Interdisciplinary malaria research training in Malawi

马拉维跨学科疟疾研究培训

• 批准号: 10453101
• 负责人: Miriam K. Laufer
• 金额: $ 5.32万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-10 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10453101
• 关键词: Address; Area; Biology; Biometry; Collaborations; Doctor of Philosophy; Epidemiologist; Faculty; Future; Health; Infectious Diseases Research; Institution; International; Laboratories; Life; Malaria; Malawi; Maryland; Medicine; Mentors; Mentorship; Michigan; Molecular; Molecular Epidemiology; Prevention; Research; Research Methodology; Research Personnel; Research Training; Risk; Rotation; Supervision; Training; Training Programs; Universities; college; design; didactic education; effective intervention; experience; innovation; insight; member; programs; senior faculty; skills; success; synergism; transmission process; vector

PROJECT SUMMARY Malaria continues to be one of the greatest threats to health and life in Malawi, and recent control efforts have yielded only moderate success. New insights into what determines risk and how to design more effective interventions are imperative to enhance control and ultimately eliminate malaria in the region. This Global Infectious Diseases Research Training Program is established on the basis of long-standing and productive collaborations between senior faculty members at the University of Malawi College of Medicine and a core team of international investigators who have been engaged in malaria research in Malawi for decades. The training program was crafted to train the experts required to develop independent research teams in Malawi capable of designing, leading and analyzing results of locally and internationally relevant studies, and to create a robust and sustainable graduate program in Malawian universities. Careful selection and training of a molecular epidemiologist, a vector biologist and two biostatisticians will prepare leaders in the health research agenda, focused on hypothesis-driven scientific questions. We will also provide formal short course training in specific research methods and tailor opportunities for laboratory rotations to provide succession planning to create a pipeline of future PhD candidates and the junior faculty members who support them. Through the direct supervision, guidance and mentorship of the training team members, these trainees will benefit from outstanding didactic educations and also from the hands-on mentoring provided by experienced colleagues and recent graduates who are now faculty members in Malawi. This interdisciplinary training program is designed achieve the following specific aims: (1) Train successful investigators in molecular epidemiology, vector biology and biostatistics, (2) Establish core faculty for a rigorous, independent PhD program in Malawi, and (3) Support succession planning for future PhD trainees and mentors within Malawi. The specific areas of training were identified as essential to on-going and future health research in Malawi, reflect strengths of the collaborating institutions (University of Maryland, Michigan State University and University of the Witwatersrand), and create synergies with emerging opportunities within the University of Malawi. Cross- cutting, innovative, well-executed and expertly analyzed studies will address specific challenges of malaria treatment, prevention, and transmission reduction. In addition, the skill sets developed by all the trainees in this proposed effort will be applicable to a wide range of infectious as well as non-communicable diseases.

项目概要 疟疾仍然是马拉维健康和生命面临的最大威胁之一，最近的控制工作已取得进展 只取得了一定的成功。关于风险决定因素以及如何设计更有效的新见解 为了加强控制并最终消除该地区的疟疾，必须采取干预措施。这个全球 传染病研究培训项目是在长期有效的基础上建立的 马拉维大学医学院高级教员与核心人员之间的合作 由数十年来在马拉维从事疟疾研究的国际研究人员组成的团队。这 制定培训计划是为了培训在马拉维建立独立研究团队所需的专家 能够设计、领导和分析本地和国际相关研究的结果，并创造 马拉维大学强大且可持续的研究生项目。精心挑选和培训 分子流行病学家、媒介生物学家和两名生物统计学家将培养健康研究领域的领导者 议程，重点关注假设驱动的科学问题。我们还将提供正式的短期课程培训 具体的研究方法并定制实验室轮换的机会，以提供继任计划 建立未来博士候选人和支持他们的初级教员的渠道。通过 培训团队成员的直接监督、指导和辅导，这些学员将受益于 出色的教学教育以及经验丰富的同事提供的实践指导 以及目前在马拉维任教的应届毕业生。这个跨学科的培训计划是 旨在实现以下具体目标：（1）培训成功的分子流行病学研究人员， 矢量生物学和生物统计学，(2) 在马拉维建立严格、独立的博士课程的核心师资队伍， (3) 支持马拉维未来博士生和导师的继任计划。具体领域为 培训被认为对马拉维正在进行和未来的卫生研究至关重要，反映了马拉维的优势 合作机构（马里兰大学、密歇根州立大学、密歇根州立大学） Witwatersrand），并与马拉维大学内的新兴机会创造协同效应。叉- 严谨、创新、执行良好且经过专业分析的研究将解决疟疾的具体挑战 治疗、预防和减少传播。此外，本次培训中所有学员开发的技能组合 拟议的努力将适用于广泛的传染病和非传染性疾病。

项目成果

Effect of adverse events on non-adherence and study non-completion in malaria chemoprevention during pregnancy trial: A nested case control study.

妊娠试验期间疟疾化学预防不良事件对不依从性和研究未完成的影响：一项巢式病例对照研究。

• 发表时间: 2022
• 影响因子: 3.7
• 作者: Patson, Noel;Mukaka, Mavuto;Peterson, Ingrid;Divala, Titus;Kazembe, Lawrence;Mathanga, Don;Laufer, Miriam K;Chirwa, Tobias
• 通讯作者: Chirwa, Tobias

Comparison of statistical methods for the analysis of recurrent adverse events in the presence of non-proportional hazards and unobserved heterogeneity: a simulation study.

在存在不成比例的危险和未观察到的异质性的情况下分析复发性不良事件的统计方法的比较：一项模拟研究。

• 发表时间: 2022-01-20
• 影响因子: 4
• 作者: Patson, Noel;Mukaka, Mavuto;Kazembe, Lawrence;Eijkemans, Marinus J C;Mathanga, Don;Laufer, Miriam K;Chirwa, Tobias
• 通讯作者: Chirwa, Tobias

Probe-based multiplex qPCR identifies blood-meal hosts in Anopheles mosquitoes from Papua New Guinea.

基于探针的多重 qPCR 鉴定了巴布亚新几内亚按蚊的血粉宿主。

• 发表时间: 2020-02-28
• 影响因子: 3.2
• 作者: Keven, John B;Artzberger, Georgia;Gillies, Mary L;Mbewe, Rex B;Walker, Edward D
• 通讯作者: Walker, Edward D

Nonrandom Selection and Multiple Blood Feeding of Human Hosts by Anopheles Vectors: Implications for Malaria Transmission in Papua New Guinea.

按蚊媒介对人类宿主的非随机选择和多次血液喂养：对巴布亚新几内亚疟疾传播的影响。

• 发表时间: 2021-09-27
• 作者: Keven, John B;Katusele, Michelle;Vinit, Rebecca;Rodríguez;Hetzel, Manuel W;Robinson, Leanne J;Laman, Moses;Karl, Stephan;Foran, David R;Walker, Edward D
• 通讯作者: Walker, Edward D

Joint modelling of multivariate longitudinal clinical laboratory safety outcomes, concomitant medication and clinical adverse events: application to artemisinin-based treatment during pregnancy clinical trial.

多变量纵向临床实验室安全结果、伴随用药和临床不良事件的联合建模：在妊娠临床试验期间以青蒿素为基础的治疗中的应用。

• 发表时间: 2021-10-09
• 影响因子: 4
• 作者: Patson, Noel;Mukaka, Mavuto;D'Alessandro, Umberto;Chapotera, Gertrude;Mwapasa, Victor;Mathanga, Don;Kazembe, Lawrence;Laufer, Miriam K;Chirwa, Tobias
• 通讯作者: Chirwa, Tobias