Arizona Center for Education and Research on Therapeutics

亚利桑那治疗学教育与研究中心

• 批准号: 7682239
• 负责人: Raymond Leon Woosley
• 金额: $ 99.98万
• 依托单位: CRITICAL PATH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7682239
• 关键词: Arizona; Center; Education; Research; Therapeutics

DESCRIPTION (Provided by the Applicant): The Arizona CERT (AzCERT) is a consortium of the University of Arizona (UA) and the Critical Path Institute (C-Path), a non-profit organization in Tucson, AZ. The AzCERT has six years of experience in the prevention of adverse drug reactions (ADDRs) associated with drug-drug interactions (DDIs), especially those that harm women. This application expands on this theme using a systems approach to examine the underlying human and systems factors responsible for the co-prescription, co-dispensing and co-administration of drug combinations that have the potential to interact (PDDIs) and cause ADDRs. Our specific aims are to 1) improve patient safety by reducing PDDIs and 2) improve health outcomes by reducing ADDRs. Research will examine the effectiveness of provider-targeted and patient-targeted interventions on PDDIs and ADDRs. The AzCERT will continue its very productive collaborations with the Veterans Administration Healthcare System to evaluate the effectiveness of alerts to physicians for preventing PDDIs and ADDRs. We will also evaluate the effectiveness of a "near real time" fax alert program that includes Medicare Part D prescribers for prevention of PDDIs and ADDRs in medication management call centers (UA and Caremark). We will evaluate innovative PDDI educational interventions that take place in community settings, including clinical laboratories and community health centers (CHC) and capture the "teachable moment" when patients are waiting to have blood drawn for monitoring warfarin, digoxin and other drug therapies. AzCERT will develop and evaluate innovative "train-the-trainer" programs as part of the inter-professional curriculum in the UA colleges of nursing, medicine and pharmacy. The AzCERT has well-established international (web-based), national, regional and community educational and dissemination programs that are based on research conducted by AzCERT and others. The internationally recognized website, QTdrugs.org (360,000 visits in 2005) will be expanded and made more interactive through collaborations with the FDA, Lincoln Technologies and DrugLogic. Together with the FDA, AMA and the American College of Clinical Pharmacology, we will inform providers and patients about DDI and new gene-based dosing for warfarin through multiple approaches including a new website, www.warfarin-ddi.org. In this application, we will greatly expand our dissemination efforts to include public service announcements featuring former U.S. Surgeon General Richard Carmona. All of this work will focus on evidence-based, culturally sensitive interventions, thorough evaluation and dissemination of information that is relevant to patients, especially the Hispanic, Native American and under-served urban and rural populations in AZ. Dissemination will be facilitated by collaborative relationships with the AZ Association of CHCs, clinical laboratories, the Area Health Education Centers (AHEC), UA College of Agriculture Cooperative Extension and Cox Cable. The AzCERT will leverage the federal funding for this grant through partnerships that extend our reach and our ability to improve health outcomes for patients.

描述（由申请人提供）：亚利桑那州证书（AZCERT）是亚利桑那大学（UA）（UA）的联盟和AZ图森市的非营利组织的关键路径研究所（C-Path）。 AZCERT在预防与药物相互作用（DDIS）相关的不良药物反应（ADDR）方面具有六年的经验，尤其是那些伤害妇女的人。该应用程序使用系统方法扩展了该主题，以检查负责具有相互作用（PDDIS）并引起ADDR的药物组合的共同处方，共同分配和共同给药的基本人和系统因素。我们的具体目的是1）通过减少PDDI来提高患者安全性，并2）通过减少ADDR来改善健康结果。研究将研究针对PDDIS和ADDR的靶向提供者和患者靶向的干预措施的有效性。 AZCERT将继续与退伍军人管理局医疗体系的富有成效的合作，以评估对医生预防PDDIS和ADDR的警报的有效性。我们还将评估“接近实时”传真警报计划的有效性，该计划包括Medicare D部分，以预防PDDIS和ADDRS在药物管理呼叫中心（UA和Caremark）中。我们将评估在社区环境中进行的创新PDDI教育干预措施，包括临床实验室和社区卫生中心（CHC），并捕捉患者等待吸血以监测华法林，地高辛和其他药物治疗的“可教时刻”。 AZCERT将开发和评估创新的“火车培训”计划，这是UA护理，医学和药学学院的专业课程的一部分。 AZCERT拥有良好的国际（基于网络），国家，地区和社区教育和传播计划，这些计划基于Azcert和其他人进行的研究。国际认可的网站QTDRUGS.org（2005年360,000次访问）将通过与FDA，Lincoln Technologies和Fungogic的合作进行扩展，并使互动更加互动。与FDA，AMA和美国临床药理学学院一起，我们将通过包括新网站www.warfarin-ddi.org在内的多种方法通知提供者和患者有关DDI和新的基于基因的剂量。在此应用程序中，我们将大大扩展我们的传播工作，包括前美国外科医生理查德·卡莫纳（Richard Carmona）的公共服务公告。所有这些工作都将集中在基于证据的，具有文化敏感的干预措施，对与患者有关的信息（尤其是西班牙裔，美洲原住民和服务不足的城市和农村人口）相关的信息的全面评估和传播。与AZ的CHC，临床实验室，地区健康教育中心（AHEC），UA农业合作扩展学院和Cox Cable的合作关系将通过与AZ的协作协会，临床实验室，地区健康教育中心（AHEC）和Cox有线关系来促进传播。 AZCERT将通过促进我们的影响力和改善患者健康成果的能力来利用这笔赠款的联邦资金。