Morehouse School of Medicine SNRP

莫尔豪斯医学院 SNRP

• 批准号: 8574241
• 负责人: PETER RAYMOND MACLEISH
• 金额: $ 139.51万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8574241
• 关键词: Acids; Animal Model; Basic Science; Betaine; Chromosome Mapping; Combined Modality Therapy; Critiques; Deterioration; Development; Disease; Effectiveness; Environment; Faculty; Fenofibrate; Genetic; Goals; Individual; Institutes; Institution; Ions; Leadership; Mediating; Medical; Mission; Morehouse School of Medicine; National Institute of Neurological Disorders and Stroke; Neurons; Neurosciences; Neurosciences Research; Outcome; Phenotype; Physiological; Population; Postdoctoral Fellow; Readiness; Regulator Genes; Research; Research Training; Resources; Role; Services; Signal Pathway; Signal Transduction; Sleep; Sleep Disorders; Strategic Planning; Students; Subarachnoid Hemorrhage; Testing; Training; Translational Research; burden of illness; career; comparative; graduate student; nervous system disorder; novel; programs; public health relevance; tool

DESCRIPTION (provided by applicant): Morehouse School of Medicine (MSM) is a young and dynamic institution with a strong mission of service to the underserved through the training of medical and scientific professionals and through the focused development of a basic and translational research environment dedicated to exploring mechanisms of disorders with high disease burden in populations served by the institution. In keeping with the intent of the RFA and consistent with its internal strategic plan, the MSM Neuroscience Institute proposes to augment and strengthen its research programs focused on NINDS mission related research and to increase the academic preparedness of students from diverse backgrounds for advanced Neuroscience research careers. In this application, we proposed three exploratory projects that focus on: (1) Identifying new genetic targets to help treat sleep disorders (Project 1, Pi's Paul and DeBruyne). In this project, the Pi's will combine a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory gene; (ii) Understanding the role of Acid Sensing Ion Chanel 1a (ASICIa) -mediated signaling pathways in neurons (Project 2, PI Xiong). In this proposal, the PI will define ASICIa-mediated signaling cascades in physiological- and pathophysiological conditions; and (iii) The effectiveness of a combination therapy against delayed neuronal deterioration after subarachnoid hemorrhage (Project 3, PI Namura). This project will test the hypothesis that the combination of betaine (trimethylglycine) and fenofibrate may be a potential strategy for treating this neurological disease. Two other objectives of the application are (i) to train and develop a competitive cadre of neuroscientists from underrepresented groups by providing tools to enhance the competiveness of Neuroscience Institute faculty; and (11) to provide training opportunities for graduate students and postdoctoral fellows and to expand the pool of undergraduates exposed to competitive Neuroscience research. To accomplish the above goals, we will provide effective administrative and scientific resource cores to facilitate the goals of this application.

描述（由申请人提供）：莫尔豪斯医学院 (MSM) 是一所年轻而充满活力的机构，其强烈的使命是通过培训医疗和科学专业人员以及通过重点发展专门的基础和转化研究环境来为服务不足的人群提供服务。探索该机构服务的人群中疾病负担高的疾病机制。为了符合 RFA 的意图并与其内部战略计划保持一致，MSM 神经科学研究所建议扩大和加强其以 NINDS 任务相关研究为重点的研究项目，并提高来自不同背景的学生为高级神经科学研究职业做好学术准备。在此申请中，我们提出了三个探索性项目，重点关注：(1) 识别新的遗传靶点以帮助治疗睡眠障碍（项目 1，Pi 的 Paul 和 DeBruyne）。在这个项目中，Pi's 将把基因上易于处理的动物模型的比较表型的完善范例与强大的基因作图工具结合起来，以识别新的睡眠调节基因； (ii) 了解酸敏感离子通道 1a (ASICIa) 介导的神经元信号通路的作用（项目 2，PI Xiong）。在该提案中，PI 将定义生理和病理生理条件下 ASICIa 介导的信号级联； (iii) 联合疗法对抗蛛网膜下腔出血后迟发性神经元恶化的有效性（项目 3，PI Namura）。该项目将测试甜菜碱（三甲基甘氨酸）和非诺贝特的组合可能是治疗这种神经系统疾病的潜在策略的假设。该应用程序的另外两个目标是 (i) 通过提供增强神经科学研究所教师竞争力的工具，培训和培养来自代表性不足群体的有竞争力的神经科学家骨干队伍； (11)为研究生和博士后提供培训机会，并扩大接触竞争性神经科学研究的本科生人数。为了实现上述目标，我们将提供有效的行政和科学资源核心，以促进该应用程序的目标的实现。