Imaging

影像学

基本信息

批准号：
10220888
负责人：
CHRISTOPHER T WHITLOW
金额：
$ 18.47万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-17 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10220888
关键词：
Animals Biodistribution Brain Neoplasms Catheters Cessation of life Collaborations Contrast Media Convection Cyclotrons Diagnosis Discipline of Nuclear Medicine Doctor of Philosophy Drug Delivery Systems Ensure Equipment Evaluation Glioblastoma Goals Growth Image Laboratories Leadership Lesion Magnetic Resonance Imaging Malignant - descriptor Malignant Glioma Malignant neoplasm of brain Medical Methods Modeling Multimodal Imaging Patients Pharmaceutical Preparations Physicians Play Positron-Emission Tomography Pre-Clinical Model Radiochemistry Recording of previous events Research Research Personnel Resource Sharing Resources Role Route Services Strategic Planning Structure Techniques Technology Therapeutic Therapeutic Uses Time United States Visualization Work clinically relevant drug distribution experience forest imaging modality in vivo innovation microPET/CT molecular imaging neuro-oncology new therapeutic target non-invasive imaging novel novel therapeutics pre-clinical radiotracer response targeted treatment tumor

项目摘要

Advanced imaging plays a vital role in neuro-oncology research. The goal of this Imaging Core, Core 4, is to provide expertise and access to advanced imaging equipment required by the various projects of this P01 proposal. The objective of the Core is to organize the needs of Projects 1-4 and match them with the requisite know-how and advanced technology. We will accomplish our objectives in three specific aims: Specific Aim 1: To utilize non-invasive imaging to diagnose GBM, evaluate longitudinal progression, and response to therapy. Specific Aim 2: To directly radiolabel our novel targeted therapeutics and evaluate long-term biodistribution and tumor targeting. Specific Aim 3: To image loco-regional therapy administration to ensure proper placement of our advanced delivery vehicles and proper therapeutic distribution. Thus, Core 4 will provide indispensable services to all Projects in this PPG application. It will comply with one of the most important requirements in developing efficient drug delivery means by offering direct visualization of malignant lesions, access of drugs to these lesions and changes in their response to therapy. Core 4 integration with all the projects represents a considerable strength of our PPG application.

先进成像在神经肿瘤学研究中发挥着至关重要的作用。该成像核心（Core 4）的目标是提供本 P01 的各个项目所需的专业知识和先进成像设备的使用权提议。核心的目标是组织项目 1-4 的需求并将其与必要的条件相匹配专业知识和先进技术。我们将通过三个具体目标来实现我们的目标：具体目标 1：利用非侵入性成像来诊断 GBM、评估纵向进展以及对治疗的反应治疗。具体目标 2：直接放射性标记我们的新型靶向治疗药物并评估长期效果生物分布和肿瘤靶向。具体目标 3：对局部区域治疗给药进行成像确保我们先进的运载工具的正确放置和适当的治疗分配。因此， Core 4将为该PPG应用中的所有项目提供不可或缺的服务。它将符合其中一项通过提供直接可视化来开发有效的药物输送方式的最重要要求恶性病变、药物到达这些病变的途径以及它们对治疗反应的变化。核心4 与所有项目的集成代表了我们 PPG 应用程序的相当大的优势。