Noninvasive Cardiovascular Imaging Research Training Program

无创心血管影像研究培训计划

• 批准号: 10641765
• 负责人: Marcelo F DI CARLI
• 金额: $ 57.47万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10641765
• 关键词: Research Training; Training Programs; cardiovascular imaging

Cardiovascular (CV) disease is the leading cause of morbidity and mortality in the US and worldwide. Non-invasive imaging provides valuable information to assess differential diagnosis and guide management. However, there is a gap in academically-oriented CV imaging training programs that are able to train specialists with the knowledge base, experience, research tools, analytical and leadership skills to fully develop, apply, and evaluate the increasingly complex gamut of CV imaging possibilities. This is the second competing renewal application for this T32 program. This program offers post-doctoral research training for individuals with an MD, or combined MD/PhD degrees, who have completed clinical training in cardiology, radiology, or CV imaging who are committed to pursuing an academic career in CV imaging science. Our goal is to continue to provide outstanding opportunities for multi- disciplinary research training for clinician-scientists in CV imaging with the clinical and investigative skills to establish independent careers, mentor others, and lead their own programs. Since initial funding in 2010, we have graduated 16 post-doctoral fellows. Key indicators of the effectiveness of this young program include: (1) 15/16 graduates remain involved in academic medicine and science, and one is completing additional clinical training; (2) 8/10 fellows who completed the program 2 years ago have received peer reviewed funding by NIH, VA, or ACC. Of the 6 graduates from the last 2 years, one received an ACC mentored award, one received grant funding from the Radiological Society of North America, and one just submitted a K award; (3) the grant has sponsored 133 unique publications in top peer review journals; (4) 50% of our graduates hold leadership roles in their respective imaging programs, and 38% have prominent leadership roles in professional organizations and others. Our mentors are primarily comprised of cardiologists and radiologists, but also include faculty from disciplines outside CV imaging including clinical and basic scientists. All the mentors have a strong track record of research collaborations. We offer research training opportunities in 8 thematic areas: (1) molecular imaging, (2) myocardial structure, function, and metabolism, (3) genetics, (4) pulmonary hypertension, (5) outcomes research, (6) ischemic heart disease, (7) women's health, (8) radiomics and artificial intelligence. The proposed program supports 3 positions/year for two years of continued research training. With this renewal, we continue our primary goals of providing leadership in academic cardiovascular imaging and training future leaders in imaging science to improve outcomes in cardiovascular disease.

心血管 (CV) 疾病是美国发病率和死亡率的主要原因 在全球范围内，非侵入性成像为评估差异提供了宝贵的信息。 然而，以学术为导向的简历存在差距。 能够利用知识库培训专家的成像培训计划， 充分开发、应用和评估的经验、研究工具、分析和领导技能 CV 成像的可能性日益复杂，这是第二个竞争点。 T32项目的续签申请该项目为博士后研究培训。 拥有医学博士学位或医学博士学位/博士学位，并完成了临床培训的个人 致力于在 CV 领域从事学术职业的心脏病学、放射学或 CV 成像 我们的目标是继续为多学科提供卓越的机会。 为临床医生和科学家提供 CV 成像与临床和应用领域的学科研究培训 建立独立职业、指导他人并领导自己的调查技能 自2010年首次资助以来，我们已经毕业了16名关键博士后。 这一年轻计划的有效性指标包括：(1) 15/16 名毕业生留任 参与学术医学和科学，其中一名正在完成额外的临床培训； (2) 8/10 两年前完成该项目的研究员获得了同行评审资助 在过去 2 年的 6 名毕业生中，有 1 名获得了 ACC 指导。 奖，一位获得了北美放射学会的资助，一位刚刚获得 提交了K奖；（3）该资助资助了133篇在顶级同行评审中的独特出版物 (4) 50% 的毕业生在各自的成像项目中担任领导职务， 38% 在专业组织和其他组织中担任重要的领导职务。 导师主要由心脏病专家和放射科医生组成，但也包括来自 CV 成像以外的学科，包括临床和基础科学家。 我们在 8 个领域提供研究培训机会。 专题领域：(1) 分子成像，(2) 心肌结构、功能和代谢，(3) 遗传学，(4) 肺动脉高压，(5) 结果研究，(6) 缺血性心脏病，(7) 妇女健康，(8) 放射组学和人工智能 拟议计划支持 3。 每年职位，为期两年的持续研究培训。通过这次更新，我们将继续我们的研究。 主要目标是在学术心血管成像和未来培训方面发挥领导作用 成像科学领域的领导者，致力于改善心血管疾病的治疗结果。

项目成果

Preventive Management of Nonobstructive CAD After Coronary CT Angiography in the Emergency Department.

急诊科冠状动脉 CT 血管造影后非阻塞性 CAD 的预防性管理。

• DOI: 10.1016/j.jcmg.2019.04.021
• 发表时间: 2020-02-01
• 期刊: JACC. Cardiovascular imaging
• 作者: M. Honigberg;Bradley S. L;er;er;V. Baliyan;Maeve Jones;Emma W. Healy;J. Scholtz;J. Nagurney;U. Hoffmann;B. Ghoshhajra;P. Natarajan
• 通讯作者: P. Natarajan

Sex Differences in Clinical Characteristics and Outcomes After Myocardial Infarction With Low Ejection Fraction: Insights From PARADISE-MI.

低射血分数心肌梗死后临床特征和结果的性别差异：来自 PARADISE-MI 的见解。

• 发表时间: 2023-09-05
• 影响因子: 5.4
• 作者: Wang, Xiaowen;Jering, Karola S;Cikes, Maja;Tokmakova, Mariya P;Mehran, Roxana;Han, Yaling;East, Cara;Mody, Freny Vaghaiwalla;Wang, Yi;Lewis, Eldrin F;Claggett, Brian;McMurray, John J V;Granger, Christopher B;Pfeffer, Marc A;Solomon, Scott D
• 通讯作者: Solomon, Scott D

The effect of emphysema on readmission and survival among smokers with heart failure.

肺气肿对患有心力衰竭的吸烟者的再入院和生存的影响。

• 发表时间: 2018
• 影响因子: 3.7
• 作者: Kohli, Puja;Staziaki, Pedro V;Janjua, Sumbal A;Addison, Daniel A;Hallett, Travis R;Hennessy, Orla;Takx, Richard A P;Lu, Michael T;Fintelmann, Florian J;Semigran, Marc;Harris, Robert S;Celli, Bartolome R;Hoffmann, Udo;Neilan, Tomas G
• 通讯作者: Neilan, Tomas G

When Can We Defer Testing for Patients With Stable Chest Pain?

我们什么时候可以推迟对稳定胸痛患者的检测？

• 发表时间: 2018
• 作者: Blankstein, Ron;Divakaran, Sanjay;Shaw, Leslee
• 通讯作者: Shaw, Leslee

Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk.

SGLT1、葡萄糖耐量和心脏代谢风险的遗传变异。

• 发表时间: 2018-10-09
• 影响因子: 24
• 作者: Seidelmann, Sara B;Feofanova, Elena;Yu, Bing;Franceschini, Nora;Claggett, Brian;Kuokkanen, Mikko;Puolijoki, Hannu;Ebeling, Tapani;Perola, Markus;Salomaa, Veikko;Shah, Amil;Coresh, Josef;Selvin, Elizabeth;MacRae, Calum A;Cheng, Susan;Boerwin
• 通讯作者: Boerwin