Neural and Perceptual Correlates of Expectation

期望的神经和感知相关性

• 批准号: 7547759
• 负责人: Vinod Rao
• 金额: $ 4.79万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7547759
• 关键词: Area; Attention; Behavior; Behavioral; Behavioral Paradigm; Body Dysmorphic Disorder; Brain; Cognition Disorders; Cues; Data; Discrimination; Dorsal; Electrophysiology (science); Environment; Face; Individual; Location; Monkeys; Motion; Neurons; Obsessive-Compulsive Disorder; Organ; Patients; Perception; Performance; Placebo Effect; Primates; Probability; Psychophysiology; Relative (related person); Sensory; Sensory Process; Signal Transduction; Stimulus; Stream; Testing; Training; Visual; base; digital imaging; expectation; improved; physical process; relating to nervous system; research study; response; visual process; visual processing; visual stimulus

DESCRIPTION (provided by applicant): Certain cognitive disorders manifest as distorted perception of the physical world. For example, studies have indicated that patients with body dysmorphic disorder or obsessive-compulsive disorder are more likely to modify a digital image of their face to match their own expectation of what their face looks like. The proposed study aims to understand the neural basis for such expectation effects, based on a hypothesis of how expectation signals modify processing of physical stimuli. By combining a perceptual task where a cue biases the behavior with single-unit electrophysiology in primates, expectation effects on the neural representation of external stimuli will be sought. In particular, one possible mechanism for expectation- related behavioral changes predicts that an expectation signal increases neural sensitivity and improves the ability to predict behavioral performance from the neural response. These studies will help reveal how expectation-induced changes in sensory representation might underlie perceptual discrepancies in certain cognitive disorders.

描述（由申请人提供）：某些认知障碍表现为对物理世界的扭曲感。例如，研究表明，身体畸形障碍或强迫症的患者更有可能改变面部的数字形象，以符合他们对脸部外观的期望。拟议的研究旨在基于对期望信号如何修改物理刺激的处理的假设来理解这种期望效应的神经基础。通过将提示偏向于灵长类动物中的单单电生理学偏向行为的感知任务，将寻求对外部刺激神经表示的期望影响。特别是，与期望相关的行为变化的一种可能机制预测，期望信号会提高神经敏感性，并提高从神经反应中预测行为性能的能力。这些研究将有助于揭示期望诱发的感觉表示变化如何在某些认知障碍中具有感知差异的基础。

项目成果

The road least taken.

最少走的路。

• DOI: 10.1038/nn0608-623
• 发表时间: 2008
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Rao,Vinod;Snyder,LawrenceH
• 通讯作者: Snyder,LawrenceH