Physiological Genomics of Critical Illness and Injury

危重疾病和损伤的生理基因组学

基本信息

批准号：
8019276
负责人：
J PERREN COBB
金额：
$ 12.63万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2010-02-28
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Organ failure syndromes that cause substantial morbidity and death often complicate critical illness due to severe infection or traumatic injury. Recent advances in computational biology and high-throughput technologies (e.g. microarrays, highly parallel single nucleotide polymorphism (SNP) analysis, and proteomics) have generated considerable interest in developing a more global understanding of complex biological systems. The application of these technologies to critical illness offers the potential to define maladaptive programs of gene expression induced by infection, trauma or other inflammatory triggers and to detect biomarkers and genetic polymorphisms that are associated with these responses. These tools also provide a means to discover novel gene function and to identify potential therapeutic targets. Investigators that plan to use genomic and proteomic approaches to study critical illness and injury are presented with major challenges regarding the unique demands that these methods place on resources, experimental design, and analysis. Furthermore, investigations in this setting face unique requirements related to patient safety, vulnerability, and privacy as well as other ethical considerations specific to performing genomic research. The Functional Genomics of Critical Illness and Injury Symposium has been held annually for the past two years to address these needs (www.cc.nih.gov/ccmd/Symposium/). This application seeks funding for the Physiological Genomics of Critical Illness and Injury Symposium (April 21-22, 2005), the goal of which is to bring together those with the diverse skills sets necessary to apply genomics and systems analysis to the study of critical illness and injury. The objectives are three-fold: education, consensus, and collaboration. Importantly, there is no other venue by which this group of investigators might meet to discuss the application of genomic technology, ethics, and human values to the study of critical illness and injury.

描述（由申请人提供）：导致大量发病率和死亡的器官衰竭综合征通常会因严重感染或创伤性损伤而复杂化。计算生物学和高通量技术的最新进展（例如，微阵列，高度平行的单核苷酸多态性（SNP）分析和蛋白质组学）对发展对复杂的生物系统的更全球性了解产生了极大的兴趣。这些技术在危害疾病中的应用提供了定义受感染，创伤或其他炎症触发诱导的基因表达不良计划的潜力，并检测与这些反应相关的生物标志物和遗传多态性。这些工具还提供了一种发现新型基因功能并确定潜在治疗靶标的方法。计划使用基因组和蛋白质组学方法来研究重症疾病和伤害的研究者面临着这些方法在资源，实验设计和分析上的独特需求面临的主要挑战。此外，在这种情况下的调查面临与患者有关的独特要求安全，脆弱性和隐私以及其他特定于执行基因组的道德考虑因素研究。在过去的两年中，每年举行了严重疾病和伤害研讨会的功能基因组学（www.cc.nih.gov/ccmd/symposium/）。该应用程序为重症疾病和损伤研讨会的生理基因组学寻求资金（2005年4月21日至22日），其目的是将具有多种技能的人聚集在一起，以将基因组学和系统分析应用于重症疾病和伤害的研究所需的各种技能。目标是三个方面：教育，共识和协作。重要的是，没有其他场所可以在其中讨论基因组技术，伦理和人类价值观在重症疾病和伤害研究中的应用。