Administrative Core

行政核心

基本信息

批准号：
10621826
负责人：
THOMAS M WISNIEWSKI
金额：
$ 12.96万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10621826
关键词：
Accountability Advisory Committees Agreement Alzheimer&apos s Disease Alzheimer&apos s disease model Alzheimer&apos s disease pathology Alzheimer&apos s disease related dementia Amyloid Amyloid beta-Protein Animal Model Apolipoprotein E Apolipoproteins Automobile Driving Bioinformatics Biological Biological Markers Caregivers Charge Clinic Cognitive Collaborations Communities Data Data Analyses Development Discipline Disease Disputes Education Ensure Event Experimental Designs Fostering Future Goals Grant Health Human Resources Immunology Institution Interdisciplinary Study Methodology Methods Molecular Conformation Neurology Pathogenesis Pathway interactions Patients Pharmaceutical Chemistry Play Policies Positioning Attribute Program Research Project Grants Progress Reports Protein Conformation Protein Isoforms Proteomics Quality Control Recording of previous events Research Research Personnel Research Project Grants Research Proposals Resources Role Scientist Series Structure Therapeutic Translating United States National Institutes of Health chemical resource data management data sharing human tissue immunoregulation knowledge base meetings mouse model multidisciplinary neuroimaging neuropathology novel strategies operation pre-clinical programs response responsible research conduct success synergism tau aggregation therapeutic development

项目摘要

CORE A- SUMMARY/ABSTRACT Our ultimate goal of this program grant is to gain a better understanding of the heterogeneous pathogenesis of AD and how it is influenced by apolipoprotein (apo) E isotypes, using human tissue, with correlations to findings in various AD models, using proteomic and other methods which we have recently developed. In particular we are focusing on the differential role apolipoprotein E (apoE) isoforms play in: 1) AD plaque and vessel amyloid development (Project 1); 2) therapeutic approaches that target the Aβ/apoE interaction (Project 2); 3) responses to therapeutic immunomodulation targeting abnormal conformation (Project 3). The Administrative Core (Core A) is charged with ensuring the success of this research proposal. The Aims are: Aim 1. Provide administrative structure and fiscal oversight for the program project grant. Aim 2. Organize regular meetings of the Executive Committee (EC) composed of Project and Core Leaders and other key personnel to assist in scientific administration and to facilitate integration and continuing progress on research aims. Aim 3. Coordinate with the bioinformatics/statistical/data management Core D to ensure optimal data utilization and scientific rigor for the Program Project. Aim 4. Interact closely with the External Advisory Committee and Internal Advisory Board, and conduct regular meetings of both. The External Advisory Committee and Internal Advisory Board will provide scientific advice and guidance for all research projects. Aim 5. Report progress to NIH and ensure compliance with the NIH Public Access policy. Aim 6. Promote education on AD and related disorders, and facilitate P01 scientists’ participation in education to researchers, clinicians and patients/caregivers.

核心 A- 总结/摘要我们这项计划资助的最终目标是更好地了解异质性发病机制 AD 及其如何受到载脂蛋白 (apo) E 同种型的影响，使用人体组织，与使用我们最近开发的蛋白质组学和其他方法在各种 AD 模型中发现的结果。我们特别关注载脂蛋白 E (apoE) 同工型在以下方面发挥的不同作用：1) AD 斑块和血管淀粉样蛋白发育（项目 1）；针对 Aβ/apoE 相互作用的治疗方法（项目 2); 3) 针对异常构象的治疗性免疫调节反应（项目 3）。行政核心（核心 A）负责确保本研究计划的成功。目标是：目标 1. 为计划项目拨款提供行政结构和财政监督。目标 2. 组织由项目和核心领导人组成的执行委员会 (EC) 定期会议和其他关键人员协助科学管理并促进整合和持续研究目标的进展。目标 3. 与生物信息学/统计/数据管理核心 D 协调，确保最佳数据计划项目的利用和科学研究。目标 4. 与外部咨询委员会和内部咨询委员会密切互动，定期开展外部咨询委员会和内部咨询委员会的会议将提供科学建议。以及所有研究项目的指导。目标 5. 向 NIH 报告进展情况并确保遵守 NIH 公共访问政策。目标6.促进AD及相关疾病的教育，促进P01科学家参与教育研究人员、牧师和患者/护理人员。