Measuring Alcohol and Stress Interactions with Structural and Perfusion MRI

通过结构和灌注 MRI 测量酒精和压力的相互作用

• 批准号: 7852105
• 负责人: JAMES B DAUNAIS
• 金额: $ 5.2万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7852105
• 关键词: Addictive Behavior; Adult; Affect; Age; Alcohol abuse; Alcohol consumption; Alcoholism; Alcohols; Algorithms; Anatomic structures; Animal Model; Animals; Area; Behavioral; Biomedical Computing; Brain; Brain region; Cerebellum; Cerebrovascular Circulation; Cerebrum; Child health care; Chronic; Clinic; Clinical; Clinical Research; Collaborations; Computer software; Consumption; Controlled Environment; Corpus Callosum; Data; Diagnosis; Disease; Ensure; Environment; Ethanol; Exposure to; Funding; Goals; Hippocampus (Brain); Human; Human Development; Image; Image Analysis; Imaging Device; Imaging Techniques; Individual; Institutes; Life; Long-Term Effects; Macaca mulatta; Magnetic Resonance Imaging; Measures; Medical; Medical Imaging; Methods; Modeling; Monitor; Monkeys; Mothers; Neuroanatomy; Neurobiology; Neurologic; Neurons; Neurosciences; Nurseries; Nutritional; Perfusion; Perfusion Weighted MRI; Physiological; Play; Positioning Attribute; Predisposition; Primates; Process; Recording of previous events; Recovery; Research; Research Personnel; Resolution; Rodent; Role; Scanning; Self Administration; Self-Administered; Stress; Structure; Time; United States; United States National Institutes of Health; Virginia; Work; alcohol effect; alcohol exposure; base; chronic alcohol ingestion; cost; design; drinking; early childhood; experience; frontal lobe; gray matter; insight; mature animal; meetings; morphometry; multidisciplinary; multidrug abuse; neuroimaging; neuroinformatics; nonhuman primate; problem drinker; programs; research study; translational study; young adult

DESCRIPTION (provided by applicant): Alcohol abuse continues to be a major problem in the United States with an estimated 14 million adults meeting the clinical criteria for a diagnosis of alcohol abuse or alcoholism at an estimated cost of $185 billion. Chronic alcohol exposure has been shown to impact structure and function of the brain. Since most of what is known of alcohol's effects on the brain is based on studies of individuals who have abused for a long time, it is unclear whether some of the effects might occur early in the abuse process. Additionally, human studies are often complicated by many factors incuding polydrug abuse, poor nutritional states and other medical conditions. Another complicating factor is the interaction of stress and alcohol. Using magnetic resonance imaging (MRI), we will examine the the effects of chronic alcohol self- administration on brain structure and function in a group of monkeys that have been mother-reared or nursery-reared. MRI scans will be acquired to determine whether there are differences in stucture or functions as a result of alcohol exposure and whether rearing conditions play a role in these effects. MRI techniques will also be used to examine how chronic alcohol consumption affects cerebral blood flow, which is a measure of neuronal activity. Because we will conduct these measures both before and after alcohol exposure in the same "young adult" animals, we will be able to track any changes that might occur early in alcohol abuse which is something that cannot be accomplished in human studies. Another goal is to adapt imaging tools and computer software that are used to measure the brains of humans to the monkey brain. To accomplish this, we will collaborate with the National Alliance for Medical Computing (NA-MIC), an existing NIH Center for Biomedical Computing. We can control all variables associated with alcohol self-administration in these monkeys. They will be monitored both before and after exposure to alcohol, thus, we will be able to monitor the progression of any changes in structure or function that directly result from alcohol exposure. These studies will help identify how exposure to long-term alcohol might affect how the brain works.

描述（由申请人提供）：在美国，酗酒仍然是一个主要问题，估计有1400万成人符合诊断酗酒或酒精中毒的临床标准，估计成本为1.85亿美元。已显示慢性酒精暴露会影响大脑的结构和功能。由于大多数已知酒精对大脑影响的知识是基于对滥用长期虐待的个体的研究，因此尚不清楚某些影响是否可能在滥用过程的早期发生。此外，许多因素滥用，营养状态和其他医疗状况的许多因素通常会使人类研究变得复杂。另一个复杂因素是压力和酒精的相互作用。使用磁共振成像（MRI），我们将研究慢性酒精自我给药对一组母亲或托儿所的猴子中脑结构和功能的影响。将获得MRI扫描，以确定由于酒精暴露而导致的构成或功能差异以及饲养条件是否在这些影响中起作用。 MRI技术还将用于检查慢性饮酒如何影响脑血流，这是对神经元活性的量度。因为我们将在同一“年轻”动物中进行酒精暴露之前和之后采取这些措施，所以我们将能够跟踪酗酒早期可能发生的任何变化，这在人类研究中是无法实现的。另一个目标是调整用于测量人类大脑到猴子大脑的成像工具和计算机软件。为此，我们将与现有的NIH生物医学计算中心国家医学计算联盟（NA-MIC）合作。我们可以控制这些猴子中与酒精自给自足相关的所有变量。在暴露于酒精之前和之后，它们都将受到监测，因此，我们将能够监视直接因酒精暴露而导致的结构或功能变化的进展。这些研究将有助于确定长期酒精的接触如何影响大脑的运作方式。

项目成果

Robust EPI Nyquist ghost elimination via spatial and temporal encoding.

• DOI: 10.1002/mrm.22564
• 发表时间: 2010-12
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Hoge, W. Scott;Tan, Huan;Kraft, Robert A.
• 通讯作者: Kraft, Robert A.

Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression.

行为抑郁的绝经后食蟹猴的海马体积。

• DOI: 10.1097/gme.0b013e3181fcb47e
• 发表时间: 2011
• 期刊: Menopause (New York, N.Y.)
• 作者: Willard,StephanieL;Daunais,JamesB;Cline,JMark;Shively,CarolA
• 通讯作者: Shively,CarolA

3D GRASE PROPELLER: improved image acquisition technique for arterial spin labeling perfusion imaging.

• DOI: 10.1002/mrm.22768
• 发表时间: 2011-07
• 期刊: MAGNETIC RESONANCE IN MEDICINE
• 影响因子: 3.3
• 作者: Tan, Huan;Hoge, W. Scott;Hamilton, Craig A.;Guenther, Matthias;Kraft, Robert A.
• 通讯作者: Kraft, Robert A.