NEURAL SUBSTRATES AND COGNITIVE EFFECTS OF MARIJUANA

大麻的神经基质和认知效应

• 批准号: 2772531
• 负责人: CHRISTOPHER T WHITLOW
• 金额: $ 4.22万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2772531
• 关键词: autoradiography; cannabinoid receptor; clinical research; cognition; cognition disorders; drug administration rate /duration; functional magnetic resonance imaging; human subject; laboratory rat; marijuana abuse; neuropharmacology; neuropsychological tests; urinalysis

DESCRIPTION: (Applicant's Abstract) Marijuana is the most frequently used illicit substance in our society. The neurobiological mechanisms underlying the neuropsychological effects of are still poorly understood, and effective strategies to treat the approximately lOO,OOO individuals admitted to treatment every year for marijuana use are lacking. New evidence suggests that marijuana produces changes in the brain that are similar to those observed following chronic use of harder drugs, implicating marijuana as a possible gateway drug (Tanda et al., 1997 and Rodriguez de Fonseca et al., 1997). Additional research needs to be conducted to assess the impairment of cognitive/decision making abilities, as such impairments may be particularly salient to the potential for escalated drug use. Although several studies have addressed the cognitive effects of marijuana, the anatomical distribution and underlying mechanisms of these effects have received little attention. Therefore, the aims of the proposed study are to use neuroimaging methods: 2-[14C]deoxyglucose, CB1 receptor, and [35S]GTPyS autoradiography (in rodents), as well as functional magnetic resonance imaging (in humans), to (1) investigate the dose-dependent, time-dependent, and residual effects of acute and chronic marijuana on brain activity in the rat using treatment regimens that have previously been associated with cognitive impairment, and to (2) determine the neurobiological substrates directly related to impaired performance of cognitive tasks, demonstrated in humans who frequently use marijuana.

描述：（申请人摘要） 大麻是我们社会中最常用的非法物质。 这 神经心理学效应背后的神经生物学机制是 仍然知之甚少，并且有效的策略来治疗大约 每年有 100,000 名因吸食大麻而接受治疗的人 缺乏。 新证据表明大麻会对大脑产生变化 与长期使用更强效药物后观察到的情况类似， 暗示大麻可能是一种入门毒品（Tanda 等人，1997 年和 罗德里格斯·德丰塞卡等人，1997）。 需要进行额外的研究 进行评估认知/决策能力的损害， 因为这种损害可能对潜在的特别显着 药物使用升级。 尽管多项研究已经探讨了认知 大麻的影响、解剖分布和潜在机制 这些影响很少受到关注。 因此，该组织的目标 拟议的研究将使用神经影像学方法：2-[14C]脱氧葡萄糖，CB1 受体，和 [35S]GTPyS 放射自显影（啮齿类动物），以及功能性 磁共振成像（人体），以 (1) 研究 急性和慢性的剂量依赖性、时间依赖性和残留效应 使用具有以下治疗方案的大麻对大鼠大脑活动的影响 以前被认为与认知障碍有关，并且（2）确定 与性能受损直接相关的神经生物学底物 认知任务，在经常吸食大麻的人身上得到证实。