Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI

通过结构和灌注 MRI 测量酒精和压力的相互作用

基本信息

批准号：
7599715
负责人：
JAMES B DAUNAIS
金额：
$ 34.25万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-04-15 至 2011-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7599715
关键词：
Addictive Behavior Adult Affect Age Alcohol abuse Alcohol consumption Alcoholism Alcohols Algorithms Anatomic structures Animal Model Animals Area Behavioral Biomedical Computing Brain Brain region Cerebellum Cerebrovascular Circulation Cerebrum Child health care Chronic Clinic Clinical Clinical Research Collaborations Computer software Consumption Controlled Environment Corpus Callosum Data Diagnosis Disease Ensure Environment Ethanol Exposure to Funding Goals Hippocampus (Brain)Human Human Development Image Image Analysis Imaging Device Imaging Techniques Individual Institutes Life Long-Term Effects Macaca mulatta Magnetic Resonance Imaging Measures Medical Medical Imaging Methods Modeling Monitor Monkeys Mothers Neuroanatomy Neurobiology Neurologic Neurons Neurosciences Nurseries Nutritional Perfusion Perfusion Weighted MRI Physiological Play Positioning Attribute Predisposition Primates Process Recording of previous events Recovery Research Research Personnel Resolution Rodent Role Scanning Self Administration Self-Administered Stress Structure Time United States United States National Institutes of Health Virginia Work alcohol effect alcohol exposure base chronic alcohol ingestion cost design drinking early childhood experience frontal lobe gray matter insight mature animal meetings morphometry multidisciplinary multidrug abuse neuroimaging neuroinformatics nonhuman primate problem drinker programs research study translational study young adult

项目摘要

DESCRIPTION (provided by applicant): Alcohol abuse continues to be a major problem in the United States with an estimated 14 million adults meeting the clinical criteria for a diagnosis of alcohol abuse or alcoholism at an estimated cost of $185 billion. Chronic alcohol exposure has been shown to impact structure and function of the brain. Since most of what is known of alcohol's effects on the brain is based on studies of individuals who have abused for a long time, it is unclear whether some of the effects might occur early in the abuse process. Additionally, human studies are often complicated by many factors incuding polydrug abuse, poor nutritional states and other medical conditions. Another complicating factor is the interaction of stress and alcohol. Using magnetic resonance imaging (MRI), we will examine the the effects of chronic alcohol self- administration on brain structure and function in a group of monkeys that have been mother-reared or nursery-reared. MRI scans will be acquired to determine whether there are differences in stucture or functions as a result of alcohol exposure and whether rearing conditions play a role in these effects. MRI techniques will also be used to examine how chronic alcohol consumption affects cerebral blood flow, which is a measure of neuronal activity. Because we will conduct these measures both before and after alcohol exposure in the same "young adult" animals, we will be able to track any changes that might occur early in alcohol abuse which is something that cannot be accomplished in human studies. Another goal is to adapt imaging tools and computer software that are used to measure the brains of humans to the monkey brain. To accomplish this, we will collaborate with the National Alliance for Medical Computing (NA-MIC), an existing NIH Center for Biomedical Computing. We can control all variables associated with alcohol self-administration in these monkeys. They will be monitored both before and after exposure to alcohol, thus, we will be able to monitor the progression of any changes in structure or function that directly result from alcohol exposure. These studies will help identify how exposure to long-term alcohol might affect how the brain works.