Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research

指导临床研究人员进行青少年发作的药物使用障碍研究

基本信息

批准号：
10425382
负责人：
Christian J Hopfer
金额：
$ 18.33万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10425382
关键词：
Adolescent Anesthesiology Area Award Behavioral Genetics Biological Markers Biometry Clinical Clinical Investigator Collaborations Colorado Development Discipline Disease Doctor of Medicine Doctor of Philosophy Educational process of instructing Epidemiology Etiology Family Family Study Funding Genetic Goals Grant Individual Joints K-Series Research Career Programs Leadership Marijuana Maternal-fetal medicine Measurement Medical Students Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Mission Molecular Molecular Genetics Molecular and Cellular Biology National Institute of Drug Abuse Outcome Paper Pediatrics Pharmacology Proteomics Psychiatry Public Health Research Research Design Research Personnel Research Training Role Substance Use Disorder Substance abuse problem Systems Biology Technology Time Toxicology Training Twin Multiple Birth Universities Work Writing Youth addiction behavioral outcome biomarker discovery career career development developmental psychobiology education research genetic approach high risk lipidomics marijuana legalization marijuana use medical schools metabolomics patient oriented patient oriented research programs public health relevance responsible research conduct senior faculty skills student training substance use success transcriptome sequencing

项目摘要

The primary goals of this K24 competing renewal application are to enable Christian Hopfer, M.D. to conduct career development activities to enhance his patient-oriented addiction research and to provide high-quality mentorship to early-career investigators. The renewal will enable Dr. Hopfer to have protected time to devote to career development and mentoring of clinical researchers. Dr. Hopfer was promoted to Full Professor of Psychiatry at the University of Colorado School of Medicine due to the success of his research, teaching, and clinical program. Dr. Hopfer's major goals of his initial award were accomplished with obtaining and leading a NIDA funded R25 medical student research education program, acting as the executive director of the Developmental Psychobiology Research Group (DPRG) whose affiliated T32 program was renewed, obtaining new research funding, and mentoring junior investigators. Dr.Hopfers' research plan for this renewal application involves continued work as a PI on NIDA funded research focused on understanding genetic and environmental influences on the progression or desistance of substance use disorders among high-risk youth utilizing a joint twin/family study design as well as understanding the impact of legal marijuana access on psychiatric and behavioral outcomes. He plans to expand his search for biomarkers for substance use disorders that have been previously conducted utilizing molecular genetic approaches to now include proteomic, metabolomics, RNA-seq, and lipidomic approaches. Dr.Hopfer mentors trainees in multiple areas of research training including: 1) Understanding clinical aspects of substance use and abuse, 2) Twin/family and molecular approaches to examining the etiology of substance use and correlated disorders, 3) Preparing scientific papers and presenting findings, 4) Developing and writing successful project proposals, and 5) conducting responsible research. He will accomplish his training mission through individual and group mentoring and collaborating with key colleagues with expertise in biostatistics and state of the art measurement technologies for identifying biomarkers of substance use.

这个 K24 竞争性续订应用程序的主要目标是让 Christian Hopfer，医学博士开展职业发展活动以增强以患者为中心的毒瘾研究并为早期职业研究人员提供高质量的指导。此次续签将使 Hopfer 博士有足够的时间致力于职业发展和指导临床研究人员。霍普弗博士晋升为英国大学精神病学正教授科罗拉多医学院因其研究、教学和临床项目的成功而获得博士学位。霍普弗博士最初获奖的主要目标是通过获得并领导一个 NIDA资助R25医学生研究教育项目，担任执行主任发育心理生物学研究小组 (DPRG) 的附属 T32 项目更新，获得新的研究经费，并指导初级研究人员。 Hopfers 博士针对此次更新申请的研究计划包括继续担任 NIDA 的 PI 工作资助的研究重点是了解遗传和环境对使用关节的高危青少年中物质使用障碍的进展或停止双胞胎/家庭研究设计以及了解合法大麻获取的影响精神和行为结果。他计划扩大对生物标志物的搜索以前利用分子遗传学进行过的物质使用障碍目前的方法包括蛋白质组学、代谢组学、RNA-seq 和脂质组学方法。 Hopfer 博士在多个研究培训领域指导学员，包括： 1) 理解物质使用和滥用的临床方面，2) 双胞胎/家庭和分子方法检查物质使用和相关疾病的病因，3) 准备科学论文并展示研究结果，4) 制定和撰写成功的项目提案，以及 5) 进行负责任的研究。他将通过个人和与具有生物统计学和现状专业知识的主要同事进行小组指导和合作用于识别物质使用生物标志物的艺术测量技术。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Adolescents in Treatment for Substance Use Disorders: Callous-Unemotional Traits Moderate Associations Between Transdiagnostic Symptoms and Adolescent Suicidality.

治疗药物使用障碍的青少年：冷酷无情的特征跨诊断症状与青少年自杀之间的中度关联。

DOI：
发表时间：
2023-04
期刊：
影响因子：
2.9
作者：
Winters, Drew E;Mikulich, Susan K;Hopfer, Christian;Sakai, Joseph T
通讯作者：
Sakai, Joseph T

An Approach to Biomarker Discovery of Cannabis Use Utilizing Proteomic, Metabolomic, and Lipidomic Analyses.

利用蛋白质组学、代谢组学和脂质组学分析发现大麻使用的生物标志物的方法。

DOI：
10.1089/can.2020.0002
发表时间：
2020-06-19
期刊：
Cannabis and cannabinoid research
影响因子：
0
作者：
J. Hinckley;L. Saba;Kristen M. Raymond;K. Bartels;J. Klawitter;U. Christians;Christian J. Hopfer
通讯作者：
Christian J. Hopfer

The Association of Patient Satisfaction-Based Incentives with Primary Care Physician Opioid Prescribing.

基于患者满意度的激励措施与初级保健医生阿片类药物处方的关联。

DOI：
发表时间：
2018-11
期刊：
影响因子：
0
作者：
Carrico, Jacqueline A;Mahoney, Katharine;Raymond, Kristen M;Mims, Logan;Smith, Peter C;Sakai, Joseph T;Mikulich;Hopfer, Christian J;Bartels, Karsten
通讯作者：
Bartels, Karsten