Developing and Improving Institutional Animal Resources

开发和改善机构动物资源

• 批准号: 7433110
• 负责人: SAMUEL Corbin CARTNER
• 金额: $ 50万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433110
• 关键词: Alabama; Animals; Biomedical Research; Censuses; Commit; Daily; Data; Diabetes Mellitus; Equipment; Funding; Goals; Growth; Health Personnel; Human Resources; Immune System Diseases; Interdisciplinary Study; Learning; Malignant Neoplasms; Memory; Mus; Neurodegenerative Disorders; Rattus; Research; Research Infrastructure; Research Personnel; Standards of Weights and Measures; System; United States Public Health Service; Universities; Workplace; animal care; animal resource; cost; improved; interest; programs; vaccine development

DESCRIPTION (provided by applicant): Vital biomedical research and integrity of scientific data depend on excellent animal care. The University of Alabama at Birmingham (UAB) Animal Care and Use Program is committed to the long-term goals of providing and maintaining consistently high quality, healthy animals according to accepted standards at reasonable cost while providing a safe and healthy workplace for personnel. The specific aims of this application are to (1) maintain healthy mice and rats, (2) protect personnel health, and (3) contain costs for Public Health Service (PHS) funded investigators at UAB. The equipment requested (12 individually ventilated caging systems (IVCSs) for mice, 16 IVCSs for rats, and 10 ventilated animal transfer stations) will assist in attaining these long term goals and the specific aims of this proposal. Sixty-one investigators with 101 PHS projects providing $24.5 million in annual active funding and 87 pending projects requesting $83.1 million in total pending funding will benefit from the requested equipment. The investigators who will directly benefit from this proposal have federal funding that supports diverse research interests with translational applicability to cancer, diabetes, vaccine development, immune disease, neurodegenerative disorders, and learning and memory. Fifty-five of these investigators, representing approximately 20 departments have a combined average daily census of 1032 cages of rats. Eighteen investigators representing four departments have a combined average daily census of 2835 cages of mice. The requested equipment will be a part of the infrastructure needed to maintain and support the growth of a nationally and internationally recognized interdisciplinary research program.

描述（由申请人提供）：重要的生物医学研究和科学数据的完整性取决于出色的动物护理。阿拉巴马大学伯明翰分校 (UAB) 动物护理和使用计划致力于实现长期目标，即按照公认的标准，以合理的成本提供和维持始终如一的高质量、健康的动物，同时为人员提供安全、健康的工作场所。该应用程序的具体目标是 (1) 维持健康的小鼠和大鼠，(2) 保护人员健康，以及 (3) 控制 UAB 公共卫生服务 (PHS) 资助的研究人员的费用。所需的设备（12 个小鼠独立通风笼养系统 (IVCS)、16 个大鼠 IVCS 和 10 个通风动物转运站）将有助于实现这些长期目标和本提案的具体目标。 101 个 PHS 项目的 61 名研究人员将受益于所请求的设备，这些项目每年提供 2450 万美元的主动资金，87 个待决项目要求总计 8310 万美元的待决资金。将直接受益于该提案的研究人员将获得联邦资助，支持各种研究兴趣，并可转化为癌症、糖尿病、疫苗开发、免疫疾病、神经退行性疾病以及学习和记忆等领域的应用。其中代表大约 20 个部门的 55 名调查员平均每天对 1032 个笼子的老鼠进行普查。代表四个部门的 18 名调查员平均每天对 2835 个笼子里的老鼠进行普查。所需的设备将成为维持和支持国内和国际认可的跨学科研究计划发展所需的基础设施的一部分。