Functional Neuroimaging of Strategic Retrieval Processes

策略检索过程的功能神经影像

• 批准号: 7647887
• 负责人: Ian G Dobbins
• 金额: $ 21.14万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7647887
• 关键词: Adopted; Agreement; Alzheimer' s Disease; Binding; Characteristics; Classification; Cognition; Cognitive; Cues; Data; Decision Modeling; Decision Theory; Dementia; Dependency; Detection; Divorce; Dorsal; Drug Formulations; Episodic memory; Equilibrium; Evaluation; Familiarity; Frequencies; Functional Imaging; Functional Magnetic Resonance Imaging; Generations; Judgment; Left; Link; Location; Maps; Memory; Modeling; Monitor; Nature; Neurologic; Operative Surgical Procedures; Performance; Play; Population; Prefrontal Cortex; Process; Recovery; Regulation; Relative (related person); Research; Research Personnel; Resolution; Retrieval; Role; Signal Transduction; Source; Specificity; System; Targeted Research; Testing; Translations; Traumatic Brain Injury; Weight; base; behavioral impairment; blood oxygenation level dependent response; executive function; experience; healthy aging; memory retrieval; mild neurocognitive impairment; nervous system disorder; neuroimaging; patient population; programs; relating to nervous system; response; success

DESCRIPTION (provided by applicant): Episodic remembering critically relies on the generation retrieval plans, the elaborative processing of retrieval probes, the resolution of interference, and the monitoring of the sufficiency of memory with respect to decision criteria. Although prefrontal cortex (PFC) is the favored candidate for these mechanisms, regional and hemispheric localization for these mechanisms is unclear. Using a component-process model we will: (1) Determine whether left PFC is critically involved in formulating episodic retrieval plans. Recent research contrasting context and item memory have consistently identified left PFC and indicated that activity is not dependent on success, suggesting that it is the intent to retrieve contextual information that is critical. Here we intend to separate cue/question and probe dependent activity and determine whether these regions respond to non-verbalizable probes during contextually based retrieval demands. (2) Conduct Decision Theory based manipulations of memory decision criteria. By manipulating the number, location, and quality of decision criteria we will isolate PFC regions critical for implementing decision rules to memory content. (3) Investigate hemispheric asymmetries during episodic retrieval. Recent evidence suggests hemispheric asymmetries in PFC (particularly dorsal and polar) with left regions associated with contextually specific source attribution, and homologous right PFC regions showing relative increases during judgments of item recency or frequency, which are potentially based on global familiarity assessment. By directly contrasting recency, frequency, and context retrieval for matched materials within subjects, we will test whether the hemispheres are involved in fundamentally different aspects of memory retrieval, advancing beyond earlier constructs such as "effort" or "difficulty". Neurological changes during healthy aging and neurological disorders (e.g., Alzheimer's Dementia, Mild Cognitive Impairment, Traumatic Brain Injury) severely impact memory performance. However, because the control or decision processes regulating memory expression are poorly understood, behavioral impairments could often result from damage to systems that represent or store memory evidence, systems responsible for imposing decisions upon that content, or some combination of the 2. Determining how PFC regions normally regulate the translation of memory content into decisions or actions is therefore critical in understanding the memory performance decline in the above populations.

描述（由申请人提供）：情节记忆非常依赖于生成检索计划，检索探针的精心处理，干扰解决方案以及对决策标准的记忆充分性的监视。尽管前额叶皮层（PFC）是这些机制的最受欢迎的候选者，但这些机制的区域和半球定位尚不清楚。使用组件过程模型，我们将：（1）确定左PFC是否与制定情节检索计划有关。最近的研究对比上下文和项目存储器一直确定左PFC，并表明活动不取决于成功，这表明其目的是检索至关重要的上下文信息。在这里，我们打算将提示/问题和探测依赖性活动分开，并确定这些区域在基于上下文的检索需求期间是否响应了不可言喻的探针。 （2）基于记忆决策标准的基于决策理论的操纵。通过操纵决策标准的数量，位置和质量，我们将隔离PFC区域对于将决策规则实施到内存内容至关重要。 （3）研究情节检索期间的半球不对称。最近的证据表明，PFC（尤其是背侧和极性）的半球不对称，左侧区域与上下文特定的源归因相关，同源的右PFC区域显示，在项目新近度或频率判断过程中相对增加，这可能基于全球熟悉度评估。通过直接对比对受试者中匹配材料的新近度，频率和上下文检索，我们将测试半球是否参与记忆检索的根本不同方面，超越了早期的结构，例如“努力”或“困难”。健康衰老和神经系统疾病期间的神经系统变化（例如，阿尔茨海默氏症的痴呆症，轻度认知障碍，脑外伤性脑损伤）严重影响记忆表现。但是，由于调节记忆表达的控制或决策过程的理解很少，因此行为障碍通常可能是由于对代表或存储记忆证据的系统的损坏，负责对该内容强加决策的系统或2的某些组合的系统。确定PFC区域通常如何调节记忆内容或行动如何在上述群体中转化为决策或行动是重要的。