Next generation Magnetoencephalography for human social neuroscience

用于人类社会神经科学的下一代脑磁图

• 批准号: 10224930
• 负责人: STEPHEN M LACONTE
• 金额: $ 58.22万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10224930
• 关键词: 3D Print; Address; Brain; Brain Diseases; Brain imaging; Clinical; Cognition; Cognition Disorders; Complex; Data; Data Analyses; Dependence; Detection; Development; Dissociation; Electroencephalography; Electromagnetic Fields; Engineering; Environment; Face; Frequencies; Functional Magnetic Resonance Imaging; Future; Generations; Helmet; Human; Image; Imaging technology; Industry; Institution; Interpersonal Relations; Lead; Location; Magnetic Resonance Imaging; Magnetism; Magnetoencephalography; Measurement; Measures; Mental disorders; Metals; Modeling; Motion; Motor; Movement; Near-Infrared Spectroscopy; Neurosciences; Noise; Optics; Performance; Persons; Physical environment; Physics; Planet Earth; Positioning Attribute; Positron-Emission Tomography; Pump; Research; Scalp structure; Signal Transduction; Site; Social Environment; Social Interaction; Source; Structure; System; Technology; Time; Validation; Virginia; Work; base; cost; design; experimental study; flexibility; improved; innovation; magnetic field; nervous system disorder; neuroimaging; next generation; quantum technologies; reconstruction; relating to nervous system; research and development; sensor; sensor technology; social; social cognition; social movement; social neuroscience; superconducting quantum interference device; temporal measurement; tool

PROJECT SUMMARY This proposal develops the next generation magnetoencephalography (MEG) for human social neuroscience by combining the latest available technology in optically-pumped magnetometers (OPMs) and magnetically shielded rooms (MSRs). Successful completion of the proposed research and development will enhance MEG's ease of use to enable the first ever 2-person face-to-face MEG recordings of social interactions. Motivated by a pressing need to improve the relevance of human neuroimaging - which includes upright, social movement - scalp-based sensors represent the most promising set of technologies that are both available now and are also expected to enjoy major improvements over the next several decades. While electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) are currently capable of such recordings, both suffer from limitations that would be complimented or ameliorated by “untethered” MEG. Within this context, the research objectives of this proposal are threefold. First, Aim 1 integrates the latest generation of OPM sensors and MSR technology to deliver a next generation platform for OPM-MEG experiments. These data, then provide a positive control to use this system for multi-person, movement tolerant neuroimaging in Aim 2. Finally, in Aim 3 we will evaluate sensor mounting strategies and source reconstructions strategies that will avoid obscuring parts of the face and could reduce cost and improve experimental ease. The work proposed will conducted by an assembled team of the world's leading academic and industry experts in OPM-MEG, magnetic shielding, social neuroimaging, and neuroimaging data analysis.

项目概要 该提案通过以下方式开发了用于人类社会神经科学的下一代脑磁图（MEG）： 结合了光泵磁力计 (OPM) 和磁力计中最新的可用技术 屏蔽室（MSR）的成功完成拟议的研究和开发将增强 MEG 的能力。 易于使用，首次实现 2 人面对面的 MEG 社交互动记录。 迫切需要提高人类神经影像的相关性（包括直立、社会运动） 基于头皮的传感器代表了最有前途的技术，这些技术既可以使用，也可以使用 预计在未来几十年内将获得重大改进。 和功能近红外光谱（fNIRS）目前能够进行此类记录，但两者都受到 在此背景下，“不受束缚”的 MEG 可以弥补或改善这些局限性。 该提案有三个目标：首先，Aim 1 集成了最新一代的 OPM 传感器和 MSR。 技术为 OPM-MEG 实验提供了下一代平台，然后为这些数据提供了积极的支持。 在目标 2 中控制使用该系统进行多人、运动耐受的神经成像。最后，在目标 3 中，我们将 评估传感器安装策略和源重建策略，以避免遮挡部分 面，可以降低成本并提高实验的便利性，拟议的工作将由组装进行。 由OPM-MEG、磁屏蔽、社会学领域世界领先的学术和行业专家组成的团队 神经影像和神经影像数据分析。