10 Biostatistics Resource Group

10 生物统计资源组

基本信息

批准号：
10212258
负责人：
J. Jack LEE
金额：
$ 97.05万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-08-28 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10212258
关键词：
Adopted Basic Science Bayesian Method Behavioral Biometry Cancer Center Cancer Center Support Grant Clinic Clinical Clinical Research Clinical Research Protocols Clinical Trials Clinical Trials Data Monitoring Committees Clinical Trials Design Collaborations Collection Complex Computer software Conduct Clinical Trials Consensus Consult Consultations Continuing Education Data Data Analyses Data Set Degree program Development Doctor&apos s Degree Drops Early Diagnosis Educational Curriculum Educational process of instructing Educational workshop Ensure Exposure to Faculty Fostering Funding Futility Future Goals Grant Health Services Research IACUC Information Technology Institution Institutional Review Boards Joints Knowledge Laboratories Laboratory Animals Lead Malignant Neoplasms Mentors Methods Mission Modeling Monitor Moon Paper Patient Care Patient Recruitments Peer Review Phase Postdoctoral Fellow Prevention Procedures Protocols documentation Randomized Reproducibility Research Research Methodology Research Personnel Research Training Resources Rice Sample Size Schedule Schools Science Scientist Services Statistical Methods Structure Support Groups Technology Texas Time Toxic effect Training Training Programs Training and Education Translational Research United States National Institutes of Health Universities analytical method anticancer research base behavioral health cancer prevention cost database design design faculty mentor graduate student improved innovation lectures member method development next generation novel outreach patient safety precision oncology programs psychosocial skills statistics training opportunity web app web services

项目摘要

PROJECT SUMMARY: BIOSTATISTICS RESOURCE GROUP (BRG) The mission of the Biostatistics Resource Group (BRG) is to enhance the scientific excellence of research at MD Anderson through outstanding statistical designs and methods, including the proper and efficient use of standard and cutting-edge methods and the development of novel methods; and to train and mentor future biostatisticians through an innovative, relevant curriculum and through exposure to unique data sets, the latest research methodology and findings, and state-of-the-art computing technology. BRG faculty mentor postdoctoral fellows and participate in 3 formal doctoral degree programs, teaching courses and advising graduate researchers: (i) Quantitative Sciences at MD Anderson-UTHealth Graduate School of Biomedical Sciences; (ii) Interinstitutional Graduate Program in Biostatistics for Cancer Research, a joint effort with the Department of Statistics at Rice University; and (iii) a joint effort with Texas A&M University. Director Dr. J. Jack Lee and co-directors Dr. Yu Shen and Ms. Marcella Johnson lead the BRG, which contributes to rigor and reproducibility at the institution by holding weekly consensus reviews of all clinical and research protocols submitted for scientific review (except those with prior NIH approval and those submitted directly to the institutional review board [IRB]), collaborating in the design of all clinical trials initiated at MD Anderson, conducting the data analyses, and following operating procedures that facilitate reproducibility. The status of the BRG within an independent, quantitative science group ensures the objective assessment of research. A faculty member and statistical analyst team are assigned as the primary contacts for each research and clinical department within the institution, which fosters close collaboration and subject matter expertise within the assigned teams. Protocols and trials are evaluated before they are reviewed by the IRB to protect the scientific integrity of MD Anderson and the quality of patient care and laboratory animal use. All BRG faculty members and statistical analysts are available to collaborate or consult with clinical and laboratory-based researchers. The BRG provides added value through (i) Bayesian approaches to inference, adaptive randomization in clinical trials, and statistical and graphical modeling; (ii) Clinical Trial Conduct, a centralized collection of BRG-designed databases, web applications, and web services that support the conduct of clinical trials; and (iii) software programs to support clinical trial management, which are documented and distributed online to researchers around the world at no cost. During the past 6 years, the BRG supported 1,097 center members representing all CCSG programs and contributed to more than 1500 papers, 577 (38%) with IF >5 and 175 (11%) with IF >10. In grant Yr42, BRG utilization increased 20% compared with the previous 5-year average, and peer review-funded usage accounted for 77%. In Yr43, the institution contributed 44% ($3,337,751) of the total BRG operating expenses; other grant allocations covered 48% ($3,697,124), and CCSG funds provided 8% ($611,160). For Yr44, the BRG requests $629,456 (a 3% increase, but 7% of the total BRG operating expenses) from the CCSG.

项目摘要：生物统计资源组 (BRG) 生物统计资源组 (BRG) 的使命是提高医学博士研究的科学卓越性安德森通过出色的统计设计和方法，包括正确有效地使用标准前沿方法和新方法的开发；并培训和指导未来的生物统计学家通过创新的、相关的课程以及通过接触独特的数据集、最新的研究方法论和研究结果，以及最先进的计算技术。 BRG教师导师博士后研究员并参与 3 个正式博士学位课程、教学课程并为研究生研究人员提供建议：(i) MD 安德森-UTHealth 生物医学科学研究生院定量科学； (二) 机构间癌症研究生物统计学研究生项目，与莱斯大学统计系合作大学; (iii) 与德克萨斯农工大学共同努力。董事 J. Jack Lee 博士和联席董事 Yu 博士 Shen 和 Marcella Johnson 女士领导 BRG，这有助于提高该机构的严谨性和可重复性每周对提交科学审查的所有临床和研究方案进行共识审查（除了那些事先获得 NIH 批准的以及那些直接提交给机构审查委员会 [IRB] 的），合作参与 MD 安德森发起的所有临床试验的设计、数据分析以及后续操作促进再现性的程序。 BRG 在独立定量科学团体中的地位确保研究的客观评估。教员和统计分析师团队被分配为机构内每个研究和临床部门的主要联系人，这促进了密切的联系指定团队内的协作和主题专业知识。方案和试验之前经过评估它们由 IRB 进行审查，以保护 MD 安德森的科学完整性以及患者护理和治疗的质量实验动物的使用。所有 BRG 教职员工和统计分析师都可以合作或咨询与临床和实验室研究人员合作。 BRG 通过 (i) 贝叶斯方法提供附加值推理、临床试验中的自适应随机化以及统计和图形建模； (二) 临床试验 Conduct，BRG 设计的数据库、Web 应用程序和 Web 服务的集中集合，支持进行临床试验； (iii) 支持临床试验管理的软件程序，包括记录下来并免费在线分发给世界各地的研究人员。在过去的6年里，BRG 支持代表所有 CCSG 项目的 1,097 名中心成员，并撰写了 1500 多篇论文， 577 (38%) IF > 5 和 175 (11%) IF > 10。在第 42 年拨款中，BRG 利用率比去年增加了 20% 与前 5 年平均水平相比，同行评审资助的使用量占 77%。 43年，该机构占 BRG 运营支出总额的 44%（3,337,751 美元）；其他赠款分配覆盖 48% （3,697,124 美元），CCSG 基金提供 8%（611,160 美元）。对于第 44 年，BRG 要求 629,456 美元（增加 3%，但 BRG 总运营费用的 7%）来自 CCSG。