Oral Health in People with Systemic Sclerosis

系统性硬化症患者的口腔健康

• 批准号: 7460896
• 负责人: Hon K Yuen
• 金额: $ 21.66万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-02 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7460896
• 关键词: Adult; Affect; African American; Age; Behavior; Behavioral; Centers of Research Excellence; Characteristics; Clinical; Clinical Research; Connective Tissue Diseases; Cross-Sectional Studies; Data; Data Collection; Data Set; Databases; Dental; Dental Facilities; Dental Hygiene; Dental Insurance; Dental Staff; Dental caries; Disease; Disease regression; Dryness; Enrollment; Ensure; Epidemiologic Studies; Exhibits; Frequencies; Gender; General Population; Goals; Health Services; Health Status; High Prevalence; Impairment; Income; Intervention; Literature; Living Wills; Manuals; Measures; Medical; Microbe; Microstomia; Modeling; Morbidity - disease rate; Mouth Diseases; National Health and Nutrition Examination Survey; Oral; Oral Manifestations; Oral health; Patients; Periodontal Diseases; Pharmaceutical Preparations; Population; Public Health; Quality of life; Race; Research; Resources; Respondent; Risk; Risk Factors; Sampling; Scleroderma; Severities; Severity of illness; South Carolina; Subgroup; Systemic Scleroderma; Systemic disease; Time; Tobacco use; Tooth structure; Universities; Woman; Xerostomia; base; caucasian American; craniofacial; design; disease classification; experience; health disparity; health related quality of life; improved; innovation; microbial; multidisciplinary; size; therapy development

DESCRIPTION (provided by applicant): The broad, long-term objective of our proposed research is to understand the oral health status, oral health- related behaviors, and quality of life in the US population of patients with systemic sclerosis (scleroderma or SSc). SSc is a rare, progressive connective tissue disease that affects predominately women (3.8:1) with a higher risk of the severe form among African-Americans. SSc adults experience manifestations of the systemic disease that include microstomia, xerostomia, and impaired manual dexterity. The two specific aims of this study are: 1) to characterize the oral health status of adults with SSc, and 2) to determine the SSc disease specific manifestations (microstomia, xerostomia, and manual dexterity impairments) that are associated with the severity of oral health problems and oral health-related quality of life among adults with SSc. This first study of US adults with SSc is a cross-sectional survey of 250 adults with SSc in South Carolina. This population is 25% African-American which is similar to the racial distribution of SSc in the US adult population. Data collection includes information on: oral health status (periodontal, dental, mucosal and microbial), oral manifestations of SSc (size of oral aperture, severity of oral dryness, and manual dexterity for oral hygiene), and oral health-related behaviors and quality of life. The oral health status of the South Carolina SSc population will be compared to that of the adult US population based on an analysis of corresponding measures using the National Health and Nutrition Examination Survey 1999-2002 data. Multivariable regression modeling will be used to evaluate hypothesized risk and protective factors that are associated with oral health status in adults with SSc. Results of this study in South Carolina will be used in regional efforts for the development of interventions for improved oral health status of adults with SSc. Second, these results will provide the basis for a larger US study of oral health problems of adults with SSc. The public health impact of this study will be the application of the greater understanding of the oral health status, oral health related behaviors, and quality of life of patients with systemic sclerosis (scleroderma or SSc). It is hoped that risks and protective factors can be identified to be associated with the oral health status of adults with systemic sclerosis, leading to the development of interventions for improved oral health in this population, and providing the basis for a larger study of oral health problems of adults with systemic sclerosis.

描述（由申请人提供）：我们提出的研究的广泛、长期目标是了解美国系统性硬化症（硬皮病或 SSc）患者的口腔健康状况、口腔健康相关行为和生活质量。 SSc 是一种罕见的进行性结缔组织病，主要影响女性 (3.8:1)，非洲裔美国人患严重疾病的风险较高。 SSc 成人会出现全身性疾病的表现，包括小口、口干和手灵活性受损。本研究的两个具体目的是：1) 描述成人 SSc 的口腔健康状况特征，2) 确定与口腔严重程度相关的 SSc 疾病具体表现（口小、口干和手灵巧性障碍）。患有 SSc 的成年人的健康问题和口腔健康相关的生活质量。这是针对美国 SSc 成年人的第一项研究，是对南卡罗来纳州 250 名 SSc 成年人进行的横断面调查。该人群中有 25% 是非裔美国人，这与美国成年人口中 SSc 的种族分布相似。数据收集包括以下信息：口腔健康状况（牙周、牙齿、粘膜和微生物）、SSc 口腔表现（口腔孔径大小、口腔干燥严重程度和口腔卫生手动灵活性）以及口腔健康相关行为和质量的生活。将根据使用 1999-2002 年国家健康和营养检查调查数据对相应措施进行分析，将南卡罗来纳州 SSc 人口的口腔健康状况与美国成年人口的口腔健康状况进行比较。多变量回归模型将用于评估与 SSc 成人口腔健康状况相关的假设风险和保护因素。南卡罗来纳州的这项研究结果将用于该地区制定干预措施以改善 SSc 成人口腔健康状况的努力。其次，这些结果将为美国针对 SSc 成人口腔健康问题进行更大规模的研究提供基础。这项研究对公众健康的影响将在于更好地了解系统性硬化症（硬皮病或 SSc）患者的口腔健康状况、口腔健康相关行为和生活质量。希望能够确定与系统性硬化症成人口腔健康状况相关的风险和保护因素，从而制定改善该人群口腔健康的干预措施，并为更大规模的口腔健康研究提供基础患有系统性硬化症的成年人的问题。