猪）的健康； (2) 丰富人员心理健康，让与他们有联系的狗有机会进行户外锻炼；(3) 通过翻修/重新启用 5000 纳平方英尺的大型动物住房和支持空间（Cook Springs 大型动物设施，CSLAF）来控制调查人员的成本）。这个额外的空间将允许长期安置狗繁殖群（30-40 只狗），这是宝贵的国家资源、犬血液疾病和干细胞资源 (CBD&SCR)。 CBD&SCR 为研究血友病、贫血和循环造血机制和治疗的研究人员（UAB 和其他机构）提供资源。该群体在翻新后的空间内的住宿将使现有的 UAB 大型动物研究人员能够维持研究计划。 21 名 UAB 调查员和其他机构的 10 名调查员将受益于拟议的翻修，这些调查员有 61 个 PHS 项目（每年 2230 万美元，活跃）和 19 个待定项目（2220 万美元）。

项目成果

Hydrogen-bonded multilayers of tannic acid as mediators of T-cell immunity.

• DOI: 10.1002/adhm.201400657
• 发表时间: 2015-04-02
• 期刊: ADVANCED HEALTHCARE MATERIALS
• 影响因子: 10
• 作者: Kozlovskaya, Veronika;Xue, Bing;Lei, Weiqi;Padgett, Lindsey E.;Tse, Hubert M.;Kharlampieva, Eugenia
• 通讯作者: Kharlampieva, Eugenia