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• 批准号: 7441286
• 负责人: PETER RAYMOND MACLEISH
• 金额: $ 38.48万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7441286
• 关键词: Academy; Achievement; Administrator; Advisory Committees; Anatomy; Award; Brain Ischemia; Businesses; Chairperson; Circadian Rhythm Sleep Disorders; Circadian Rhythms; Clinical; Development; Equipment and Supplies; Faculty; Grant; Home environment; Institute of Medicine (U.S.); Institutes; International; Leadership; Medical; Memorial Sloan-Kettering Cancer Center; Names; Neuregulins; Neurobiology; Neurosciences; Neurosciences Research; Occupations; Ophthalmology; Physiology; Policies; Principal Investigator; Range; Recording of previous events; Reporting; Research; Research Institute; Research Personnel; Role; Specialized Center; Stroke; Study Section; Training; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Vision; Vision research; Work; college; experience; farmer; medical schools; member; nervous system disorder; neuroprotection; professor; programs; skills; symposium

In this new application, the Morehouse School of Medicine Neuroscience Institute is requesting funds to consolidate a program in Circadian Rhythms and Sleep Disorders (CRSD) that was established within the last two years. The CRSD Program is headed by Dr. Gianluca Tosini, an established investigator in the field of circadian rhythms. The current proposal consists of projects from 2 recently-recruited young investigators (Drs. Davidson and Paul) and 1 previously-funded investigator (Dr. Fukuhara). All projects build on the impressive advances of our understanding of the molecular components of the master circadian pacemaker and the interrelationships with peripheral circadian oscillators. All three projects have strong translational components and have direct relevance to a number of disorders that disproportionately affect minority populations. Dr. Davidson's research program (Project # 1) will investigate the consequence of changing lighting schedules (as might occur as a result of shift-work and jet-lag) on the health of mice. Dr. Fukuhara's research program (Project # 2) is centered on the relationships between mood disorders and misalignment of circadian rhythms. Dr. Paul's research program (Project # 3) will investigate sleep in a series of genetically altered mice. Another program -The Neuroprotection, Neurorepair and Stroke Program - headed by Dr. Byron Ford, has 2 R01 holders, is not requesting funds, but will make intellectual contributions towards the maintenance of a vibrant research environment within the Neuroscience Institute. In addition to requesting funds for the three projects listed above, the proposal requests funds for an administrative core and two research cores - Cell and Molecular Biology Core and Imaging and Microscopy Core - that will, in a cost-effective manner, support the science within the projects. Finally, a Training and Knowledge Transfer Core is requesting funds to continue a highly-successful Summer Research Program for undergraduates and medical students and a seminar series to keep investigators abreast of research from leading investigators. Our goal is to increase the number of investigators at MSM who are conducting competitive research at the R01 level and the pool of students from under-represented populations who are pursuing a career in the field of Neuroscience.

在这个新应用中，莫尔豪斯医学院神经科学学院正在要求资金 合并一个昼夜节律和睡眠障碍（CRSD）的程序 最近两年。 CRSD计划由该领域成熟的研究员Gianluca Tosini博士领导 昼夜节律。当前的提案包括来自最近聘用的2名年轻调查人员的项目 （Davidson和Paul博士）和1名先前资助的调查员（Fukuhara博士）。所有项目都建立在 我们对大师昼夜节奏起搏器分子成分的理解的令人印象深刻的进步 以及与外围昼夜节律振荡器的相互关系。这三个项目都有很强的翻译 组成部分，与多种影响少数群体的疾病有直接相关性 人群。戴维森博士的研究计划（项目＃1）将调查改变的后果 照明时间表（由于轮班工作和喷射滞后可能导致的小鼠健康）。福哈拉博士 研究计划（项目＃2）以情绪障碍与未对准之间的关系为中心 昼夜节律。保罗博士​​的研究计划（项目＃3）将研究一系列的睡眠 遗传改变的小鼠。另一个程序 - 神经保护，神经台和中风程序 - 领导 拜伦·福特（Byron Ford）博士拥有2个R01持有人，不是要求资金 旨在维护神经科学研究所内的充满活力的研究环境。 除了要求上述三个项目的资金外，该提案还要求资金 行政核心和两个研究核心 - 细胞和分子生物学核心以及成像和显微镜 核心 - 这将以具有成本效益的方式支持项目中的科学。最后，培训和 知识转移核心要求资金继续一项非常成功的夏季研究计划 本科生和医学生以及一个研讨会系列，以使调查人员并肩研究 领先的调查员。 我们的目标是增加MSM的调查人员的数量，他们正在进行竞争性研究 R01级别和来自代表性不足的人群的学生库从事该领域的职业 神经科学。