Morehouse School of Medicine SNRP

莫尔豪斯医学院 SNRP

• 批准号: 8574241
• 负责人: PETER RAYMOND MACLEISH
• 金额: $ 139.51万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8574241
• 关键词: Acids; Animal Model; Basic Science; Betaine; Chromosome Mapping; Combined Modality Therapy; Critiques; Deterioration; Development; Disease; Effectiveness; Environment; Faculty; Fenofibrate; Genetic; Goals; Individual; Institutes; Institution; Ions; Leadership; Mediating; Medical; Mission; Morehouse School of Medicine; National Institute of Neurological Disorders and Stroke; Neurons; Neurosciences; Neurosciences Research; Outcome; Phenotype; Physiological; Population; Postdoctoral Fellow; Readiness; Regulator Genes; Research; Research Training; Resources; Role; Services; Signal Pathway; Signal Transduction; Sleep; Sleep Disorders; Strategic Planning; Students; Subarachnoid Hemorrhage; Testing; Training; Translational Research; burden of illness; career; comparative; graduate student; nervous system disorder; novel; programs; public health relevance; tool

DESCRIPTION (provided by applicant): Morehouse School of Medicine (MSM) is a young and dynamic institution with a strong mission of service to the underserved through the training of medical and scientific professionals and through the focused development of a basic and translational research environment dedicated to exploring mechanisms of disorders with high disease burden in populations served by the institution. In keeping with the intent of the RFA and consistent with its internal strategic plan, the MSM Neuroscience Institute proposes to augment and strengthen its research programs focused on NINDS mission related research and to increase the academic preparedness of students from diverse backgrounds for advanced Neuroscience research careers. In this application, we proposed three exploratory projects that focus on: (1) Identifying new genetic targets to help treat sleep disorders (Project 1, Pi's Paul and DeBruyne). In this project, the Pi's will combine a well-established paradigm of comparative phenotyping of a genetically tractable animal model with powerful genetic mapping tools to identify novel sleep-regulatory gene; (ii) Understanding the role of Acid Sensing Ion Chanel 1a (ASICIa) -mediated signaling pathways in neurons (Project 2, PI Xiong). In this proposal, the PI will define ASICIa-mediated signaling cascades in physiological- and pathophysiological conditions; and (iii) The effectiveness of a combination therapy against delayed neuronal deterioration after subarachnoid hemorrhage (Project 3, PI Namura). This project will test the hypothesis that the combination of betaine (trimethylglycine) and fenofibrate may be a potential strategy for treating this neurological disease. Two other objectives of the application are (i) to train and develop a competitive cadre of neuroscientists from underrepresented groups by providing tools to enhance the competiveness of Neuroscience Institute faculty; and (11) to provide training opportunities for graduate students and postdoctoral fellows and to expand the pool of undergraduates exposed to competitive Neuroscience research. To accomplish the above goals, we will provide effective administrative and scientific resource cores to facilitate the goals of this application.

描述（由申请人提供）：Morehouse医学院（MSM）是一个年轻而充满活力的机构，通过培训医学和科学专业人员的培训以及针对基本和转化的研究环境的重点发展，致力于探索该机构为疾病负担高的疾病负担的疾病机制，以实现服务不足的任务。为了符合RFA的意图并符合其内部战略计划，MSM神经科学研究所建议增强和加强其研究计划，重点关注NINDS与Mission相关的研究，并提高来自高级神经科学研究的不同背景的学生的学术准备。在此应用程序中，我们提出了三个探索性项目，重点介绍：（1）确定新的遗传靶标以帮助治疗睡眠障碍（项目1，PI的Paul和Debruyne）。在这个项目中，PI将结合一个遗传上可牵引动物模型的比较表型的范式，并结合强大的遗传学映射工具，以识别新型的睡眠调节基因。 （ii）了解神经元中酸感应离子香奈儿1A（ASICIA）介导的信号通路的作用（Project 2，Pi Xiong）。在此提案中，PI将在生理和病理生理条件下定义ASICIA介导的信号级联。 （iii）组合疗法对亚蛛网膜下腔出血后延迟神经元恶化的有效性（Project 3，Pi Namura）。该项目将检验以下假设，即甜菜碱（三甲基甘氨酸）和非诺贝特的结合可能是治疗这种神经系统疾病的潜在策略。应用程序的其他两个目标是（i） 通过提供工具来增强神经科学学院教职员工的竞争力，培训并发展了来自代表性群体不足的群体的神经科学家的竞争性干部； （11）为研究生和博士后研究员提供培训机会，并扩大暴露于竞争性神经科学研究的本科生。为了实现上述目标，我们将提供有效的行政和科学资源核心，以促进该应用程序的目标。