An fMRI Investigation of the Neural Pathways Behind Emotional Acceptance

情绪接受背后神经通路的功能磁共振成像研究

• 批准号: 7676945
• 负责人: Kristen K Ellard
• 金额: $ 3.25万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-08 至 2012-05-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7676945
• 关键词: Affect; Aftercare; American; Amygdaloid structure; Anterior; Anxiety; Anxiety Disorders; Clinical; Communication; Country; Development; Disease; Educational Intervention; Emotional; Emotional disorder; Emotions; Etiology; Fellowship; Foundations; Functional Magnetic Resonance Imaging; Future; Generalized Anxiety Disorder; Goals; Hippocampus (Brain); Hour; Image; Individual; Insula of Reil; Intervention; Investigation; Life; Menin; Mood Disorders; Moods; Neural Pathways; Neurosciences; Participant; Patient Self-Report; Patients; Pattern; Population; Prefrontal Cortex; Procedures; Process; Regulation; Relative (related person); Research; Route; Sampling; Structure; Techniques; Training; Treatment Protocols; Work; affective neuroscience; attenuation; base; career; cingulate cortex; cognitive behavior therapy; cost; disorder later incidence prevention; emotion regulation; emotional experience; emotional stimulus; experience; improved; interest; neuromechanism; psychosocial; public health relevance; relating to nervous system; research study; response; skills; skills training; successful intervention; tool

DESCRIPTION (provided by applicant): The specific goals of the research study proposed for this fellowship are to use functional magnetic resonance imaging (fMRI) to gain a better understanding of the neural mechanisms underlying emotional acceptance as an emotion regulation technique, while simultaneously providing invaluable training in the use of fMRI as a research tool. Through the use of fMRI, the proposed study will examine patterns of activation and de-activation in neural structures while engaging in emotional acceptance as an emotion regulation strategy in a clinical sample. Specifically, this study will examine the following: 1) activation of specific regions of interest (ROIs; amygdala, insula, hippocampus, anterior cingulate cortex, orbitofrontal cortex, prefrontal cortex) of an "Accept" condition relative to "Attend" and "Suppress" conditions during a negative emotion induction; 2) differences in patterns of activation in these two conditions between those who have and have not undergone skills training in emotional acceptance as an emotion regulation strategy; and 3) the relationship between changes in patterns of activation and self-reported changes in the subjective experience of negative emotion. Skills training in emotional acceptance skills will be based upon procedures currently used in the Unified Protocol for the Treatment of Emotional Disorders (Barlow, Allen, Ellard & Fairholme, 2008), and will be carried out over five, 1-hour sessions prior to a post-treatment imaging session. The broader aim of this study is to bridge affective neuroscience and emotion regulation research to investigate the neural mechanisms associated with emotional acceptance to gain a better understanding of the ultimate utility of this approach as applied to the treatment of anxiety and mood disorders. PUBLIC HEALTH RELEVANCE: Anxiety and mood disorders disrupt the lives of millions of Americans, with lifetime prevelance rates for anxiety disorders estimated at 29% of the population, and mood disorders at 21% (Kessler et al., 2005). Further, anxiety disorders alone represent a cost to this country of over $42 billion annually (Greenberg et al., 1999). It is hoped that by understanding how emotion regulation strategies such as emotional acceptance affect communication between cortical and limbic structures during emotional processing, we might gain a better understanding not only of the etiology of anxiety and mood disorders at a neural level, but also of how to effectively ameliorate or correct maladaptive emotional processing in these disorders using a unified, transdiagnostic approach. The experience of conducting this study will provide a strong foundation from which to pursue long-term career goals - to bridge affective neuroscience and emotion regulation research to improve psychosocial treatments for anxiety and mood disorders.

描述（由申请人提供）：该研究金提出的研究研究的具体目标是使用功能磁共振成像（fMRI）更好地了解情感接受作为情感调节技术的神经机制，同时在使用FMRI作为研究工具的使用中提供宝贵的培训。通过fMRI的使用，拟议的研究将检查神经结构中的激活和流动模式，同时将情感接受作为临床样本中的情绪调节策略。具体而言，这项研究将研究以下内容：1）激活特定的感兴趣区域（ROI；杏仁核，岛状，海马，海马，前扣带回皮层，眶额皮层，前额叶皮层，前额叶皮层），相对于“参加”和“抑制”在负面情绪诱导过程中的“接受”条件。 2）在这两个条件下激活模式的差异是那些接受和没有接受情感接受技能培训作为情感调节策略的技能培训的人； 3）激活模式的变化与负面情绪主观体验的自我报告变化之间的关系。情感接受技能的技能培训将基于目前在统一方案中用于治疗情绪障碍的程序（Barlow，Allen，Ellard＆Fairholme，2008年），并将在五次，1小时的时间内进行，然后进行五个小时的疗程。这项研究的更广泛的目的是桥接情感神经科学和情绪调节研究，以研究与情绪接受相关的神经机制，以更好地了解这种方法用于治疗焦虑和情绪障碍的最终实用性。公共卫生相关性：焦虑和情绪障碍破坏了数百万美国人的生活，焦虑症的终生良好率估计为人口的29％，情绪障碍为21％（Kessler等，2005）。此外，仅焦虑症代表了这个国家每年超过420亿美元的成本（Greenberg等，1999）。希望通过了解情感接受等情绪调节策略如何影响情绪处理过程中皮质和边界结构之间的沟通，我们不仅可以更好地理解神经层面上焦虑和情绪障碍的病因，而且还可以通过使用统一的跨性别的方法在这些疾病中有效地减轻或正确地适应不良的情绪处理。进行这项研究的经验将为追求长期职业目标提供坚实的基础 - 桥接情感神经科学和情感调节研究，以改善焦虑和情绪障碍的社会心理治疗。