FASEB SRC on Helicases and nucleic acid-based machines: Structure, mechanism, regulation, and roles in human diseasesg

FASEB SRC 关于解旋酶和核酸机器：结构、机制、调节和在人类疾病中的作用g

基本信息

批准号：
9762387
负责人：
Rick Russell
金额：
$ 0.45万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-06-01 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9762387
关键词：
Address Aging American Animal Model Area Baltimore Base Pairing Binding Proteins Biochemical Biological Biological Process Biology Biophysics Bloom Syndrome Caring Cell physiology Cells Child Clustered Regularly Interspaced Short Palindromic Repeats Cockayne Syndrome Collaborations Colorado Complex Crohn&apos s disease DNA DNA Repair DNA biosynthesis Defect Development Diagnosis Disabled Persons Disease Dyskeratosis Congenita Electronic Mail Ensure Enzymes Eye Family Fanconi&apos s Anemia Fees Fostering Functional disorder Gene Expression Genetic Genetic Diseases Genetic Recombination Genome Stability Genomic Instability Germany Goals Health Homeostasis Housing Human In Vitro Information Technology Journals Knowledge Learning Link Logistics Malignant Neoplasms Mentors Molecular Molecular Conformation Molecular Machines Molecular Motors Nature Newsletter Nucleic Acids Nucleotides Ophthalmoplegia Participant Pathway interactions Phenotype Physiological Predisposition Premature aging syndrome Process Property Proteins Publishing RNA RNA Helicase RNA Interference RNA Splicing RNA Transport Regulation Request for Applications Research Research Personnel Resort Resources Role Rothmund-Thomson syndrome Science Scientific Societies Scientist Services Site Site-Directed Mutagenesis Societies Structural Protein Structure Substrate Specificity Syndrome System Techniques Texas Time Trichothiodystrophy Underrepresented Groups Underrepresented Minority United States National Institutes of Health Universities Werner Syndrome Woman Xeroderma Pigmentosum age related austin base collaborative environment graduate student helicase human disease improved in vivo innovation live cell imaging meetings nucleic acid metabolism nucleoside triphosphatase posters programs protein structure reconstitution repaired single molecule small molecule symposium therapeutic development training opportunity

项目摘要

Project Summary Abstract This application requests support for the 2019 science research conference on “Helicases and Nucleic acid-based machines: Structure, mechanism, regulation, and roles in human diseases”. The meeting is sponsored by the Federation of American Societies for Experimental Biology (FASEB) and will take place from July 21-26, 2019, in Steamboat Springs, Colorado. The conference is being organized by Rick Russell (University of Texas, Austin, USA), Robert Brosh (NIA- NIH, Baltimore, USA), and Caroline Kisker (University of Würzburg, Germany). A defining property of DNA and RNA is the stability of its base pairs, and consequently helicase enzymes are integral components of a wide range of nucleic acid processing machines. Their activities in unwinding DNA and RNA, as well as in remodeling protein-nucleic acid complexes, underlie every step of nucleic acid metabolism and the transfer of information from DNA to RNAs and proteins. Defects in these enzymes are associated with a broad spectrum of human diseases including cancer and premature aging. The critical roles of helicases in the regulation of DNA replication, repair, recombination and gene expression and their dysregulation in many diseases, and the breadth of the experimental approaches requires a robust exchange of information among the diverse group of scientists studying the structure, regulation, molecular and cellular functions, and disease-processes associated with helicases. The 11th bi-annual meeting on helicases and nucleic acid-based machines will address this need. The scientific topics at the meeting will range from structural and functional studies that deepen our knowledge of the basic principles through which helicases function all the way to how helicases contribute to the functions of key nucleic acid-based machines and how this knowledge can be exploited to improve human health. With this focus and range, this meeting has unique value for researchers studying a range of biological processes. An innovative format for professional development sessions geared towards women in science and young investigators will also provide a valuable service for these groups. Overall, the meeting will be organized to promote robust and efficient exchange of ideas and information across scientific areas and between established and new investigators in all areas of helicase structure, mechanism, regulation, and roles in human diseases.

项目概要摘要本申请请求支持2019年“解旋酶与解旋酶”科学研究会议基于核酸的机器：结构、机制、调节和在人类中的作用该会议由美国实验学会联合会主办。生物学 (FASEB) 将于 2019 年 7 月 21 日至 26 日在科罗拉多州斯廷博特斯普林斯举行。会议由 Rick Russell（美国奥斯汀德克萨斯大学）、Robert Brosh（NIA- NIH，美国巴尔的摩）和 Caroline Kisker（德国维尔茨堡大学）。 DNA 和 RNA 的一个决定性特性是其碱基对的稳定性，因此解旋酶也具有稳定性酶是多种核酸加工机器的组成部分。解旋 DNA 和 RNA 以及重塑蛋白质-核酸复合物的活性，是核酸代谢每一步以及从 DNA 到 RNA 的信息传递的基础这些酶的缺陷与多种人类疾病有关。包括癌症和过早衰老。解旋酶在 DNA 复制、修复、重组和基因调节中的关键作用许多疾病中的表达及其失调，以及实验方法的广度需要研究该问题的不同科学家群体之间进行强有力的信息交流结构、调节、分子和细胞功能以及与相关的疾病过程第 11 届解旋酶和核酸机器双年度会议将讨论这一问题。会议的科学主题将涵盖深化的结构和功能研究。我们对解旋酶发挥作用的基本原理以及解旋酶如何发挥作用的了解对基于核酸的关键机器的功能做出贡献以及如何将这些知识凭借这一重点和范围，本次会议具有独特的价值。研究人员研究一系列生物过程的创新形式。针对科学界女性和年轻研究者的发展会议也将提供总体而言，组织这次会议的目的是促进强有力的和有价值的服务。跨科学领域以及现有和新领域之间的有效交流思想和信息解旋酶结构、机制、调节和在人类疾病中的作用的所有领域的研究人员。