Basic & Translational Neuroscience Research

基本的

• 批准号: 8148134
• 负责人: PETER RAYMOND MACLEISH
• 金额: $ 10万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8148134
• 关键词: Affect; Cells; Circadian Rhythm Sleep Disorders; Circadian Rhythms; Disease; Environment; Funding; Goals; Head; Health; Image; Institutes; Jet Lag Syndrome; Knowledge; Lighting; Maintenance; Medical Students; Microscopy; Minority; Molecular; Molecular Biology; Mood Disorders; Mus; Neurosciences; Neurosciences Research; Peripheral; Population; Program Research Project Grants; Recruitment Activity; Request for Proposals; Research; Research Personnel; Schedule; Science; Series; Sleep; Stroke; Students; Training; career; circadian pacemaker; cost effective; medical schools; neuroprotection; programs; shift work; translational neuroscience

DESCRIPTION (provided by applicant): In this new application, the Morehouse School of Medicine Neuroscience Institute is requesting funds to consolidate a program in Circadian Rhythms and Sleep Disorders (CRSD) that was established within the last two years. The CRSD Program is headed by Dr. Gianluca Tosini, an established investigator in the field of circadian rhythms. The current proposal consists of projects from 2 recently-recruited young investigators (Drs. Davidson and Paul) and 1 previously-funded investigator (Dr. Fukuhara). All projects build on the impressive advances of our understanding of the molecular components of the master circadian pacemaker and the interrelationships with peripheral circadian oscillators. All three projects have strong translational components and have direct relevance to a number of disorders that disproportionately affect minority populations. Dr. Davidson's research program (Project # 1) will investigate the consequence of changing lighting schedules (as might occur as a result of shift-work and jet-lag) on the health of mice. Dr. Fukuhara's research program (Project # 2) is centered on the relationships between mood disorders and misalignment of circadian rhythms. Dr. Paul's research program (Project # 3) will investigate sleep in a series of genetically altered mice. Another program -The Neuroprotection, Neurorepair and Stroke Program - headed by Dr. Byron Ford, has 2 R01 holders, is not requesting funds, but will make intellectual contributions towards the maintenance of a vibrant research environment within the Neuroscience Institute. In addition to requesting funds for the three projects listed above, the proposal requests funds for an administrative core and two research cores - Cell and Molecular Biology Core and Imaging and Microscopy Core - that will, in a cost-effective manner, support the science within the projects. Finally, a Training and Knowledge Transfer Core is requesting funds to continue a highly-successful Summer Research Program for undergraduates and medical students and a seminar series to keep investigators abreast of research from leading investigators. Our goal is to increase the number of investigators at MSM who are conducting competitive research at the R01 level and the pool of students from under-represented populations who are pursuing a career in the field of Neuroscience.

描述（由申请人提供）： 在这一新应用中，莫尔豪斯医学学院神经科学学院正在要求资金巩固在过去两年内建立的昼夜节律和睡眠障碍（CRSD）的计划。 CRSD计划由昼夜节律领域的既定研究者Gianluca Tosini博士领导。当前的提案包括来自最近聘用的年轻调查员（Davidson和Paul博士）和1名先前资助的研究人员（Fukuhara博士）的项目。所有项目都以我们对昼夜节律起搏器大师分子成分以及与外围昼夜节律振荡器的相互关系的理解的令人印象深刻的进步为基础。这三个项目都具有强大的翻译组成部分，并且与多种影响少数群体的多种疾病具有直接相关性。戴维森博士的研究计划（项目＃1）将调查改变小鼠健康的照明时间表（由于轮班工作和喷气工作的结果）的结果。 Fukuhara博士的研究计划（项目＃2）集中在情绪障碍与昼夜节律未对准之间的关系。保罗博士​​的研究计划（项目＃3）将研究一系列遗传改变的小鼠的睡眠。由拜伦·福特（Byron Ford）博士领导的另一个计划 - 神经保护，神经卫星和中风计划，有2个R01持有人，不是要求资金，而是为维持神经科学研究所内充满活力的研究环境做出智力贡献。除了要求上述三个项目的资金外，该提案还向行政核心和两个研究核心要求资金 - 细胞和分子生物学核心以及成像和显微镜核心 - 将以具有成本效益的方式支持项目中的科学。最后，培训和知识转移核心是要求资金继续为本科生和医学生的高度成功的夏季研究计划，以及一个研讨会系列，以使研究人员与领先的研究人员的研究保持一致。 我们的目标是增加在R01级进行竞争性研究的MSM的调查人员数量，以及来自代表性不足的人群的学生群，这些人从事神经科学领域的职业。