Validity of DSM-IV Subtypes of ADHD for Young Children

DSM-IV ADHD 亚型对幼儿的有效性

• 批准号: 7669086
• 负责人: Benjamin B Lahey
• 金额: $ 26.09万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-02-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7669086
• 关键词: 18 year old; 6 year old; Accidental Injury; Address; Adolescence; Adolescent; Adopted; Age; Alcohol or Other Drugs use; Anxiety Disorders; Attention deficit hyperactivity disorder; Bipolar Disorder; Characteristics; Child; Child Behavior; Childhood; Classification; Conduct Disorder; Confounding Factors (Epidemiology); DSM-IV; DSM-V; Data; Data Analyses; Decision Making; Development; Diagnosis; Diagnostic; Drops; Ethnic Origin; Evaluation; Exhibits; Funding; Future; Impairment; Intelligence; Learning; Longitudinal Studies; Maps; Measures; Mental Health; Mental disorders; Mind; Modeling; Mood Disorders; Moods; Nursery Schools; Oppositional Defiant Disorder; Outcome; Parenting behavior; Parents; Pattern; Pharmaceutical Preparations; Preschool Child; Prevention; Process; Psychopathology; Psychosocial Factor; Race; Recovery; Reporting; Risk; Sampling; Scheme; Schools; Socioeconomic Status; Structure; Substance abuse problem; Symptoms; Taxonomy; Testing; Time; Unipolar Depression; Ursidae Family; Variant; Youth; base; depression; early childhood; experience; follow-up; functional disability; high risk sexual behavior; improved; parental influence; proband; psychosocial; social; theories; vehicular accident; working group

DESCRIPTION (provided by applicant): In this revised application, we propose to conduct annual assessments through 18 years of age to complete an ongoing longitudinal study of the predictive validity of DSM-IV criteria for attention-deficit/ hyperactivity disorder (ADHD) when it is first diagnosed at 4-6 years of age. It is important to evaluate the predictive validity of ADHD in young children, partly because of the documented increase in the use of psychoactive medications in preschool children. Because all treatments confer some risk, it is essential to know if the DSM-IV criteria for ADHD accurately identify younger children with significant functional impairment and adverse long-term outcomes. The sample consists of 125 ADHD probands and 130 well-matched nonreferred comparison children who are currently being assessed in their tenth annual assessments. In order to inform decision making for DSM-V, we will use the proposed adolescent follow-ups to address the predictive validity of the diagnostic criteria for ADHD, including symptoms and thresholds, the validity of the subtypes of ADHD, and the appropriateness of age-specific symptoms and diagnostic thresholds. The present study has the advantages of using DSM-IV diagnostic criteria and beginning annual structured diagnostic assessments at an early age. When completed, this study will provide the first detailed mapping of the developmental course of DSM-IV ADHD, including developmental progressions from ADHD to other mental health outcomes (conduct problems, unipolar depression, bipolar disorder, anxiety disorders, and substance use) from early childhood through adolescence. Because we expect ADHD probands to exhibit declining average levels of ADHD symptoms over time, we will adopt a developmental approach to predictive validity. That is, we predict that probands whose ADHD symptoms persist into adolescence will be more likely to exhibit impaired functioning and experience other adverse mental health outcomes in adolescence. If this hypothesis is confirmed, as preliminary findings suggest, we will test key hypotheses regarding early child characteristics and potential psychosocial factors that may predict future persistence versus recovery in ADHD symptoms and impairment. Similarly, we will determine if these early child characteristic and psychosocial factors allow differential prediction of other adolescent mental health outcomes. Answering these questions will inform taxonomy, etiologic theory, and assist future efforts at targeted prevention.

描述（由申请人提供）：在此修订后的申请中，我们建议在18岁时进行年度评估，以完成对DSM-IV标准对注意力缺陷/多动症（ADHD）的预测有效性（ADHD）的持续纵向研究。重要的是要评估年幼儿童的多动症的预测有效性，部分原因是在学龄前儿童中使用了精神活性药物的增加。因为所有治疗都赋予某种风险，因此必须知道ADHD的DSM-IV标准是否准确地识别出具有重大功能障碍和不良长期结果的年幼儿童。该样本包括125个ADHD概率和130个匹配的非参考比较儿童，目前正在其第十个年度评估中进行评估。为了告知DSM-V的决策，我们将使用拟议的青少年随访来解决ADHD诊断标准的预测有效性，包括症状和阈值，ADHD的亚型的有效性以及年龄特异性症状和诊断阈值的适当性。本研究的优点是使用DSM-IV诊断标准，并从小就开始年度结构化诊断评估。完成后，这项研究将提供DSM-IV ADHD发育过程的首次详细映射，包括从ADHD到其他心理健康结果（行为问题，单极抑郁症，双相情感障碍，焦虑症和药物使用）的发育进展。因为我们预计ADHD概率随着时间的推移会表现出平均ADHD症状水平下降，因此我们将采用一种发展方法来预测有效性。也就是说，我们预测，其多动症症状持续到青春期的可能性更可能在青春期表现出功能受损并经历其他不利的心理健康结果。如初步发现所表明的那样，如果确认了这一假设，我们将检验有关早期儿童特征和潜在的社会心理因素的关键假设，这些假设可能预测了未来的持久性与多动症症状和损害的恢复。同样，我们将确定这些早期的儿童特征和社会心理因素是否允许对其他青少年心理健康结果的差异预测。回答这些问题将为分类学，病因理论提供依据，并协助未来的针对预防努力。

项目成果

The Effects of Stimulant Medication and Training on Sports Competence Among Children With ADHD.

• DOI: 10.1080/15374416.2016.1270829
• 发表时间: 2019
• 期刊: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
• 作者: Altszuler AR;Morrow AS;Merrill BM;Bressler S;Macphee FL;Gnagy EM;Greiner AR;Coxe S;Raiker JS;Coles E;Pelham WE Jr
• 通讯作者: Pelham WE Jr

Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms.

• DOI: 10.1037/a0021133
• 发表时间: 2011-02
• 期刊: JOURNAL OF ABNORMAL PSYCHOLOGY
• 影响因子: 4.6
• 作者: Lahey, Benjamin B.;Rathouz, Paul J.;Lee, Steve S.;Chronis-Tuscano, Andrea;Pelham, William E.;Waldman, Irwin D.;Cook, Edwin H.
• 通讯作者: Cook, Edwin H.

Examining Parents' Preferences for Group and Individual Parent Training for Children with ADHD Symptoms.

• DOI: 10.1080/15374416.2015.1004678
• 发表时间: 2016-09
• 期刊: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
• 作者: Wymbs FA;Cunningham CE;Chen Y;Rimas HM;Deal K;Waschbusch DA;Pelham WE Jr
• 通讯作者: Pelham WE Jr

Preliminary genetic imaging study of the association between estrogen receptor-α gene polymorphisms and harsh human maternal parenting.

• DOI: 10.1016/j.neulet.2012.07.016
• 发表时间: 2012-09-06
• 期刊: Neuroscience letters
• 影响因子: 2.5
• 作者: Lahey BB;Michalska KJ;Liu C;Chen Q;Hipwell AE;Chronis-Tuscano A;Waldman ID;Decety J
• 通讯作者: Decety J

Atypical empathic responses in adolescents with aggressive conduct disorder: a functional MRI investigation.

• DOI: 10.1016/j.biopsycho.2008.09.004
• 发表时间: 2009-02
• 期刊: Biological psychology
• 影响因子: 2.6
• 作者: Decety J;Michalska KJ;Akitsuki Y;Lahey BB
• 通讯作者: Lahey BB