US CRITICAL ILLNESS AND INJURY TRAILS GROUP

美国危重疾病和伤害追踪小组

• 批准号: 7599509
• 负责人: J PERREN COBB
• 金额: $ 4.79万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-09-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7599509
• 关键词: Acute; Address; Adult; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Clinical; Clinical Protocols; Clinical Trials; Clinical Trials Design; Collaborations; Communication; Critical Care; Critical Illness; Data; Development; Disease; Funding; Goals; Grant; Group Meetings; Injury; Institutes; Measures; NIH Program Announcements; Organ; Outcome; Patients; Population; Preparation; Privacy; Publishing; Reporting; Research; Science; Sorting - Cell Movement; System; Testing; Training; United States National Institutes of Health; Writing; base; disability; ethical legal social implication; evidence base; improved; injured; meetings; programs; success

DESCRIPTION (provided by applicant): Critical illness and injury are leading causes of death and disability world- wide. Despite our nation's expertise and the imperative to improve outcomes for the critically ill and injured, the US does not have a federally-funded critical care research network for adults. Instead, funding for critical illness and injury research is divided along organ-based or disease-based lines across federal agencies, including but not limited to institutes and offices within the NIH, CDC, and DOD, among others. Moreover, there is little interaction between many existing NIH large-scale critical illness and injury research programs. As a result, there has been a call for better communication, synergy, and funding efficiency at a national level, thereby improving the breadth and quality of acute care research. Indeed, the emergence of a systems-based approach for the study of critical illness and injury demands this sort of scientific and inter-agency interaction, as reflected by recent NIH trans-Institute program announcements. To address these needs, this grant will create a US Critical Illness and Injury Trials Group (USCIITG) meeting. The Group will facilitate collaboration among experts with the goal of promoting clinical trials in the critically ill or injured. This grant will not fund clinical trials per se, but rather promote at quarterly meetings the development of evidence-based clinical protocols and the subsequent preparation of applications for funding to test specific hypotheses. The specific aims include the following: 1) Establish an inclusive, nationwide network of experts to review published data, establish national priorities, vet hypotheses, write clinical protocols, and generate pilot data; 2) Promote interaction and synergy across established programs, both academic and non-academic, to improve the robustness of clinical trails and test hypotheses in a US population; 3) Provide a venue to educate and train clinicians of all backgrounds in the science of trial design, conduct, analysis, and reporting; 4) Insure patient protection and privacy by addressing the ethical, legal, and social implications (ELSI) of research in the specialized circumstance of critical illness or injury. The USCIITG will be governed by steering and organizational committees. The USCIITG will convene yearly meetings at the NIH Bethesda campus, with interval quarterly meetings held in conjunction with the annual meetings of critical illness and injury professional societies.Lay Summary This grant will create a US Critical Illness and Injury Trials Group meeting. The Group will facilitate collaboration among experts with the goal of promoting clinical trials in the field of critical illness and injury. The success of the Group will be measured by the number of new grants funded to test hypotheses in clinical trails in the critically ill or injured.

描述（由申请人提供）：严重疾病和伤害是死亡和残疾世界的主要原因。尽管我们国家的专业知识是改善重症危害和受伤的结果的当务之急，但美国没有为成人提供联邦资助的重症监护研究网络。取而代之的是，对重症疾病和伤害研究的资金沿着联邦机构的基于器官或疾病的线路分配，包括但不限于NIH，CDC和DOD等人的机构和办公室。此外，许多现有的NIH大规模重症疾病与伤害研究计划之间几乎没有相互作用。结果，呼吁在国家一级寻求更好的沟通，协同作用和资金效率，从而提高了急性护理研究的广度和质量。确实，正如最近的NIH NIH跨学院计划公告所反映的那样，一种基于系统的方法研究重症疾病和伤害的方法需要这种科学和机构间的互动。为了满足这些需求，这笔赠款将创建美国重症疾病和伤害试验小组（USCIITG）会议。该小组将促进专家之间的合作，以促进重病或受伤的临床试验。该赠款本身不会为临床试验提供资金，而是在季度会议上促进基于证据的临床方案的开发以及随后准备资金的申请以检验特定假设的申请。具体目的包括以下内容：1）建立一个包容性的全国专家网络，以审查已发布的数据，建立国家优先事项，兽医假设，编写临床方案并生成试点数据； 2）在学术和非学术方面的既定计划中促进互动和协同作用，以提高美国人群中临床踪迹和检验假设的鲁棒性； 3）提供一个在试验设计，行为，分析和报告科学科学方面教育和培训各个背景的临床医生的场所； 4）在重症或伤害的专业情况下，通过解决研究的道德，法律和社会含义（ELSI）来确保患者的保护和隐私。 USCIITG将由转向和组织委员会管辖。 USCIITG将在NIH Bethesda校园举行年度会议，并在季度会议上与重症和伤害专业社会的年度会议一起举行。 该赠款将创建美国重症疾病和伤害试验小组会议。该小组将促进专家之间的合作，目的是促进重症和伤害领域的临床试验。该小组的成功将通过资助的新赠款数量来衡量，这些赠款的数量用于检验重症或受伤的临床踪迹中的假设。