The Impact of Maternal Depression, Anxiety, and Stress

母亲抑郁、焦虑和压力的影响

• 批准号: 7931868
• 负责人: SHERRYL H. GOODMAN
• 金额: $ 28.27万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7931868
• 关键词: Acute; Address; Affect; Alleles; Amylases; Antidepressive Agents; Anxiety; Area Under Curve; Auditory; Behavioral; Blood flow; Buffers; Cardiac; Caregivers; Caring; Center for Translational Science Activities; Child; Clinical; Complex; Data; Data Set; Development; Disease; Distress; Electroencephalography; Environment; Environmental Risk Factor; Exposure to; Fathers; Fetal Movement; Genes; Genetic Polymorphism; Genetic Risk; Genotype; Guidelines; Human; Husband; Hydrocortisone; Hyperactive behavior; Infant; Intervention; Left; Life; Link; Longitudinal Studies; Measures; Mediating; Mediation; Mediator of activation protein; Modeling; Mothers; Neonatal; Neurobiology; Neurosecretory Systems; Outcome; Parenting behavior; Participant; Pathway interactions; Pattern; Perinatal; Pharmaceutical Preparations; Postpartum Period; Predisposition; Pregnancy; Psychopathology; Psychophysiology; Relative (related person); Research; Risk; Risk Factors; Role; Salivary; Sampling; Serotonin; Severities; Speech; Stress; Subgroup; Testing; Time; Woman; Work; abstracting; base; depressed; depression; fetal; high risk; indexing; infant outcome; maternal depression; neonate; neurobehavioral; parent project; postnatal; prenatal; prenatal exposure; prospective; relating to nervous system; showing emotion; theories; transmission process; visual process; visual processing

PROJECT 3 - Abstract Important issues in the development of psychopathology will be addressed in a longitudinal study of infants exposed prenatally to their mothers' depression, stress, and anxiety. These women and their husbands/partners will be participants in the proposed translational research center, Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability. We have the unique opportunity to take advantage of the extensive prospective data that will have been collected throughout pregnancy, including measures of depression, stress, anxiety, use-of antidepressant medication (Core B), and fetal activity (Project 1) as well as genotyping for the 's' allele of the 5HT TLPR polymorphism in the infants and their parents (Project 2). In recognition of the unique aspects of the proposed dataset and the opportunities it presents for answering emerging questions, we propose to test hypotheses that promise to reveal the best model for understanding the most likely risk factors, mediators, and moderators in the transmission of risk for psychopathology in children born to women who were depressed during pregnancy. The Goodman and Gotlib (1999) model for the transmission of psychopathology to children of depressed mothers describes multiple mechanisms of risk whereby all of the infants in the proposed sample are at an increased risk for depression and other problems, relative to children whose mothers have not been depressed in pregnancy, and some are predicted to be at higher risk than others as a function of varying levels of genetic risk, adverse fetal environment, inadequate early maternal care, and father involvement. We propose to test hypotheses derived from this model in the prediction of the developmental course in the emergence (and continuity/discontinuity) of theory- and empirically-based measures of vulnerabilities for the development of psychopathology as they can be observed in infants. Assessments through the infants' first year will include measures of neuroendocrine, behavioral, and psychophysiological functioning. In order to take into consideration any added exposure to maternal depression, quality of maternal care, and the role fo the father, these constructs will also be measured. We will empirically derive the "best" set of predictors in a set of infant outcomes that have theoretical and empirical links implicating high risk for the later development of psychopathology. The understanding of such roles will be used to delineate guidelines for clinical interventions.

项目 3 - 摘要 精神病理学发展中的重要问题将在纵向研究中得到解决 婴儿在产前就暴露在母亲的抑郁、压力和焦虑之中。这些妇女和她们的 丈夫/伴侣将成为拟议的转化研究中心的参与者，围产期压力和 基因影响：婴儿脆弱性的途径。我们有独特的机会利用 将在整个怀孕期间收集广泛的前瞻性数据，包括 抑郁、压力、焦虑、抗抑郁药物的使用（核心 B）以及胎儿活动（项目 1） 作为婴儿及其父母 5HT TLPR 多态性的“s”等位基因的基因分型（项目 2）。在 认识到拟议数据集的独特之处及其提供的回答机会 对于新出现的问题，我们建议测试那些有望揭示最佳理解模型的假设 精神病理学风险传播中最可​​能的风险因素、中介因素和调节因素 怀孕期间患有抑郁症的妇女所生的孩子。 Goodman 和 Gotlib (1999) 模型 精神病理学向抑郁母亲的孩子的传播描述了多种风险机制 拟议样本中的所有婴儿患抑郁症和其他疾病的风险都会增加 与母亲在怀孕期间没有患抑郁症的孩子相关的问题，有些是 由于不同水平的遗传风险、不良胎儿的影响，预计比其他人面临更高的风险 环境、早期孕产妇护理不足以及父亲的参与。我们建议检验假设 从这个模型推导出来的发展过程的预测（和 连续性/不连续性）基于理论和经验的脆弱性衡量标准，以促进发展 可以在婴儿中观察到的精神病理学。婴儿第一年的评估将包括 神经内分泌、行为和心理生理功能的测量。为了考虑到 考虑任何增加的孕产妇抑郁风险、孕产妇护理质量以及孕产妇的作用 父亲，这些结构也将被测量。我们将凭经验得出一组中“最佳”的预测变量集 具有理论和经验联系的婴儿结局，暗示着以后发展的高风险 精神病理学。对这些角色的理解将用于描述临床指南 干预措施。