Bulk Dry Heat Sterilizer in Zeigler Building at UAB

UAB 齐格勒大楼的散装干热灭菌器

基本信息

批准号：
10716008
负责人：
DAVID C SCHWEBEL
金额：
$ 35万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2024-07-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10716008
关键词：
Administrator Aging Alabama Animal Behavior Animal Experimentation Animals Award Back Biomedical Research Cancer Survivor Cardiac health Cartilage Chinchilla (genus)Cilia Complex Consumption Data Dedications Development Disease Dryness Elevator Employee Ensure Environment Epigenetic Process Equipment Equity Faculty Ferrets Floor Fructose Funding Funding Agency Goals Grant Growth Health Heart Human Hygiene Impact evaluation Infrastructure Laboratories Logistics Maintenance Measurement Memory Memory Disorders Modernization Molecular Mus Muscular Dystrophies Nervous System Physiology Pathology Pharmaceutical Preparations Principal Investigator Proteins Rana Rattus Reporting Reproducibility Request for Proposals Research Research Infrastructure Research Personnel Risk Risk Reduction Role Sample Size Sanitation Science Scientific Advances and Accomplishments Scientist Services Site Soil Steam Sterilization System Technology Training United States National Institutes of Health Universities Water animal colony animal resource cardiovascular health chemobrain drug development energy efficiency experience healing improved innovation interest member operation pathogen prevent programs research facility risk mitigation shift work

项目摘要

Bulk Dry Heat Sterilizer in Zeigler Building at UAB UAB (University of Alabama at Birmingham) has experienced rapid research growth and currently ranks among the top 25 universities nationally in NIH funding. This proposal requests funding to purchase a bulk dry heat sterilizer to serve the vivarium in the Zeigler Building, located in the heart of UAB’s biomedical research campus. Serving the 71 animal researchers based in the Zeigler vivarium, it will enable point-of-use sterilization and mitigate risk of contamination to pre-sterilized caging transported by truck from a different campus building. The equipment will create a modernized, green, and more rigorous research environment for the science conducted in Zeigler, UAB’s second-largest vivarium, plus the countless research programs we expect to be based in Zeigler in the decades to come. UAB uses 3 centralized cage-wash facilities to serve 12 campus vivariums. This strategy offers efficient logistics to clean and sterilize large volumes of soiled cages but impacts scientific rigor because sterilized cages are transported by truck from a cage-wash and steam-powered autoclave facility in a different building back to Zeigler. The purchase of this sterilizer will mitigate contamination risk from that transport, modernize facilities and meet sustainability goals. The scientific innovation occurring in Zeigler’s vivarium is wide-ranging and impressive. Quantitatively, the sterilizer will serve 71 Principal Investigators from 17 academic departments, 58 of them NIH-funded with >$28M in awards in the current fiscal year. The vivarium houses about 4500 cages, mostly mice and rats but also including ferrets, frogs, and chinchillas. Examples of pioneering science occurring in the vivarium include efforts to treat muscular dystrophy, prevent “chemobrain”, understand the effect of high fructose corn syrup on neurological functioning, examine epigenetic effects on memory, determine whether shiftwork impacts cardiovascular health, and develop drugs to heal cartilage. Long-term maintenance of the equipment will be managed by UAB’s Animal Resources Program and overseen by an external oversight board. Operation will be conducted by trained Animal Resources Program staff. In summary, the proposed bulk heat sterilizer will support the scientific needs of UAB’s large and growing research portfolio, offer substantial modernization of UAB’s equipment, and provide a green- technology solution consistent with UAB’s sustainability goals.

UAB的Zeigler建筑物中的散装干热灭菌器 UAB（阿拉巴马大学伯明翰大学）经历了快速的研究增长，目前排名全国NIH资助的排名前25名大学中。该提案要求资金购买散装热量灭菌器为位于UAB生物医学研究中心的Zeigler大楼中的Vivarium服务校园。为基于Zeigler Vivarium的71位动物研究人员服务，它将启用使用点灭菌和减轻污染的风险，以预先污染的笼子由卡车运输于不同的笼子校园大楼。该设备将为现代化，绿色和更严格的研究环境科学在UAB的第二大Vivarium Zeigler进行，以及无数的研究计划。希望在未来几十年中居住在齐格勒。 UAB使用3个集中式笼子清洗设施为12个校园内提供服务。该策略提供了有效的效率物流清洁和立体声大量脏笼子，但会影响科学严谨，因为立体声笼子是通过卡车从一座不同建筑物的笼子洗和蒸汽动力的高压灭菌设施中运输的回到齐格勒。购买这种灭菌器将减轻该运输的污染风险，现代化设施并满足可持续性目标。 Zeigler的Vivarium中发生的科学创新是广泛而令人印象深刻的。定量，该灭菌器将为来自17个学术部门的71名主要研究人员提供服务，其中58名由NIH资助在当前财政年度> 2800万美元的奖励。 Vivarium房屋约有4500个笼子，主要是小鼠和大鼠还包括雪貂，青蛙和龙猫。在体内发生的开创性科学的例子包括努力治疗肌肉营养不良，防止“化学obrain”，了解高果糖玉米糖浆对神经功能功能，检查对记忆的表观遗传作用，确定班次是否影响心血管健康，并开发药物以治愈软骨。该设备的长期维护将由UAB的动物资源计划和由外部监督委员会监督。操作将由受过训练的动物资源计划进行职员。总而言之，拟议的大量热灭菌剂将支持UAB大型和不断增长的研究组合，提供对UAB设备的实质性现代化，并提供绿色技术解决方案与UAB的可持续性目标一致。