Claude D Pepper Older Americans Independence Center at Yale

克劳德·D·佩珀 (Claude D Pepper) 耶鲁大学美国老年人独立中心

• 批准号: 7668586
• 负责人: MARY E TINETTI
• 金额: $ 116.89万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7668586
• 关键词: Claude; Pepper; Older; Americans; Independence

DESCRIPTION (provided by applicant): Established in 1992, the Yale Older Americans Independence Center (OAIC) seeks to continue providing intellectual leadership and innovation for aging research that aims to enhance independence. Our unifying theme remains the investigation of multifactorial geriatric health conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. Our premise is that health conditions common in older adults are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health domains. The predisposing factors may be at genetic, physiologic (impairment), disease, or socio-demographic levels, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. What distinguishes Yale OAIC research is that its purpose is to investigate the interactions among, or intervene on, multiple factors simultaneously and to measure the effect of conditions or interventions on a range of health domains. The Aims of the Yale OAIC are to: 1) develop the careers of future academic leaders in aging/geriatrics;2) train investigators and methodologists in the skills necessary to design, conduct, and analyze studies of multifactorial geriatric health conditions; 3) develop design and analytic techniques for conducting studies of multifactorial geriatric health conditions; 4) develop strategies for recruiting into, and retaining, a broad spectrum of older adults, including minorities, into OAIC studies; 5) investigate the causative mechanisms of, and identify effective treatments for, health conditions experienced by older adults from a multifactorial research perspective; 6) develop outcome measures for use in investigating multifactorial geriatric health conditions and for studying older adults with multiple coexisting conditions; and 7) facilitate basic, translational, and interdisciplinary research that connects to our focus on multifactorial geriatric health conditions. The Yale OAIC cores include: 1) Leadership / Administrative; 2) Research Career Development; 3) Pilot/Exploratory; 5) Biostatistics; 6) Data Management / Informatics; and 7) Field. For the first years of the next cycle, we propose to support 4 RCDC candidates; 4 pilot studies (including 2 by RCDC candidates); 1 computational biology development study; and 14 externally funded projects. PROGRAM AS A WHOLE

描述（由申请人提供）：成立于1992年，耶鲁大学年长的美国人独立中心（OAIC）试图继续为旨在增强独立性的衰老研究提供智力领导力和创新。我们的统一主题仍然是对多因素老年健康状况的研究，包括由多个因素或影响多个结果域和同时发生的多个条件产生的单一条件。我们的前提是，老年人常见的健康状况取决于多个诱发和降水因素的同时存在。这些条件和因素反过来影响了一系列健康领域。诱发因素可能是遗传，生理（损害），疾病或社会人口统计学水平，而降水因素可能是行为，环境，社会，医学或心理学。耶鲁大学的研究的区别在于，其目的是同时研究或干预多个因素之间的相互作用，并衡量条件或干预措施对一系列健康领域的影响。耶鲁大学的目的是：1）发展衰老/老年病的未来学术领导者的职业； 2）培训研究人员和方法学家在设计，进行和分析多因素老年医学健康状况的研究所需的技能； 3）开发设计和分析技术，用于进行多因素老年健康状况的研究； 4）制定招募并保留一系列老年人（包括少数民族）进入OAIC研究的策略； 5）研究老年人从多因素研究的角度研究老年人对健康状况的有效治疗的病因； 6）制定了用于研究多因素老年健康状况以及研究具有多种共存状况的老年人的结果指标； 7）促进基本，转化和跨学科研究，与我们关注多因素老年健康状况有关。耶鲁大学的核心包括：1）领导 /行政； 2）研究职业发展； 3）飞行员/探索性； 5）生物统计学； 6）数据管理 /信息学； 7）字段。在下一个周期的头几年中，我们建议支持4个RCDC候选人； 4个试点研究（包括2个由RCDC候选人）； 1计算生物学发展研究；和14个由外部资助的项目。 整个程序