MRI Guided Interventions in the Prostate: Development of an Integrated Image-Base

MRI 引导前列腺干预：集成图像库的开发

• 批准号: 7620900
• 负责人: CLARE M TEMPANY
• 金额: $ 18.78万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7620900
• 关键词: Adverse effects; Aftercare; Algorithms; Biopsy; Brachytherapy; Clinical Trials; Data; Data Set; Development; Diagnosis; Diffusion; Discrimination; Disease; Elements; Epidemic; Feedback; Future; Gadolinium; Gland; Goals; Healthcare Systems; Image; Imagery; Intervention; Intravenous; Lead; Lesion; Localized; Location; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant neoplasm of prostate; Maps; Measurement; Medicine; Methods; Needles; Operating Rooms; Operative Surgical Procedures; Other Imaging Modalities; Patients; Peripheral; Placement; Positioning Attribute; Positron-Emission Tomography; Procedures; Prostate; Protocols documentation; Protons; Public Health; Puncture biopsy; Purpose; Quality of life; Relative (related person); Research; SSM; Scanning; Specific qualifier value; Spectrum Analysis; Spottings; Standards of Weights and Measures; Structure; Structure of capsule of prostate; Surface; System; Testing; Time; Tissues; Today; Translating; base; image registration; improved; intraoperative imaging; molecular imaging; optical imaging; programs; radiologist; rectal; simulation; tool; tumor; virtual

Prostate cancer represents one of the most significant challenges in medicine and public health, facing the US healthcare system today. Its increased diagnosis has lead to a virtual "epidemic of this disease. MRI is uniquely suited to imaging the prostate as it allows excellent visualization of the gland, its boundary, substructure and all surrounding tissues. We have developed both a MR-guided prostate brachytherapy and biopsy program, which utilizes the open 0.5T interventional MRT system. We propose to adapt and translate these programs to meet the major advantages offered by high-field MRI (3T). In the proposed research we plan to apply an interactive comprehensive MR image- guided program for the diagnosis and treatment of localized prostate cancer. This integrated system will allow preoperative and intraoperative MR images of the prostate to be available on-line in the operating room. The challenge is to increase the information content of intraoperative image data by using multimodal features while at the same time preserving the interactivity and the near-real time features of intraoperative imaging, in a closed bore high-field system. But if this can be achieved the precise delivery of treatment to maximize tumor control, and minimize side effects will be achieved and will improve the patients quality of life after treatment.

前列腺癌代表了医学和公共卫生中最重要的挑战之一，面对 今天的美国医疗保健系统。它的诊断增加导致了“这种疾病流行的虚拟流行。MRI是 独特地适合成像前列腺，因为它可以很好地可视化腺体，边界， 下部结构和所有周围的组织。我们既开发了MR引导的前列腺近距离放射治疗，又有 活检计划，利用开放的0.5T介入MRT系统。 我们建议适应和翻译这些程序，以满足高场MRI提供的主要优势 （3T）。在拟议的研究中，我们计划采用交互式综合图像指导计划 用于诊断和治疗局部前列腺癌。该集成系统将允许术前 以及前列腺的术中MR图像，可在手术室内在线提供。 挑战是通过使用多模式来增加术中图像数据的信息内容 同时保留术中互动性和近实时间特征的功能 成像，在封闭的孔高场系统中。但是，如果可以实现这一点的精确处理 最大化肿瘤控制并最大程度地减少副作用，并将提高患者的质量 治疗后的生活。