Mutant Mouse Resource and Research Center at UC Davis

加州大学戴维斯分校突变小鼠资源和研究中心

• 批准号: 10341114
• 负责人: KC KENT LLOYD
• 金额: $ 134.91万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10341114
• 关键词: Accountability; Advisory Committees; Animal Model; Archives; Area; Behavioral; Biocompatible Materials; Biomedical Research; Breeding; CRISPR/Cas technology; Caring; Collaborations; Communities; Complement; Crossbreeding; Cryopreservation; Data; Deposition; Development; Disease; Disease model; ES Cell Line; Embryo; Ensure; FAIR principles; Fee-for-Service Plans; Feedback; Fostering; Funding; Gene Targeting; Genetic; Genetic Engineering; Genetic Variation; Genotype; Germ Cells; Goals; Guidelines; Health; Health Services Accessibility; Human; Human Genetics; Informatics; Infrastructure; Investigation; Knock-out; Maintenance; Malignant Neoplasms; Marketing; Metabolic; Methods; Mission; Missouri; Modeling; Mouse Strains; Mus; Mutant Strains Mice; Names; Nerve Degeneration; North Carolina; Pathogenicity; Phenotype; Play; Policies; Prevention strategy; Procedures; Process; Protocols documentation; Quality Control; Recommendation; Recovery; Registries; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; Role; Scientist; Services; Social Responsibility; Surveys; System; Technology; Testing; The Jackson Laboratory; Tissues; Transgenic Organisms; United States; United States National Institutes of Health; Universities; Validation; Work; data sharing; developmental genetics; diagnostic strategy; embryonic stem cell; genome editing; gut microbiome; high risk; high standard; human disease; human model; improved; meetings; member; microbiota; mouse genetics; mouse model; new technology; novel diagnostics; pathogen; preservation; prevent; programs; repository; research study; treatment strategy

ABSTRACT: Overall Section The Mutant Mouse Resource and Research Center (MMRRC) Consortium is the nation’s primary mutant mouse archive and distribution repository system. The MMRRC Consortium was established by the NIH to ensure the preservation, dissemination, and development of valuable mutant mouse strains and data generated by research scientists, and especially now plays a key role in supporting rigor and reproducibility of experimental results using model animals. The MMRRC Consortium was constituted as a trans-national regionally-distributed network of four Centers each hosting an archive and distribution repository, one of which is located at UC Davis (MMRRC-UCD), and an Informatics Coordination and Service Center (ICSC), also coincidentally located at UC Davis. In coordination with other members of the MMRRC Consortium, the MMRRC-UCD serves the needs of the nation’s biomedical research community by ensuring access to and optimizing utilization of transgenic, knockout and other genetically engineered mutant mice and related biomaterials, services, and new technologies. To do so, the MMRRC-UCD imports, verifies, maintains, and distributes mice, gene-targeted embryonic stem (ES) cells, and germplasm of genetically unique, scientifically valuable mice that are essential for contemporary translational biomedical research. The MMRRC-UCD also provide services and procedures to assist investigators using genetically-altered mice for research in numerous areas including cancer, neurodegenerative, metabolic, developmental, genetic, and other diseases. Finally, the MMRRC-UCD conducts resource-related research and develops and refines technologies, that add scientific value to submitted mutant mouse strains, and that capitalize on the power of mouse genetics for biomedical research. By submitting their mice to the MMRRC Consortium, and upon acceptance, assignment, and deposition into the MMRRC-UCD (or any of the other 3 Centers), investigators fulfill their obligation under the NIH Data and Resource Sharing Policies. In return, the MMRRC-UCD strives to preserve, protect, quality control, and provide mouse models for study by research scientists and investigators across the nation and the globe. Through surveys and feedback from our users, discussions with our MMRRC Consortium colleagues and NIH Program representatives, input from our Internal Advisors, and engagement with the MMRRC External Advisory Committee (EAC) of experts, the long-term sustainability and relevance of the MMRRC-UCD to the biomedical research will be assured for years to come.

摘要：总体部分 突变小鼠资源和研究中心 (MMRRC) 联盟是国家主要的突变小鼠 MMRRC 联盟是由 NIH 建立的。 确保有价值的突变小鼠品系和数据的保存、传播和开发 由研究科学家产生，特别是现在在支持严谨性和可重复性方面发挥着关键作用 使用模型动物的实验结果 MMRRC 联盟是一个跨国组织。 由四个中心组成的区域分布式网络，每个中心托管一个档案和分发存储库，其中一个 位于加州大学戴维斯分校 (MMRRC-UCD)，以及信息学协调和服务中心 (ICSC)， 巧合的是，在与 MMRRC 联盟的其他成员协调下，该项目位于加州大学戴维斯分校。 MMRRC-UCD 通过确保获得和 优化利用转基因、敲除和其他基因工程突变小鼠及相关 为此，MMRRC-UCD 进口、验证、维护和开发生物材料、服务和新技术。 以科学的方式分发小鼠、基因靶向胚胎干 (ES) 细胞和遗传独特的种质 MMRRC-UCD 也对当代转化生物医学研究至关重要。 提供服务和程序来协助研究人员使用转基因小鼠进行研究 许多领域包括癌症、神经退行性疾病、代谢、发育、遗传和其他疾病。 最后，MMRRC-UCD 开展与资源相关的研究并开发和完善技术，这增加了 提交的突变小鼠品系的科学价值，并利用小鼠遗传学的力量 通过将小鼠提交给 MMRRC 联盟，并在接受、分配后， 并存入 MMRRC-UCD（或任何其他 3 个中心），调查人员履行其义务 NIH 数据和资源共享政策 作为回报，MMRRC-UCD 致力于保存、保护质量。 控制，并为全国和世界各地的研究科学家和调查人员的研究提供小鼠模型 通过我们用户的调查和反馈以及与 MMRRC 联盟同事的讨论。 和 NIH 项目代表、我们内部顾问的意见以及与 MMRRC 的合作 外部专家咨询委员会 (EAC)、MMRRC-UCD 的长期可持续性和相关性 生物医学研究将在未来几年得到保证。