SEARCH for Diabetes in Youth 2: Washington Site

搜索青少年糖尿病 2：华盛顿网站

• 批准号: 7678500
• 负责人: Catherine Pihoker
• 金额: $ 85.86万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7678500
• 关键词: SEARCH; Diabetes; Youth; Washington; Site

This proposal builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. The Washington site contributed a large, diverse study population to SEARCH1. With an extensive network in place including investigators and collaborators who have regular contact with new and continuing participants, the WA site can efficiently recruit and follow cases. A new collaboration with the WA Department of Health emphasizing diabetes surveillance and quality of care, and continued collaboration in SEARCH2 with local investigators with expertise in diabetes research and evolution of disease will provide a very positive research atmosphere and great productivity. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth.

该建议建立在一个五年的研究项目，在青年中寻找糖尿病，其标准化数据 收集工作，经验丰富的调查员团队，建立了案例确定基础架构以及种族 种群多样化。这是来自六个搜索临床站点的常见，集成的应用程序， 建议继续并扩展搜索执行的工作，以解决以下特定 研究目的：目标1：前瞻性确定新诊断（2006-2009）事件病例年龄小于 为了估计年轻人DM发病率的时间趋势；目标2：进行纵向 为了记录2002 - 2005年已招募的事件案件的后续行动，以记录 根据临床和生化因素新诊断为DM；目标3：在 搜索和扩大护理评估质量范围以更广泛地涵盖的前五年 定义的概念和质量衡量；目标4：开发和验证简单和低成本的案例定义 以及可用于公共卫生监视的年轻人中DM类型的分类。这个新奇 提案包括其全面的性质，汇集了儿童时期的主要和及时的方面 研究：一项在美国独特的流行病学研究，是关于DM发病率的时间趋势 青年;一种针对年轻人DM自然历史的病理生理组件；一项研究 照顾和生活质量；以及关于年轻人DM案例分类的公共卫生观点。这 华盛顿网站为搜索贡献了大量的研究人群。具有广泛的网络 包括定期与新的和持续联系的调查员和合作者在内的地点 参与者，西澳网站可以有效招募和遵循案件。与WA的新合作 卫生部强调糖尿病监测和护理质量，并继续合作 搜索2与本地研究人员具有糖尿病研究专业知识和疾病进化的专业知识将提供 非常积极的研究氛围和出色的生产力。这项研究对公众至关重要 健康将提供有关不同年轻人的DM是否增加的信息 美国的种族/族裔群体，关于DM对身体健康的影响，包括 并发症以及有关护理质量和这些青年生活质量的宝贵数据。

项目成果

Estimating incidence of type 1 and type 2 diabetes using prevalence data: the SEARCH for Diabetes in Youth study.

• DOI: 10.1186/s12874-023-01862-3
• 发表时间: 2023-02-14
• 期刊: BMC medical research methodology
• 影响因子: 4
• 作者: Hoyer A;Brinks R;Tönnies T;Saydah SH;D'Agostino RB Jr;Divers J;Isom S;Dabelea D;Lawrence JM;Mayer-Davis EJ;Pihoker C;Dolan L;Imperatore G
• 通讯作者: Imperatore G

Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study.

结合常规临床测量的临床预测模型在识别由维持内源性胰岛素分泌定义的青年发病 2 型糖尿病方面具有很高的准确性：青年研究中的糖尿病搜索。

• DOI: 10.2337/dc23-1815
• 发表时间: 2024
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Jones,AngusG;Shields,BeverleyM;Oram,RichardA;Dabelea,DanaM;Hagopian,WilliamA;Lustigova,Eva;Shah,AmyS;Knupp,Julieanne;Mottl,AmyK;D'Agostino,RalphB;Williams,Adrienne;Marcovina,SanticaM;Pihoker,Catherine;Divers,Jasmin;Red
• 通讯作者: Red